RESUMO
The late follow-up results of combined and complex treatment of 305 patients, suffering cancer recti, were analyzed. After the operation in 250 (82%) patients the anticoagulants were administered, including the low-molecular-weight heparin (calcium nadroparine)--129 (42.3%), and nonfractionized heparin--in 121 (39.7%). In 55 (18%) patients the complex and combined treatment was conducted, according to the present standards, without application of anticoagulants. There was proved, that administration of calcium nadroparine in combined and complex treatment of patients, suffering cancer recti, had promoted the patients three-year and five-year survival indices increase due to reduction of the tumors generalization.
Assuntos
Anticoagulantes/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Heparina de Baixo Peso Molecular/uso terapêutico , Neoplasias Retais/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Anticoagulantes/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Terapia Combinada , Intervalo Livre de Doença , Feminino , Heparina de Baixo Peso Molecular/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Retais/mortalidade , Neoplasias Retais/patologia , Neoplasias Retais/cirurgiaRESUMO
The direct dependence between p53 expression in epithelial cells and the level of morphological malignant neoplasm was established as the result of investigation of expression of this biomolecular marker in 12 polyps and 35 colorectal cancer. It was shown that family cancer syndrome 1 type was observed in pedigrees of majority patients with p53 positive cancers.
Assuntos
Pólipos do Colo/genética , Neoplasias Colorretais/genética , Regulação Neoplásica da Expressão Gênica/fisiologia , Mucosa Intestinal/metabolismo , Intestino Grosso/metabolismo , Proteína Supressora de Tumor p53/metabolismo , Adulto , Idoso , Pólipos do Colo/metabolismo , Pólipos do Colo/patologia , Neoplasias Colorretais/metabolismo , Neoplasias Colorretais/patologia , Epitélio/metabolismo , Epitélio/patologia , Feminino , Humanos , Imuno-Histoquímica , Mucosa Intestinal/patologia , Intestino Grosso/patologia , Masculino , Pessoa de Meia-Idade , LinhagemRESUMO
A clinical and genealogical investigation has been carried out in 169 subjects of both sexes, presenting with colorectal oncopathology. Particular features of the colorectal carcinoma in the patients have been recognized. The frequency of the tumours spread in the relatives of the probands is determined as is the spectrum of aggregation of large intestine carcinoma with neoplasia of other genesis in the pedigrees. The data obtained suggest an important contribution of genetic factors into the origination of colorectal carcinoma.
