Drug adsorption studies on pregelatinized gladiolus starch.

A comparative evaluation of the adsorption properties of pregelatinized gladiolus starch and activated charcoal on such drugs as chloroquine phosphate, aspirin, ampicillin and caffeine has been made. Results indicate that the adsorption capacity increases with increase in concentration of adsorbent used. Pregelatinized gladiolus starch exhibited a higher complexation affinity for chloroquine phosphate than activated charcoal, while the reverse was observed in the case of aspirin. The adsorption of caffeine and ampicillin was insignificant with the adsorbents. The desorption profile was slower for the pregelatinized gladiolus starch than for activated charcoal. This slow release property might be exploited in formulations where sustained-release is the desired goal.

Antimicrobial properties of Thonningia sanguinea root extracts.

The aqueous and methanolic extracts of Thonningia sanguinea root, as well as seven fractions obtained by PTLC from the methanol extract, have been shown to possess varying degrees of antimicrobial activity.

A preliminary study on the anti-inflammatory properties of Emilia sonchifolia leaf extracts.

The aqueous and methanolic extracts of Emilia sonchifolia leaves progressively reduced rat paw oedema induced by subplantar injection of albumin, the aqueous extract showing a more pronounced effect than the methanol extract.

12-Hydroxy-ll-methoxy-diaboline: A New Alkaloid from Strychnos spinosa.

From the stem bark of STRYCHNOS SPINOSA two tertiary alkaloids were isolated. By means of their spectral data they were identified as 11-methoxy-diaboline and 12-hy-droxy-11-methoxy-diaboline.

The African Strychnos species and their alkaloids: a review.

A review of the phytochemistry of African Strychnos species and the biological activities of some species as well as of some individual alkaloids isolated from them is presented. Although pharmacological studies of 48 species showed that muscle-relaxant and/or convulsant properties were generally present, antimicrobial, cytotoxic and hypotensive properties among others have also been demonstrated by some of the species and/or alkaloids.

1HNMR Chemical Shift Values for Aromatic Protons in 2,3,9,10- and 2,3,10,11-tetrasubstituted Tetrahydroprotoberberine Alkaloids.

The (1)HNMR (CDCl (3)) data on 28 tetrahydroprotoberberine alkaloids have shown that it is possible, from the chemical shift values observed for the aromatic protons, not only to determine the substitution pattern but also the type of substituents carried on the two sites in rings A and D within this class of alkaloids.

Tertiary Phenolic Alkaloids from Chasmanthera dependens.

A phytochemical investigation of the tertiary phenolic alkaloidal fraction of the stems of CHASMANTHERA DEPENDENS H OCHST. (Menispermaceae) has yielded the tetrahydroprotoberberine type alkaloids govanine ( identical with(-)-tetrahydropseudocolumbamine) [1] and coreximine [2]; the pavine type alkaloid bisnorargemonine [3] and the morphinandienone type alkaloid pallidine [4].

Cycleanine N-oxide, a new alkaloid from Synclisia scabrida.

A phytochemical investigation of the stems of Synclisia scabrida Miers (Menispermaceae) resulted in the isolation of a number of known bisbenzylisoquinoline alkaloids: cycleanine, norcycleanine, cocsuline and cocsoline. A new alkaloid, cycleanine N-oxide was also isolated.

Alkaloids from Chasmanthera dependens.

A phytochemical investigation of the stem of Chasmanthera dependens Hochst led to the isolation and identification of five quaternary alkaloids: jatrorrhizine, columbamine, pseudocolumbamine, magnoflorine and palmatine and nine tertiary non-phenolic alkaloids: tetrahydropalmatine, liriodenine, lysicamine, oxoglaucine, glaucine, anonaine, nornuciferine, norglaucine and O,O-dimethylcorytuberine.