[Arterial Hypertension and Methylenetetrahydrofolate Reductase C677T Gene Polymorphism].

OBJECTIVE: to determine the association of polymorphisms of C677T methylenetetrahydrofolate reductase (MTHFR) gene with essential arterial hypertension (EH) in the group of patients of Belarusian ethnicity. METHODS: The clinical examination and molecular genetic study of the polymorphism C677T of MTHFR gene by polymerase chain reaction and restriction fragment length polymorphism analysis were performed in 423 people, including 315 patients with EH and 108 healthy individuals. RESULTS: The distribution of C and T alleles of polymorphism C677T of the MTHFR gene in hypertensive patients was 67.8 and 32.2%, in normotensive individuals - 71.8 and 28.2%, respectively. In the group of hypertensive patients, the prevalence of the TT (C677T) genotype of the MTHFR gene was 10.8%, in the healthy group - 5.5%. The TT genotype of the C677T MTHFR gene was more common in hypertensive patients with obesity in comparison with hypertensive patients with body mass index < 29.9 kg/m2 (61.8 vs 38.2%, respectively; p.

[Chromosome aberrations in different tissues of the murine rodents and amphibians from radionuclide-contaminated regions of Belarus]. / Khromosomnye aberratsii v razlichnykh tkaniakh myshevidnykh gryzunov i amfibii iz zagriaznennykh radionuklidami raionov Belarusi.

Cytogenetic investigations of amphibian and rodent populations from the contaminated by radionuclides regions of Belarus was conducted. A significant increase in the levels of cytogenetic anomalies in bone marrow cells and intestinal epithelium of amphibians and rodents, the levels of alveolar macrophages of rodents, and micronuclei in peripheral blood erythrocytes of amphibians was revealed. Presence of chromosome type aberrations indicates that radiation as a mutagenic factor was involved. No strict relationship between the levels of contamination of the area and levels of cytogenetic anomalies was found.