1.
Org Lett
; 20(23): 7371-7374, 2018 12 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30418782
RESUMO
Chemo- and site-selective hydrosilylation of α- or ß-hydroxy amides using organocatalyst B(C6F5)3 and commercially available hydrosilanes is described. This transformation is operative under mild conditions and tolerates a wide range of functional groups. The reaction was applied for selective reduction of a specific amide group of the therapeutically important cyclic peptide cyclosporin A, demonstrating the potential usefulness of this catalytic method in late-stage structural transformations of drug lead molecules.