RESUMO
This paper describes an original design leading to the field effect passivation of Si n+-p junctions. Ordered Ag nanoparticle (Ag-NP) arrays with optimal size and coverage fabricated by means of nanosphere lithography and thermal evaporation, were embedded in ultrathin-Al2O3/SiN x :H stacks on the top of implanted Si n+-p junctions, to achieve effective surface passivation. One way to characterize surface passivation is to use photocurrent, sensitive to recombination centers. We evidenced an improvement of photocurrent by a factor of 5 with the presence of Ag NPs. Finite-difference time-domain (FDTD) simulations combining with semi-quantitative calculations demonstrated that such gain was mainly due to the enhanced field effect passivation through the depleted region associated with the Ag-NPs/Si Schottky contacts.
RESUMO
To our knowledge, this communication is the first report of chemotaxis towards chlorophenols by any bacteria. We used a recently published method based on the agarose in-plug assay combined with video processing analysis and we also present a new index of bacterial mean speed for these assays.
Assuntos
Achromobacter/fisiologia , Quimiotaxia/fisiologia , Clorofenóis/farmacologia , Pseudomonas aeruginosa/fisiologiaAssuntos
Toxidermias/etiologia , Inibidores de Hidroximetilglutaril-CoA Redutases/efeitos adversos , Rosuvastatina Cálcica/efeitos adversos , Idoso , Betametasona/administração & dosagem , Betametasona/análogos & derivados , Biópsia , Toxidermias/diagnóstico , Toxidermias/tratamento farmacológico , Toxidermias/imunologia , Feminino , Glucocorticoides/administração & dosagem , Humanos , Testes do Emplastro , Valor Preditivo dos Testes , Fatores de Risco , Resultado do TratamentoAssuntos
Celulite (Flegmão)/imunologia , Culicidae/imunologia , Eosinofilia/imunologia , Mordeduras e Picadas de Insetos/imunologia , Interleucina-5/imunologia , Leucócitos Mononucleares/imunologia , Pele/imunologia , Administração Cutânea , Idoso de 80 Anos ou mais , Animais , Biópsia , Células Cultivadas , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/tratamento farmacológico , Celulite (Flegmão)/metabolismo , Eosinofilia/diagnóstico , Eosinofilia/tratamento farmacológico , Eosinofilia/metabolismo , Glucocorticoides/administração & dosagem , Humanos , Mordeduras e Picadas de Insetos/diagnóstico , Mordeduras e Picadas de Insetos/tratamento farmacológico , Mordeduras e Picadas de Insetos/metabolismo , Interleucina-5/metabolismo , Leucócitos Mononucleares/efeitos dos fármacos , Leucócitos Mononucleares/metabolismo , Masculino , Glândulas Salivares/imunologia , Pele/efeitos dos fármacos , Pele/metabolismo , Extratos de Tecidos/imunologia , Resultado do Tratamento , Regulação para CimaAssuntos
Antifúngicos/efeitos adversos , Dermatite Esfoliativa/induzido quimicamente , Toxidermias/etiologia , Interleucina-23/imunologia , Naftalenos/efeitos adversos , Psoríase/induzido quimicamente , Pele/efeitos dos fármacos , Idoso de 80 Anos ou mais , Betametasona/administração & dosagem , Betametasona/análogos & derivados , Biópsia , Células Cultivadas , Dermatite Esfoliativa/diagnóstico , Dermatite Esfoliativa/tratamento farmacológico , Dermatite Esfoliativa/imunologia , Toxidermias/diagnóstico , Toxidermias/tratamento farmacológico , Toxidermias/imunologia , Feminino , Glucocorticoides/administração & dosagem , Humanos , Ativação Linfocitária/efeitos dos fármacos , Metilprednisolona/administração & dosagem , Psoríase/diagnóstico , Psoríase/tratamento farmacológico , Psoríase/imunologia , Pele/imunologia , Pele/patologia , Linfócitos T Auxiliares-Indutores/efeitos dos fármacos , Linfócitos T Auxiliares-Indutores/imunologia , Terbinafina , Resultado do TratamentoRESUMO
No disponible
Assuntos
Humanos , Feminino , Idoso , Hipersensibilidade a Drogas/complicações , Hipersensibilidade a Drogas/diagnóstico , Rosuvastatina Cálcica/efeitos adversos , Exantema/induzido quimicamente , Betametasona/uso terapêutico , Exantema/complicações , Exantema/tratamento farmacológicoRESUMO
No disponible
Assuntos
Humanos , Masculino , Idoso de 80 Anos ou mais , Eosinofilia/complicações , Eosinofilia/imunologia , Interleucina-5/análise , Interleucina-5/imunologia , Celulite/complicações , Celulite/imunologia , Mordeduras e Picadas/imunologia , Insetos , Insetos/imunologia , Edema/complicações , Edema/imunologiaRESUMO
No disponible
Assuntos
Humanos , Masculino , Idoso , Síndrome de Stevens-Johnson/complicações , Síndrome de Stevens-Johnson/imunologia , Vacinas contra Influenza/efeitos adversos , Vacinas contra Influenza/imunologia , Hipersensibilidade a Drogas/complicações , Eritema/complicações , Mucosa Bucal , Mucosa Bucal/imunologiaRESUMO
No disponible
Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Hipersensibilidade a Drogas/complicações , Hipersensibilidade a Drogas/diagnóstico , Hipersensibilidade a Drogas/imunologia , Parapsoríase/induzido quimicamente , Parapsoríase/complicações , Parapsoríase/imunologia , Antifúngicos/efeitos adversos , Interleucina-23/administração & dosagem , Interleucina-23/análise , Ensaio de Imunoadsorção EnzimáticaRESUMO
We conducted a prospective follow-up MRI study of originally asymptomatic healthy subjects to clarify the development of Modic changes in the cervical spine over a ten-year period and to identify related factors. Previously, 497 asymptomatic healthy volunteers with no history of cervical trauma or surgery underwent MRI. Of these, 223 underwent a second MRI at a mean follow-up of 11.6 years (10 to 12.7). These 223 subjects comprised 133 men and 100 women with a mean age at second MRI of 50.5 years (23 to 83). Modic changes were classified as not present and types 1 to 3. Changes in Modic types over time and relationships between Modic changes and progression of degeneration of the disc or clinical symptoms were evaluated. A total of 31 subjects (13.9%) showed Modic changes at follow-up: type 1 in nine, type 2 in 18, type 3 in two, and types 1 and 2 in two. Modic changes at follow-up were significantly associated with numbness or pain in the arm, but not with neck pain or shoulder stiffness. Age (≥ 40 years), gender (male), and pre-existing disc degeneration were significantly associated with newly developed Modic changes. In the cervical spine over a ten-year period, type 2 Modic changes developed most frequently. Newly developed Modic changes were significantly associated with age, gender, and pre-existing disc degeneration.
Assuntos
Vértebras Cervicais/patologia , Doenças da Coluna Vertebral/diagnóstico , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Braço/inervação , Progressão da Doença , Feminino , Seguimentos , Humanos , Hipestesia/etiologia , Degeneração do Disco Intervertebral/complicações , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Cervicalgia/etiologia , Estudos Prospectivos , Fatores Sexuais , Articulação do Ombro/fisiopatologia , Doenças da Coluna Vertebral/etiologia , Doenças da Coluna Vertebral/fisiopatologia , Adulto JovemRESUMO
An adult female killer whale (Orcinus orca) was transported to the Port of Nagoya public aquarium in June 2010. While the animal was being maintained in the aquarium there was a gradual decrease in body weight. On October 1st, 2010 the whale exhibited signs of gastrointestinal disease and died on January 14th, 2011. At necropsy examination the gastric compartments were filled with a large number of variably-sized rocks (total weight 81.4 kg) and there was marked ulceration in the third compartment. There were multifocal tubercle-like nodules within the lungs and on sectioning there were numerous abscesses and pulmonary cavities. Microscopically, there was severe suppurative pneumonia associated with fungal hyphae that were infrequently septate and often branched. Numerous bacterial colonies were also present. The hyphae demonstrated immunohistochemical cross-reactivity with Rhizomucor spp. and Cunninghamella bertholletiae was cultured. Bacteriological culture revealed the presence of Proteus mirabilis, Pseudomonas aeruginosa and Pseudomonas oryzihabitans. This case represents the first documentation of zygomycosis associated with C. bertholletiae in a marine mammal.
Assuntos
Testes Hematológicos/veterinária , Pneumopatias Fúngicas/veterinária , Mucormicose/veterinária , Orca , Animais , Antifúngicos/uso terapêutico , Cunninghamella/isolamento & purificação , Feminino , Pneumopatias Fúngicas/tratamento farmacológico , Pneumopatias Fúngicas/patologia , Mucormicose/tratamento farmacológico , Mucormicose/patologiaRESUMO
The molecular mechanisms of vertebrate ZZ/ZW-type sex-determining systems remain unclear. We recently indicated that a W-linked gene, DM-W is a likely ovary-determining gene in Xenopus laevis. We first examined whether Cyp19 for estrogen-synthesizing enzyme P450 aromatase and Foxl2 showed female-specific expression in developing gonads. Both genes showed much higher expression in ZW than in ZZ gonads during and after sex determination. Importantly, transgenic ZZ gonads expressing exogenous DM-W at the sex-determining stage showed a ZW-type pattern of Cyp19 and Foxl2 expression. These results suggest that DM-W up-regulates Cyp19 and Foxl2 expression to guide primary ovary development in X. laevis.
Assuntos
Aromatase/genética , Fatores de Transcrição Forkhead/genética , Expressão Gênica , Processos de Determinação Sexual , Proteínas de Xenopus/genética , Xenopus/genética , Sequência de Aminoácidos , Animais , Animais Geneticamente Modificados , Aromatase/metabolismo , Sequência de Bases , Feminino , Proteína Forkhead Box L2 , Fatores de Transcrição Forkhead/metabolismo , Regulação da Expressão Gênica no Desenvolvimento , Dados de Sequência Molecular , Ovário/enzimologia , Ovário/metabolismo , Homologia de Sequência de Aminoácidos , Xenopus/metabolismo , Proteínas de Xenopus/metabolismoRESUMO
Pentachlorophenol (PCP) and its sodium salt (Na-PCP) are extremely toxic chemicals responsible for important soil and groundwater pollution, mainly caused by wastes from wood-treatment plants, because chlorinated phenols are widely used as wood preservatives. The methods most commonly used for routine analysis of pesticides such as PCP and Na-PCP are high-performance liquid chromatography (HPLC) and gas chromatography-mass spectroscopy (GC-MS). A variety of rapid biological screening tests using marine organisms, bioluminescent bacteria, and enzymes have also been reported. In this study, rapid biological screening analysis using Bacillus subtilis was developed, to assess the biodegradation of PCP and its by-products in liquid samples. An empirical model is proposed for spectrophotometric analysis of Na-PCP concentration after growth of Bacillus subtilis.
Assuntos
Bacillus subtilis/metabolismo , Bioensaio/métodos , Poluentes Ambientais/toxicidade , Pentaclorofenol/toxicidade , Bacillus subtilis/efeitos dos fármacos , Biodegradação Ambiental , Poluentes Ambientais/metabolismo , Pentaclorofenol/metabolismoRESUMO
PURPOSE: To ascertain and define the position of a potential disease susceptibility gene around D21S0083i prioritized during our previous whole genome case-control association analysis with 27,158 microsatellite markers, in Japanese high-myopia patients. METHODS: 520 high myopic patients and 520 healthy controls were genotyped using 39 SNPs distributed around D21S0083i on chromosome 21q22.3. RESULTS: Only 1 SNP (rs2839471) of 39 SNPs was significant after correction for multiple testing (allele T: P=0.00027, Pc=0.01, OR=1.684). The SNP (rs2839471) did not reside in haplotype blocks constructed by the pair-wise linkage disequilibrium between the SNPs. CONCLUSIONS: The SNP (rs2839471) is suggested to be located in the frequent recombinant region within UMODL1. Together this region might play a critical role for susceptibility to high myopia, and warrants further confirming studies and investigations as to the mechanisms by which UMODL1 may contribute to myopia.
Assuntos
Cromossomos Humanos Par 21/genética , Predisposição Genética para Doença/genética , Mucoproteínas/genética , Miopia/genética , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Genótipo , Humanos , Lactente , Masculino , Repetições de Microssatélites/genética , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único/genética , Uromodulina , Adulto JovemRESUMO
Double-balloon endoscopy (DBE) is a new technique that allows diagnosis and treatment throughout the entire small intestine. We have recently developed a method that allows a single operator to perform DBE, by employing "grip and pinch" and "hold (or 'keep') and slide" techniques. This one-person method obviates the need for two operators who must cooperate closely.
Assuntos
Endoscopia/métodos , Intestino Delgado/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Projetos PilotoRESUMO
An ulnar recurrent adipofascial flap was raised and turned over to reconstruct massive defects around the elbow and forearm after wide resection of malignant tumours. Compared to the fasciocutaneous flap, the ulnar recurrent adipofascial flap has the following advantages: (1) a larger flap can be harvested without the problem of primary closure of the donor site, (2) the contour and scar of the donor site is reasonably acceptable since no tension is presented, (3) the flap can be turned over to cover a wider area, and (4) debulking of the flap can be performed during the operation if needed. The rotation arc of the ulnar recurrent adipofascial flap reaches a wide region, including the distal one-half of the upper arm, the elbow, and the proximal two-thirds of the forearm. Sensory deficit in the forearm was avoided in our patients because meticulous separation and preservation of the medial cutaneous nerve of the forearm was achieved without jeopardising the blood supply to the flap. The ulnar recurrent adipofascial flap is an easy and reliable option for one-stage reconstruction of massive defects around the elbow.
Assuntos
Cotovelo/cirurgia , Antebraço/cirurgia , Histiocitoma Fibroso Benigno/cirurgia , Leiomioma/cirurgia , Neoplasias de Tecidos Moles/cirurgia , Retalhos Cirúrgicos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/cirurgia , ReoperaçãoRESUMO
The authors demonstrate successful cases of stepladder dorsal metacarpal V-Y advancement and rotation-advancement flaps for reconstructing defects on the dorsum of the finger and hand. One side of the flap is designed in a multilobed shape, and each lobed flap is designed on the dorsum of adjacent fingers. These flaps are supplied by dorsal metacarpal vessels. Consequently, this method has the elements of the stepped incision technique, in combination with the V-Y and rotation-advancement principle. All flaps survived completely. This technique may be a useful option for reconstruction of defects of the dorsum of the finger and hand.
