[Use of the antioxidant complex of vitamins A, E and C in murine leukemia]. / Primenenie antioksidantnogo kompleksa vitaminov A, E i C pri leikoze myshei.

A study was made of the content of ubiquinone, vitamins A, E, ascorbic, dehydroascorbic and diketogulonic acids (DKGA), and malonic dialdehyde (MDA) in the liver, of the content of glutathione, the activity of superoxide dismutase (SOD) and glutathione reductase in red blood cells, of the content of vitamins A, E and ubiquinone in the spleen of C57Bl/6jG mice with inoculated leukemia La. It was found that in red blood cells of the animals with leukemia, the content of vitamin E and DKGA reduced, the MDA level increased, and the content of glutathione dropped whereas SOD activity rose. Application of the antioxidant complex of vitamins A, E, C appreciably improved the characteristics of enzymatic and non-enzymatic antioxidant protection of the liver and red blood cells of the leukemic animals without exerting any noticeable effect on the content of vitamin E and ubiquinone in the leukemic spleen tissue.

[Efficacy of the combined use of lipid- and water-soluble bioantioxidants (vitamins E, A and C)]. / Effektivnost' sovmestnogo primeneniia lipido- i vodorastvorimykh bioantioksidantov (vitaminov E, A i C).

Experiments on noninbred male rats were made to show appreciable differences in the effect of the isolated and combined use of vitamins E, A and C. This was manifested in the changes of tocopherol and ascorbic acid capacity of accumulation and utilization by the liver, of dissimilar effects on the contend of lipid peroxidation products and respiratory function of the mitochondria.

[Activity of membrane-bound enzymes, indices of metabolism in the cytoplasm and various physico-chemical properties of erythrocytes with increased cholesterol level]. / Aktivnost' membranno-sviazannykh fermentov, pokazateli metabolizma v tsitoplazme i nekotorye fiziko-khimicheskie svoistva éritrotsitov s povyshennym soderzhaniem kholesterina.

Activity of membrane-bound enzymes, passive penetration of ions in dose-dependent loading with cholesterol, effect of cholesterol high concentrations on the metabolic patterns in cytosol, viscosity of cell suspension were studied in erythrocytes. Passive cotransport of H+ and Cl- ions via erythrocyte membrane was increased with augmentation in viscosity of the cell suspension. After loading with cholesterol activity of acetylcholinesterase was increased while ATPase and glyceraldehyde-3-phosphate dehydrogenase activities were decreased. The alteration in the enzymatic activity occurred on those sides of the membranes, where these enzymes were localized. Activity of lactate dehydrogenase was decreased in cytoplasm of erythrocytes. The alterations detected may be important in development of ischemic syndrome in hyperlipoproteinemia.