RESUMO
Valvular heart disease associated with the use of anorectic agents is a recently described clinical entity. We report the case of a 46-year-old woman with severe regurgitation of the mitral, aortic and tricuspid valves who had been taking fenfluramine and dexfenfluramine for two years. Surgical treatment was required with replacement of three valve by mechanical prostheses. The previous history of treatment with anorectic agents, the echocardiographic morphology of the injured valves and the macroscopic and histopathologic findings strongly suggested an association between the anorectic agents and the valvular disease of the patient.
Assuntos
Insuficiência da Valva Aórtica/induzido quimicamente , Depressores do Apetite/efeitos adversos , Fenfluramina/efeitos adversos , Implante de Prótese de Valva Cardíaca , Insuficiência da Valva Mitral/induzido quimicamente , Insuficiência da Valva Tricúspide/induzido quimicamente , Insuficiência da Valva Aórtica/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Insuficiência da Valva Mitral/cirurgia , Insuficiência da Valva Tricúspide/cirurgiaRESUMO
We review our experience in 38 patients with coarctation of the aorta during infancy. Cardiac failure was present in 30 patients, being the maximal incidence during the first and second weeks of the life. Sixteen infants died, 43% of them during the first week. Cardiac catherization and angiocardiography were performed in 22 infants. The coarctation of the aorta was isolated in 38 infants (36%). The most frequently associated malformations were: patent ductus arteriosus (6 cases), ventricular septal defect (5 cases) and the pathology of the left heart. The post mortem examination was performed in 11 infants; in all of them the CoAo was preductal with patent ductus arteriosus; the most frequently associated malformation was ventricular septal defect (6 cases). 5 infants were operated upon with succes during the first year of the life.
