Assuntos
Neoplasias Encefálicas/patologia , Epilepsia do Lobo Temporal/patologia , Lobo Temporal/patologia , Teratoma/patologia , Neoplasias Encefálicas/complicações , Neoplasias Encefálicas/cirurgia , Epilepsia do Lobo Temporal/etiologia , Epilepsia do Lobo Temporal/cirurgia , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Convulsões/etiologia , Convulsões/patologia , Convulsões/cirurgia , Lobo Temporal/cirurgia , Teratoma/complicações , Teratoma/cirurgia , Tomografia Computadorizada por Raios X , Resultado do TratamentoAssuntos
Carcinoma/patologia , Neoplasias do Plexo Corióideo/patologia , Protocolos de Quimioterapia Combinada Antineoplásica , Carcinoma/fisiopatologia , Carcinoma/terapia , Neoplasias do Plexo Corióideo/fisiopatologia , Neoplasias do Plexo Corióideo/terapia , Cisplatino/uso terapêutico , Terapia Combinada , Ciclofosfamida/uso terapêutico , Etoposídeo/uso terapêutico , Humanos , Imuno-Histoquímica , Lactente , Masculino , Procedimentos Neurocirúrgicos , Vincristina/uso terapêuticoAssuntos
Tumor Rabdoide/patologia , Neoplasias da Medula Espinal/patologia , Teratoma/patologia , Antibióticos Antineoplásicos/administração & dosagem , Antineoplásicos Fitogênicos/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Pré-Escolar , Cisplatino/uso terapêutico , Ciclofosfamida/administração & dosagem , Doxorrubicina/administração & dosagem , Incontinência Fecal/etiologia , Humanos , Injeções Espinhais , Masculino , Tumor Rabdoide/cirurgia , Tumor Rabdoide/terapia , Neoplasias da Medula Espinal/cirurgia , Neoplasias da Medula Espinal/terapia , Teratoma/cirurgia , Teratoma/terapia , Vincristina/administração & dosagemAssuntos
Condrossarcoma/patologia , Condrossarcoma/cirurgia , Neoplasias da Base do Crânio/patologia , Neoplasias da Base do Crânio/cirurgia , Adolescente , Condrossarcoma/radioterapia , Cefaleia/etiologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Nistagmo Patológico/etiologia , Neoplasias da Base do Crânio/radioterapiaAssuntos
Neoplasias Encefálicas/diagnóstico , Cefaleia/etiologia , Hidrocefalia/etiologia , Teratoma/diagnóstico , Neoplasias Encefálicas/complicações , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/cirurgia , Pré-Escolar , Humanos , Masculino , Teratoma/complicações , Teratoma/patologia , Teratoma/cirurgia , Resultado do Tratamento , Vômito/etiologiaAssuntos
Ganglioneuroma/diagnóstico , Imageamento por Ressonância Magnética , Neoplasias da Medula Espinal/diagnóstico , Adolescente , Ganglioneuroma/complicações , Ganglioneuroma/diagnóstico por imagem , Ganglioneuroma/patologia , Humanos , Masculino , Radiografia , Escoliose/complicações , Escoliose/diagnóstico por imagem , Neoplasias da Medula Espinal/complicações , Neoplasias da Medula Espinal/diagnóstico por imagem , Neoplasias da Medula Espinal/patologiaRESUMO
OBJECTIVE: To describe the clinical features that distinguish accidental from abusive head injury in hospitalized children <24 months of age. METHODS: Prospective study of children <24 months of age hospitalized for head injury between August 1, 2000, and October 31, 2002. During hospitalization, children had computed tomographic scans of the brain, serial neurologic examinations, dilated ophthalmoscopic eye examinations, evaluation by a social worker, and, in some cases, a child abuse specialist. OUTCOME MEASURES: The main outcome measure was the proportion of children in each group with retinal hemorrhages (RHs). Secondary outcome measures were the proportion of children in each group who had vitreous hemorrhage; abnormal mental status on presentation; seizures; scalp hematomas; need for anticonvulsants; and operative procedures such as subdural tap, craniotomy, ventriculostomy, tracheostomy, and gastrostomy. RESULTS: Eighty-seven children were prospectively enrolled. Fifteen children were classified as having abusive head injury, and 72 were classified as having accidental head injury. Five children, all in the accidental head injury group, were excluded from statistical analysis, because they did not have a dilated ophthalmoscopic examination during their hospitalization. Thus 82 children were included in the statistical analysis. There were no significant differences between the 2 groups with respect to mean age, gender, or ethnicity. RHs were more likely to be seen in children with abusive head injury (60% vs 10%) and were more likely to be bilateral (40% vs 1.5%). Pre-RHs were more likely to be seen in children with abusive head injury (30% vs 0%). Premacular RHs and RHs that extended to the periphery of the retina were also more likely to be seen in children with abusive head injury (20% vs 0% and 27% vs 0%, respectively). Of the 7 children with accidental head injury who had RHs, 6 had unilateral RHs. Children with abusive head injury were more likely to have seizures (53% vs 6%) and an abnormal mental status on initial presentation (53% vs 1%). Children with accidental head injury were more likely to have scalp hematomas (6.7% vs 49%). CONCLUSIONS: RHs are seen more often in abusive head injury and often are bilateral and involve the preretinal layer. Children with abusive head injury were more likely to have RHs that cover the macula and extend to the periphery of the retina. Unilateral RHs can be seen in children with accidental head injury. Children with abusive head injury were more likely to present with abnormal mental status and seizures, whereas children with accidental head injury were more likely to have scalp hematomas. Such characteristics may be useful to distinguish accidental from abusive head trauma in children <24 months of age.
Assuntos
Acidentes , Maus-Tratos Infantis/diagnóstico , Traumatismos Craniocerebrais/etiologia , Hemorragia Retiniana/etiologia , Lesões Encefálicas/diagnóstico por imagem , Lesões Encefálicas/etiologia , Diagnóstico Diferencial , Feminino , Humanos , Lactente , Masculino , Estudos Prospectivos , Radiografia , Convulsões/etiologia , Fraturas Cranianas , Hemorragia SubaracnóideaRESUMO
Fetal stroke, or that which occurs between 14 weeks of gestation and the onset of labor resulting in delivery, has been associated with postnatal epilepsy, mental retardation, and cerebral palsy. The entity is caused by antenatal ischemic, thrombotic, or hemorrhagic injury. We present seven new cases of fetal stroke diagnosed in utero and review the 47 cases reported in the literature. Although risk factors could not be assigned to 50% of the fetuses with stroke, the most common maternal conditions associated with fetal stroke were alloimmune thrombocytopenia and trauma. Magnetic resonance imaging was optimal for identifying fetal stroke, and prenatal imaging revealed hemorrhagic lesions in over 90% of studies; porencephalies were identified in just 13%. Seventy-eight percent of cases with reported outcome resulted in either death or adverse neurodevelopmental outcome at ages 3 months to 6 years. Fetal stroke appears to have different risk factors, clinical characteristics, and outcomes than other perinatal or childhood stroke syndromes. A better understanding of those risk factors predisposing a fetus to cerebral infarction may provide a basis for future therapeutic intervention trials. Ozduman K, Pober BR, Barnes P, Copel JA, Ogle EA, Duncan CC, Ment LR. Fetal stroke.