[Activity of the NO-system in lung after pulmonectomy of various volumes].

The study was designed to evaluate the activity of NO-system in lung after resection of various volumes. White male rats, subjected to left or right pulmonectomy, were used. Activity of the NO-system in lung was estimated as a difference in the contents of its metabolites (nitrates NO3(-) and nitrites NO2(-)), peroxynitrite (ONOO(-)), activity of endothelial (eNOS) and induced enzyme (iNOS), in arterial and venous blood for 3, 7, 14 day after pulmonectomy. It was revealed, that with the increase of a resections volume, activity of NO-system was reduced. Difference in parameters of NO-system activity in arterial and venous blood reflects endothelial dysfunctions in lung, and can be used as diagnostic criterion.

[Some pathogenic aspects of changes in non-respiratory function of the lungs in sepsis].

The study was carried out on 32 rabbits of diferrent sex. Sepsis model on these animals was developped. Changes of the cholesterol exchange in pulmonary pool at sepsis were tracked that allowed to confirm the phase of discrepancy in lung function. Obtained data may help in choosing the treatment tachtique in controlling sepsis.

[Surgical aspects of non-respiratory activity of the lungs during acute pyonecrotizing diseases]. / Khirurgicheskie aspekty nerespiratornoi deiatel'nosti legkikh pri ikh ostrykh gnoino-destruktivnykh zabolevaniiakh.

The preoperative preparation program based upon the experience of treating 465 patients with acute pyonecrotizing diseases of lungs was developed. This system takes into account the stage of the disease (I--septic, II--stabilization, III--remission), endotoxicosis intensity and non respiratory activity of the affected lung (NRAL). The patients of the first group (I stage of the disease) with long-term subclavian vein catheterization were on the special scheme of NRAL correction, their supurative focuses being treated with electrized hypochlorite sodium solution. The system appeared to be effective in managing patients, in the first group--254 patients of which 202 (79,9%) were successfully treated without operation, as for the second group, there were only 52 (40,6%), in the third--26 (31,3%). By limiting and stabilizing the process, the effect of this preoperative preparation program was also seen in other patients. It allowed to perform less traumatic operations (lung resection) in 109 patients of the 179 operated on, with 8,7% of postoperative complications in 8,7% in the first group vers. 18,4% and 24,6% in the second and third, respectively. Thus the above mentioned results show the proposed system to be effective.

[Modern principals of antibacterial therapy of suppurative-septic diseases]. / Sovremennye printsipy antibakterial'noi terapii gnoino-septicheskikh zabolevanii.

The carried out researches concerning initial nidus of infection have shown a high rate of anaerobic infection especially in patients with destructive-suppurative lung disease, liver abscess, peritonitis (up to 82.8%). An aerobic-anaerobic association of microbes remarkably often is found in the nidus of infection. We recommend the following preventive scheme to treat patients with different pyoseptic diseases. The scheme is based on the results of our 10 years experience treatment of such patients. It consists of a combination of 2.0 gr. cefoperazoli twice daily, metronidasoli 500 mg. 3 times and amycacini 500 mg twice daily. The intra-arterial or intravenous introduction of the medications was possibly preferred. Having analyzed the results of the treatment of 13,747 patients treated at the center of contaminated surgery, we would note that in 30.2% of the cases were reached excellent results. The above-mentioned scheme of antibacterial therapy with surgical correction of suppurative focus allowed us to reach good results in 45.4%. The satisfactory results of the treatment were achieved in 22.8% of patients. Mortality rate was up to 1.9%.