RESUMO
Fifty-six patients with refractory multiple myeloma were treated with intermittent courses of etoposide, doxorubicin, cyclophosphamide and high-dose betamethasone (EACB) every 4th week. The overall response rate was 30%. Durable remissions exceeding 1 year were obtained in 12 of the 17 responding patients. A significant prolongation of the survival time was found for responding patients (median 13 months) compared to those patients who did not respond (median 9 months) to EACB therapy (p = 0.01). A low frequency of neutropenic fever episodes was noted compared to other salvage treatment regimens. The EACB regimen was usually well tolerated and could be administered safely on an out-patient basis. This regimen might be an alternative especially for elderly patients unresponsive to initial therapy.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Mieloma Múltiplo/tratamento farmacológico , Análise Atuarial , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Protocolos de Quimioterapia Combinada Antineoplásica/toxicidade , Betametasona/administração & dosagem , Ciclofosfamida/administração & dosagem , Doxorrubicina/administração & dosagem , Esquema de Medicação , Resistência a Medicamentos , Etoposídeo/administração & dosagem , Seguimentos , Humanos , Pessoa de Meia-Idade , Mieloma Múltiplo/mortalidade , Mieloma Múltiplo/patologia , Estadiamento de Neoplasias , Recidiva , Terapia de Salvação , Análise de Sobrevida , Fatores de TempoRESUMO
Ciliary ganglia of 8 to 19 days in ovo and 1 to 10 days posthatched chickens have been investigated with the freeze-fracture technique. The satellite cell membrane contained at all ages specific small intramembrane particles about 6-7 nm in size and arranged in an orthogonal order (OAPs). Along with these specialized particles, gap junctions and tight junctional strands were found between adjacent satellite cells.
Assuntos
Gânglios/ultraestrutura , Animais , Membrana Celular/ultraestrutura , Embrião de Galinha , Galinhas , Técnica de Fratura por Congelamento , Microscopia EletrônicaRESUMO
Combined retrograde axonal tracing with the fluorescent dye Fast Blue and fluoride-resistant acid phosphatase (FRAP) histochemistry revealed that the FRAP-containing sensory neurons project to both somatic and autonomic peripheral nerves. Furthermore, the combination of indirect immunohistochemistry after colchicine treatment and FRAP histochemistry showed that a population of FRAP-containing sensory neurons are also substance P, cholecystokinin or somatostatin positive.
