Validation and reference values of the EORTC QLQ-CML24 questionnaire to assess health-related quality of life in patients with chronic myeloid leukemia.

Health-related quality of life (HRQOL) assessment is important to facilitate decisions in the current treatment landscape of chronic myeloid leukemia (CML). Therefore, the availability of a validated HRQOL questionnaire, specifically developed for CML patients treated with tyrosine kinase inhibitors (TKIs), may enhance quality of research in this area. We performed an international study including 782 CML patients to assess the validity of the EORTC QLQ-CML 24 questionnaire, and to generate HRQOL reference values to facilitate interpretation of results in future studies. Internal consistency, assessed with Cronbach's alpha coefficients, ranged from 0.66 to 0.83. In the confirmatory factor analysis, all standardized factor loadings exceeded the threshold of 0.40 (range 0.49-0.97), confirming the hypothesized scale structure. Reference values stratified by age and sex were also generated. Our findings support the use of the EORTC QLQ-CML 24, in conjunction with the EORTC QLQ-C30, as a valuable measure to assess HRQOL in CML patients.

Psychosomatic illness in the analytical approach: an integrative literature review / Adoecimento psicossomático na abordagem analítica: uma revisão integrativa da literatura / Enfermedad psicosomática en el enfoque analítico: una revisión integradora de la literatura

It is known that studies about the dynamic mind-body aim at a better comprehension of the human being. According to the medical-scientific logic, some approaches dichotomize that interaction, relegating the term to cases of illnesses with no evident etiology. The psychosomatic approach proposes a holistic perspective on the individual, beyond the cure of physical symptoms. An integrative review on the comprehended psychosomatic was realized, in the paradigm of analytical psychology (AP). The search resulted in 44 articles that compounded theoretic-clinical discussion and/or empirical research about the object of study. Publications included philosophical and epistemological matters in psychosomatic, analysis of specific clinical cases, and possibilities of psychotherapeutic intervention. AP classic and developmental approaches are emphasized, and the main concepts found to comprehend the illness were psychic energy, teleology, synchronicity, and ego-self development. It was observed a higher concentration of articles with theoretical analysis illustrated with clinical vignettes and presentation of psychotherapeutic intervention proposals aiming to comprise the demands of the singular process in the dynamic between health and disease.

Estudos sobre a dinâmica mente-corpo visam à melhor compreensão sobre o ser humano. Há vertentes que dicotomizam tal interação, relegando o termo aos quadros de adoecimentos sem etiologia evidente conforme a lógica médico-científica. A abordagem psicossomática propõe perspectiva holística sobre o indivíduo, para além da cura do sintoma físico. Foi realizada uma revisão integrativa da psicossomática compreendida no paradigma da Psicologia Analítica (PA). A busca resultou em 44 artigos que compunham discussão teórico-clínica e/ou pesquisa empírica sobre o objeto de estudo. As publicações abrangiam questões filosóficas e epistemológicas em psicossomática, análise sobre casos clínicos específicos e possibilidades de intervenção psicoterapêutica. Ressaltam-se as vertentes clássica e desenvolvimentista da PA, e os principais conceitos encontrados para compreender o adoecimento foram energia psíquica, teleologia, sincronicidade e desenvolvimento do ego-Self. Observou-se maior concentração de artigos com análise teórica ilustrados com vinhetas clínicas e apresentação de propostas de intervenção psicoterapêutica visando compreender a demanda do processo singular na dinâmica entre saúde e doença.

Los estudios sobre la dinámica mente-cuerpo visan mejor comprensión sobre el ser humano. Hay vertientes que dicotomizan tal interacción, relegando el término a los casos de enfermedades sin etiología evidente conforme a la lógica médico-científica. El abordaje psicosomático propone perspectiva holística, además de la cura del síntoma físico. Se realizó una revisión integrativa de la psicosomática en el paradigma de la Psicología Analítica (PA). La búsqueda resultó en 44 artículos que componían discusión teórico-clínica y/o investigación empírica. Las publicaciones abarcaban cuestiones filosóficas y epistemológicas en psicosomática, análisis sobre casos clínicos específicos y posibilidades de intervención psicoterapéutica. Se resaltan las vertientes clásica y desarrollista de la PA, y los principales conceptos encontrados para comprender la enfermedad fueron energía psíquica, teleología, sincronicidad y ego-Self desarrollo. Se observó una mayor concentración de artículos con análisis teórico ilustrados con viñetas clínicas y presentación de propuestas de intervención psicoterapéutica destinadas a comprender las demandas del proceso singular en la dinámica entre salud y enfermedad.

Psychological well-being and social support in chronic myeloid leukemia patients receiving lifelong targeted therapies.

PURPOSE: The main objective of this study was to investigate whether social support is independently associated with psychological well-being in chronic myeloid leukemia (CML) patients. Secondary objectives were to compare the psychological well-being profile of CML patients with that of their peers in general population and to examine possible age- and sex-related differences. PATIENTS AND METHODS: Analysis was performed on 417 patients in treatment with lifelong molecularly targeted therapies. Mean age of patients analyzed was 56 years (range 19-87 years) and 247 (59 %) were male and 170 (41 %) were female. Social support was assessed with the Multidimensional Scale of Perceived Social Support and psychological well-being was evaluated with the short version of the Psychological General Well-Being Index. Descriptive statistics and multivariate logistic regression analyses were used. RESULTS: Multivariate logistic regression analysis revealed that a greater social support was independently associated with lower anxiety and depression, as well as with higher positive well-being, self-control, and vitality (p < 0.001). Female patients reported statistically significant worse outcomes in all dimensions of psychological well-being. Age- and sex-adjusted comparisons with population norms revealed that depression (ES = -0.42, p < 0.001) and self-control (ES = -0.48, p < 0.001) were the two main impaired psychological dimensions. CONCLUSION: This study indicates that social support is a critical factor associated with psychological well-being of CML patients treated with modern lifelong targeted therapies.