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1.
Int J Paediatr Dent ; 2024 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-38627936

RESUMO

BACKGROUND: Several clinical and individual factors may play a role in the survival rate of dental restorations, such as characteristics related to the child's age and oral hygiene, and factors associated with the tooth, such as the type of material and number of surfaces to be restored. AIM: To analyse the survival rate of adhesive restorations on primary teeth and factors associated with restoration survival. DESIGN: The study included dental records of children aged 3-12 years having received adhesive restorations on primary teeth at a Brazilian dental school between 2009 and 2019. A Kaplan-Meier survival curve was used to plot survival rates using the log-rank test. A multivariate Cox regression model was run to identify individual and dental factors associated with restoration failure. RESULTS: The sample comprised 269 restored teeth in 111 children. Survival curves were similar for all materials (p = .20) and types of isolation (p = .05). The annual failure rate was 3.60% for glass ionomer cement, 1.23% for resin-modified glass ionomer cement and 0.40% for composite resin. The following variables were associated with more failures: Class II restoration compared with Class I (HR = 1.96; 95%CI: 1.28-2.99, p < .001), proportion of decayed teeth (HR = 11.89; 95%CI: 2.80-50.57, p < .001) and child's age (HR = 1.17; 95%CI: 1.06-1.29, p < .001). CONCLUSION: The different materials and types of isolation had similar survival rates. Children with more decayed teeth have an increased risk of restoration failure.

2.
J Am Dent Assoc ; 155(1): 59-73.e9, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-37999659

RESUMO

BACKGROUND: Ankyloglossia is a congenital alteration that affects the tongue's mobility, influencing craniofacial development; however, its association with malocclusion is still unclear. This systematic review and meta-analysis investigated the association between ankyloglossia and malocclusion in patients. TYPES OF STUDIES REVIEWED: The authors conducted a systematic review and meta-analysis of observational studies that investigated the association between malocclusion and the presence of ankyloglossia in any age group, used any assessment tool to diagnose ankyloglossia, and considered all types of malocclusion. The authors conducted searches in 8 electronic databases through July 1, 2022. They used Joanna Briggs Institute appraisal tools to assess the methodological quality and the Grading of Recommendations, Assessment, Development and Evaluations approach to assess the certainty of the evidence. RESULTS: Eleven studies (5 cross-sectional, 6 case-control) included 2,904 patients and over 13 occlusal alterations. The certainty of the evidence ranged from low through very low. Patients with Angle Class III malocclusion had similar or more inserted lingual frenula than patients with Class I malocclusion (standard mean difference, 0.37; 95% CI, -0.50 to 1.25) and Class II malocclusion (standard mean difference, 0.55; 95% CI, -0.52 to 1.63). Patients with Class III malocclusion had clinically significant increased mouth opening reduction compared with patients with Class I malocclusion (mean difference, 6.67; 95% CI, 4.01 to 9.33) and Class II malocclusion (mean difference, 5.04; 95% CI, 2.35 to 7.72) patients. PRACTICAL IMPLICATIONS: There is uncertain evidence that ankyloglossia may be associated with the development of occlusal alterations. Ankyloglossia did not influence the Angle classification. Clinicians should closely follow children with ankyloglossia to evaluate whether this condition interferes with the occlusion. Future research should prospectively follow up on the long-term association between ankyloglossia and malocclusion. The protocol was registered a priori in the PROSPERO database (CRD42021248034). No amendments were deemed necessary after the registration of the protocol. Some subgroup analyses planned a priori were not possible, such as the severity of ankyloglossia, sex, and age, due to the lack of studies reporting data for these subgroups.


Assuntos
Anquiloglossia , Má Oclusão Classe III de Angle , Má Oclusão Classe II de Angle , Má Oclusão , Criança , Humanos , Anquiloglossia/complicações , Estudos Transversais , Má Oclusão/complicações , Má Oclusão/epidemiologia , Má Oclusão Classe III de Angle/complicações , Má Oclusão Classe II de Angle/complicações
3.
Genet Mol Biol ; 46(3): e20220377, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37695571

RESUMO

The toxic effects of venlafaxine (VLX) on aquatic organisms have already been verified and therefore are a proven matter of concern. Herein, we evaluated zebrafish embryos/adults after acute exposure to VLX. Embryos/larvae were exposed to different concentrations of VLX (100-1000 mg/L; 1.33 as a dilution factor), to evaluate mortality/developmental changos and to analyze biomarkers (0.002-100 mg/L). For adults, mortality, genotoxicity, and biomarkers were assessed in five different concentrations of VLX (1-100 mg/L). The median lethal concentration (LC50-168h) was 274.1 mg/L for embryos/larvae, and >100 mg/L for adults (LC50-96h). VLX decreased the heart rate frequency and caused premature hatching and lack of equilibrium in embryos/larvae exposed to different concentrations ranging from 100 to 562.5 mg/L. The activity of acetylcholinesterase (AChE) was inhibited in larvae exposed to 1, 25 and 100 mg/L. Glutathione-S-transferase (GST) activity was reduced in both larvae and adults after exposure to different concentrations, mainly at 25 mg/L. For both larvae and adults, lactate dehydrogenase (LDH) activity increased after 100 mg/L of VLX exposure. No DNA damage was observed in peripheral erythrocytes. Exposure to VLX may cause adverse effects on zebrafish in their early and adult life stages, interfering with embryo-larval development, and can induce physiological disturbances in adults.

4.
J Pediatr (Rio J) ; 99(5): 521-528, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37244290

RESUMO

OBJECTIVE: To compare high and low-fidelity simulations for the recognition of respiratory distress and failure in urgency and emergency pediatric scenarios. METHODS: 70 fourth-year medical students were randomly distributed in high and low-fidelity groups and simulated different types of respiratory problems. Theory tests, performance checklists, and satisfaction and self-confidence questionnaires were used in the assessment. Face-to-face simulation and memory retention was applied. The statistics were evaluated by averages and quartiles, Kappa, and generalized estimating equations. The p-value was considered 0.05. RESULTS: In the theory test there was an increase in scores in both methodologies (p < 0.001); in memory retention (p = 0.043) and at the end of the process the high-fidelity group had better results. The performance in the practical checklists was better after the second simulation (p > 0,05). The high-fidelity group felt more challenged in both phases (p = 0.042; p = 0.018) and showed greater self-confidence to recognize changes in clinical conditions and in memory retention (p = 0.050). The same group, in relation to the hypothetical real patient to be treated in the future, felt better confident to recognize respiratory distress and failure (p = 0.008; p = 0.004), and better prepared to make a systematic clinical evaluation of the patient in memory retention (p = 0.016). CONCLUSION: The two levels of simulations enhance diagnostic skills. High fidelity improves knowledge, leads the student to feel more challenged and more self-confident in recognizing the severity of the clinical case, including memory retention, and showed benefits regarding self-confidence in recognizing respiratory distress and failure in pediatric cases.


Assuntos
Síndrome do Desconforto Respiratório , Doenças Respiratórias , Humanos , Criança , Estudos Prospectivos , Emoções , Autoimagem
5.
J Clin Pediatr Dent ; 47(1): 44-49, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36627219

RESUMO

The aim of the present study was to investigate the frequency of missing data on routine dental care appointments and restorative procedures from the clinical records of children treated at a pediatric dental clinic. A descriptive retrospective study was conducted involving the clinical records of children three to 12 years of age treated only with restorations. The inclusion criteria were clinical records from the past 10 years of children with at least one restored tooth. Data collection was performed by a trained examiner who extracted information from the clinical records on appointments for routine dental care and restorative procedures. The frequency of missing data on clinical records was submitted to descriptive analysis. Among the 249 clinical records analyzed, boys accounted for little more than half (54.2%) and mean patient age was 6.9 ± 1.8 years. Ninety-four of the 249 clinical records were of appointments for routine dental care. Missing data were found for the gingival bleeding index (18.1%), visible plaque index (22.3%) and dietary logs (74.5%). Forty-seven children were submitted to a total of 618 restorative procedures. Information was missing on the type of restorative material (5%), brand of the material used (65.2%), the type of isolation (50.8%) and whether pulp capping was performed (75.9%). The percentage of missing data from clinical records was substantial, demonstrating that important information is not recorded during routine dental care or restorative procedures.


Assuntos
Cárie Dentária , Restauração Dentária Permanente , Masculino , Humanos , Criança , Pré-Escolar , Restauração Dentária Permanente/métodos , Odontopediatria , Cárie Dentária/terapia , Estudos Retrospectivos , Materiais Dentários/uso terapêutico
6.
J Biomed Mater Res B Appl Biomater ; 111(2): 261-270, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36507698

RESUMO

The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, its use in orthopedics has not yet been evaluated. Therefore, the purpose of this study was to characterize a bovine pericardium collagen membrane and evaluate the effects of its use in the regeneration of a bone defect in rat tibia. Scanning electron microscopy, atomic force microscopy, weight lost and water uptake tests, and mechanical test were performed. Afterwards, the membrane was tested in an experimental study, using 12 male Sprague Dawley rats. A bone defect was surgically made in tibiae of animals, which were assigned to two groups (n = 6): bone defect treated with collagen membrane (TG) and bone defect without treatment (CONT). Then, tibiae were submitted to micro-CT. The membranes preserved their natural collagen characteristics, presenting great strength, high water absorption, hydrophilicity, and almost complete dissolution in 30 days. In the experimental study, the membrane enhanced the growth of bone tissue in contact with its surface. A higher bone volume and trabeculae number and less trabecular space was observed in bone defects of the membrane group compared to the control group at 21 days. In conclusion, the Techgraft membrane seems to have favorable characteristics for treatment of long bone repair.


Assuntos
Regeneração Óssea , Colágeno , Bovinos , Masculino , Animais , Ratos , Ratos Sprague-Dawley , Colágeno/farmacologia , Materiais Biocompatíveis , Pericárdio , Tíbia , Água , Membranas Artificiais
7.
Int Dent J ; 73(4): 518-523, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36460521

RESUMO

AIM: The objective of this research was to compare the abrasive potential of dentifrices containing activated charcoal with those of a conventional dentifrice on the development of erosive tooth wear (ETW) in vitro. METHODS: Enamel and dentin samples were divided into toothpastes (n = 12): group (G)1-Colgate Triple Action (1450 ppm F) (positive control); G2-Colgate Natural Extracts (1450 ppm F); G3-Colgate Luminous White Activated Carbon (1450 ppm F); G4-Oral-B Whitening Therapy Charcoal (1100 ppm F); G5-Oral-B 3D White Mineral Clean (1100 ppm F); G6-Curaprox Black Is White (950 ppm F); and G7-erosion only (no abrasion, negative control). All samples were submitted to erosive pH cycles and G1 to G6 to abrasive challenges (15 seconds) using toothpastes' slurries plus 45 seconds of treatment for 7 days. The final profile was overlaid to the baseline one for the ETW calculation (µm). The data were subjected to analysis of variance/Tukey or Kruskal-Wallis/Dunn tests (P < .05). RESULTS: Oral-B 3D White (13.0 ± 1.0, 9.37 [1.36] µm), Oral-B Whitening Therapy (15.1 ± 1.2, 8.58 [1.71] µm), and Colgate Luminous White (13.6 ± 1.0, 7.46 [0.94] µm) toothpastes promoted the greatest enamel and dentin wear. On the other hand, Colgate Triple Action (12.2 ± 1.2, 5.30 [1.26] µm), Colgate Natural Extracts (10.8 ± 1.1, 4.16 [1.11] µm), and Curaprox Black Is White (11.5 ± 1.5, 4.06 [0.92] µm) toothpastes promoted lower wear values, similar to erosion only (4.16 [0.94] µm) in the case of dentin but not enamel (7.1 ± 0.8 µm). CONCLUSIONS: Toothpastes containing charcoal combined with pyrophosphate may have a high abrasive effect on eroded tooth surfaces. Many patients influenced by digital marketing use toothpastes containing activated charcoal with the aim of bleaching their teeth. However, care should be taken when using these products, as they may have a high abrasive effect.


Assuntos
Dentifrícios , Abrasão Dentária , Erosão Dentária , Humanos , Carvão Vegetal , Dentifrícios/efeitos adversos , Fluoreto de Sódio , Abrasão Dentária/etiologia , Erosão Dentária/induzido quimicamente , Escovação Dentária/efeitos adversos , Cremes Dentais/efeitos adversos
8.
Neurocase ; 29(6): 174-179, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-38704615

RESUMO

A 19-year-old student developed hypoventilation and cyanosis at the end of a cosmetic liposuction procedure. She was awake, but severely abulic, disoriented, and unable to stand and walk due to severe locomotor ataxia. Neuropsychological evaluation showed psychomotor slowness, and deficits in memory encoding and retrieval, and on executive, and visuospatial and visuoperceptual tests; oral comprehension and constructional praxis were spared. ¹H-MRS showed a reduction of NAA. A year later, her cognitive and neurological exam, and NAA returned to normal, and she resumed her normal life. The severity of the acute manifestations of hypoxic encephalopathy not always entail a poor prognosis.


Assuntos
Lipectomia , Humanos , Feminino , Adulto Jovem , Lipectomia/efeitos adversos , Ataxia/etiologia , Demência/etiologia , Recuperação de Função Fisiológica/fisiologia , Complicações Pós-Operatórias/etiologia , Testes Neuropsicológicos
9.
J. pediatr. (Rio J.) ; 99(5): 521-528, 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1514450

RESUMO

Abstract Objective: To compare high and low-fidelity simulations for the recognition of respiratory distress and failure in urgency and emergency pediatric scenarios. Methods: 70 fourth-year medical students were randomly distributed in high and low-fidelity groups and simulated different types of respiratory problems. Theory tests, performance checklists, and satisfaction and self-confidence questionnaires were used in the assessment. Face-to-face simulation and memory retention was applied. The statistics were evaluated by averages and quartiles, Kappa, and generalized estimating equations. The p-value was considered 0.05. Results: In the theory test there was an increase in scores in both methodologies (p < 0.001 ); in memory retention (p = 0.043) and at the end of the process the high-fidelity group had better results. The performance in the practical checklists was better after the second simulation (p > 0,05). The high-fidelity group felt more challenged in both phases (p = 0.042; p = 0.018) and showed greater self-confidence to recognize changes in clinical conditions and in memory retention (p = 0.050). The same group, in relation to the hypothetical real patient to be treated in the future, felt better confident to recognize respiratory distress and failure (p = 0.008; p = 0.004), and better prepared to make a systematic clinical evaluation of the patient in memory retention (p = 0.016). Conclusion: The two levels of simulations enhance diagnostic skills. High fidelity improves knowledge, leads the student to feel more challenged and more self-confident in recognizing the severity of the clinical case, including memory retention, and showed benefits regarding self-confidence in recognizing respiratory distress and failure in pediatric cases.

10.
J Am Dent Assoc ; 153(11): 1026-1040.e31, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36307175

RESUMO

BACKGROUND: Prevalence of ankyloglossia may vary depending on the assessment tool. This systematic review aimed to evaluate the prevalence of ankyloglossia in distinct age groups according to different assessment tools. TYPES OF STUDIES REVIEWED: Nine electronic databases were searched from inception through November 2021 without restrictions of language or year of publication. Paired independent reviewers selected cross-sectional and cohort studies reporting the diagnosis of ankyloglossia, extracted data, and assessed methodological quality. The number of patients with ankyloglossia and the sample were extracted to calculate the overall prevalence of ankyloglossia and 95% CI. The authors calculated the prevalence of ankyloglossia per assessment tool, age group, and sex. They assessed the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach. RESULTS: Seventy-one studies were included. Seven different diagnostic tools were used. The overall prevalence of ankyloglossia was 5% (95% CI, 4.0% to 5.0%) and ranged from 2% (using an unspecific tool) to 20% (Coryllos classification). The prevalence per age group was higher in infants (7%). The prevalence ratio was 1.34 (95% CI, 1.17 to 1.54) for boys, with very low certainty of evidence. PRACTICAL IMPLICATIONS: The prevalence of ankyloglossia is higher among infants and differs depending on the assessment tool used for the diagnosis. It is uncertain whether boys are more affected by ankyloglossia than girls.


Assuntos
Anquiloglossia , Lactente , Masculino , Feminino , Humanos , Anquiloglossia/epidemiologia , Anquiloglossia/diagnóstico , Freio Lingual , Prevalência , Estudos Transversais , Incerteza , Aleitamento Materno
11.
Animals (Basel) ; 12(14)2022 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-35883348

RESUMO

Progesterone plays an important role in initial conceptus development and in a successful pregnancy, but results related to progesterone or its analogues (altrenogest) supplementation in early pregnancy of pigs are conflicting. The present study evaluated the effects of altrenogest supplementation in sows during days 6 and 12 of pregnancy on reproductive performance. On day 6 of pregnancy, 301 females were allocated at random to one of the following treatments: CON (Control: non-supplemented females, n = 163) or ALT (females daily supplemented with 20 mg of altrenogest, orally, from day 6 to 12 of pregnancy, n = 138). Ovulation was considered as occurred at 48 h after the first estrus detection to standardize the first day of pregnancy. The supplementation increased the number of total piglets born (ALT: 17.3 ± 0.4; CON: 16.6 ± 0.4), piglets born alive (ALT: 15.6 ± 0.4; CON: 14.8 ± 0.3), and placenta weight (ALT: 4.2 ± 0.1; CON: 3.8 ± 0.1) and decreased the stillbirth rate (ALT: 5.9 ± 0.6; CON: 7.6 ± 0.6) and the number of piglets born weighing less than 800 g (ALT: 6.6 ± 0.6; CON: 8.0 ± 0.6), without impairment on farrowing rate. These results demonstrated that altrenogest supplementation on swine females between days 6 and 12 of pregnancy may be used to improve reproductive performance.

12.
Lab Chip ; 22(16): 3045-3054, 2022 08 09.
Artigo em Inglês | MEDLINE | ID: mdl-35833547

RESUMO

Thread-based microfluidic analytical devices have received growing attention since threads have some advantages over other materials. Compared to paper, threads are also capable of spontaneously transporting fluid due to capillary action, but they have superior mechanical strength and do not require hydrophobic barriers. Therefore, thread-based microfluidic devices can be inexpensively fabricated with no need for external pumps or sophisticated microfabrication apparatus. Despite these outstanding features, achieving a controlled and continuous flow rate is still a challenging task, mainly due to fluid evaporation. Here, we overcome this challenge by inserting a cotton thread into a polyethylene tube aiming to minimize fluid evaporation. Also, a cotton piece was inserted into the outlet reservoir to improve the wicking ability of the device. This strategy enabled the fabrication of an innovative electrochemical thread in a tubing microfluidic device that was capable to hold a consistent flow rate (0.38 µL s-1) for prolonged periods, allowing up to 100 injections in a single device by simply replacing the cotton piece in the outlet reservoir. The proposed device displayed satisfactory analytical performance for selected model analytes (dopamine, hydrogen peroxide, and tert-butylhydroquinone), in addition to being successfully used for quantification of nitrite in spiked artificial saliva samples. Beyond the flow rate improvement, this "thread-in-tube" strategy ensured the protection of the fluid from external contamination while making it easier to connect the electrode array to the microchannels. Thus, we envision that the thread in a tube strategy could bring interesting improvements to thread-based microfluidic analytical devices.


Assuntos
Dispositivos Lab-On-A-Chip , Técnicas Analíticas Microfluídicas , Eletrodos , Peróxido de Hidrogênio , Têxteis
13.
Pesqui. bras. odontopediatria clín. integr ; 22: e210179, 2022. tab, graf
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1422279

RESUMO

Abstract Objective: To assess the incidence of caries in a two-year period among low birth weight (LBW), very low birth weight (VLBW), and extremely low birth weight (ELBW) children considering socioeconomic indicators, dietary factors and oral hygiene. Material and Methods: A convenience sample was formed of 42 low birth weight children aged two to five years at baseline. Two examiners diagnosed caries using the World Health Organization criteria. Birth weight, socioeconomic indicators and diet were collected from medical records and questionnaires. Binomial models were used to estimate unadjusted and adjusted rate ratios (RR) and respective 95% confidence intervals for the factors evaluated. Results: Thirty-six children were re-examined after two years. The incidence of dental caries was 36.7%. The dmft index was 0.44 (±1.25) at baseline and increased to 1.36 (±3.85) at follow-up. VLBW children (1,000 to 1,500 g) (RR=0.23; 95%CI: 0.08-0.72) and LBW children (1,500 to 2,500 g) (RR=0.06; 0.01-0.55) had fewer carious lesions compared to ELBW children (<1,000 g). Carious lesions were more frequent among children with a lower income (RR=6.05; 1.05-34.84) and less frequent among those who did not consume sweetened juice, tea or yogurt (RR: 0.21; 0.07-0.62). Conclusion: An inverse dose-response relation was found between birth weight and the incidence of caries. A lower income and the consumption of sweetened beverages were risk factors for the development of caries (AU).


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Recém-Nascido de Baixo Peso , Recém-Nascido Prematuro , Criança , Saúde Bucal , Fatores de Risco , Cárie Dentária/epidemiologia , Prontuários Médicos , Incidência , Inquéritos e Questionários , Estudos de Coortes , Modelos Estatísticos , Indicadores Sociais
14.
J Clin Transl Res ; 7(2): 263-269, 2021 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-34104830

RESUMO

BACKGROUND AND AIM: Ankyloglossia is a congenital anomaly that can affect breastfeeding. The aim was to evaluate the prevalence of ankyloglossia in newborns and breastfeeding difficulties reported by mothers; assess possible factors that may interfere with breastfeeding. METHODS: A cross-sectional study was conducted with 391 pairs of mothers/newborns at a university hospital. A pediatric dentist examined the oral cavity of the newborns for the occurrence of ankyloglossia. We analyzed medical records and the mothers answered a self-administered questionnaire to assess birth variables, breastfeeding difficulties, and sociodemographic factors. We calculated prevalence ratios (PRs) of breastfeeding difficulties according to the independent variables. RESULTS: The mean age of the newborns was 2.5±2.9 days and 52% were male. The prevalence of ankyloglossia was 15% and 91.4% of mothers reported not having breastfeeding difficulties. Ankyloglossia was not associated with breastfeeding difficulties (PR: 0.5; 95% CI: 0.2-1.4). Mothers with a low income (PR: 0.5; 95% CI: 0.3-0.8), those who received instructions on breastfeeding (PR: 0.4; 95% CI: 0.2-0.9), and those who breastfed exclusively (PR: 0.3; 95% CI: 0.1-0.8) had fewer breastfeeding difficulties. CONCLUSION: Successful breastfeeding was more dependent on being born at full term, the family income, receiving guidance with regard to breastfeeding, and exclusive breastfeeding. Although ankyloglossia was not associated with breastfeeding, future prospective studies should evaluate the long-term factors that may interfere with breastfeeding. RELEVANCE FOR PATIENTS: This study brings a new perspective on the importance of assessing ankyloglossia and breastfeeding difficulties, reinforces the benefits of exclusive breastfeeding and the need for breastfeeding instructions, as well as the need to evaluate breastfeeding before making a decision regarding frenectomy.

15.
Artigo em Inglês | MEDLINE | ID: mdl-32585365

RESUMO

Fluoxetine (FLX) is among the top 100 pharmaceutical prescribed annually worldwide and consequently is often detected in wastewater treatment plant effluent and surface waters, in concentrations up to 2.7 and 0.33 µg/L, respectively. Despite the presence of FLX in surface waters, little is known about its chronic effects in fish. Thus, this study aimed at investigating the chronic toxicity of FLX to Danio rerio adults. Rate of weight gain, behavior (feeding and swimming activity) and tissue organization (liver and intestine) were evaluated, after 30 days exposure. A lower rate of weight gain was observed at 100 µg/L FLX. The food intake time decreased, showing a decrease in fish appetite. The preference for the upper aquarium layer was observed at 10 and 100 µg/L of FLX, indicating an inhibition of the stress level (anxiolytic effect). Mild to moderate damage of hepatic tissue and a decrease epithelium height and increase in villus height of intestine were observed in fish exposed to concentrations as low as 0.01 µg/L. Based on obtained results, chronic exposure of fish to FLX could affect swimming and feeding behavior and alter morphological structure of liver and intestine tissues at environmental levels.


Assuntos
Antidepressivos de Segunda Geração/toxicidade , Comportamento Animal/efeitos dos fármacos , Fluoxetina/toxicidade , Poluentes Químicos da Água/toxicidade , Peixe-Zebra/fisiologia , Animais , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/patologia , Fígado/efeitos dos fármacos , Fígado/patologia , Aumento de Peso/efeitos dos fármacos , Peixe-Zebra/anatomia & histologia , Peixe-Zebra/crescimento & desenvolvimento
16.
J Mech Behav Biomed Mater ; 104: 103662, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32174420

RESUMO

Fibrin sealant (FS) is a biomaterial that exhibits hemostatic and repairing properties. It has been successfully used as scaffolds and adhesives to improve repair and regeneration of tissues. The objective of this study was to evaluate the effect of FS in the regeneration process of bone defects in male rat tibias through macroscopic, microscopic and mechanical analysis. A bone defect of 2.9 mm was performed on the medial face of the proximal third of the tibia of 40 rats and implanted FS and autologous bone graft (AG). The animals were divided into four groups: animals with bone defect without any treatment (CON), animals treated with fibrin sealant (TFS), animals treated with autologous graft (TAG) and animals treated with fibrin sealant and autologous graft (FSAG). The animals were euthanized 42 days after surgery. Macroscopic analysis showed no difference between the groups (p > 0.05) in relation to tibial weight, but a statistically significant difference (p = 0.005) was observed for their length. Micro-computed tomography (micro-CT) revealed tendentious values regarding bone microarchitecture and FS. Bone mineral densitometry (BMD) showed significance between the FSAG (p = 0.009) and TFS (p = 0.007) groups. The bone mineral content (BMC) presented a significant difference between all groups (p = 0.020). Maximum strength showed a significant difference between the FSAG group (p = 0.007) and the others. The results obtained in relation to the relative stiffness also present a significant difference (p = 0.023). Newly formed bone showed significant differences between groups (p = 0.035). We conclude that bone defect regeneration was directly influenced by the use of FS and AG.


Assuntos
Adesivo Tecidual de Fibrina , Tíbia , Animais , Regeneração Óssea , Transplante Ósseo , Adesivo Tecidual de Fibrina/farmacologia , Masculino , Ratos , Tíbia/diagnóstico por imagem , Microtomografia por Raio-X
17.
Estud. psicol. (Natal) ; 18(2): 379-387, abr.-jun. 2013.
Artigo em Português | Index Psicologia - Periódicos | ID: psi-59340

RESUMO

Este estudo teve como objetivo analisar a compreensão que jovens de diferentes espaços e contextos da cidade de Maceió têm sobre a política, bem como, os valores que norteiam suas práticas militantes. Para tanto, foram realizados três grupos focais com jovens de 18 a 29 anos integrantes de grupos e movimentos dos âmbitos político, religioso e cultural/comunitário. Constatamos a existência de diferentes discursos a respeito da política ligados aos modos de saber-fazer de cada um dos grupos que dialogam na medida em que a política é compreendida como um instrumento de transformação social e da própria constituição dos sujeitos. Apesar das trajetórias diferenciadas dos jovens, e dos grupos de que fazem parte, nos chama a atenção o fato de que as práticas participativas e os valores que as norteiam expressam o desejo de uma juventude conectada com seu tempo que quer ser percebida como sujeito e ator social.(AU)


This study aims to analyze the understanding young people, from different places at the city of Maceió, have about the values and political beliefs that guide their practices as militants in different contexts. We conducted three focus groups with young people, from the age of 18 to 29, who are members of political, religious and cultural groups and movements. We discovered three different discourses covering topics from policy to modes of knowledge within each group. These were found to relate to their levels of understanding about the role of politics as an instrument of social transformation and the constitution of subjectivities. Despite the different life trajectories these young people and their groups have taken, we are surprised by the fact that it is through the participatory practices that express their values , that they express their aspiration to be perceived as social actors and subjects as connected to their times.(AU)


El objetivo del estudio fue analizar que percepción los jóvenes de diferentes espacios y contextos de Maceió tienen de la política, así como los valores que guían sus prácticas militantes. Así, desarrollamos tres grupos de discusión con jóvenes con edad entre 18 y 29 años, miembros de los grupos y movimientos de la vida política, religiosa y cultural / comunitaria. Identificamos la existencia de distintos discursos sobre la política relacionados con los modos de saber hacer de cada uno de los grupos que dialogan en la medida en que la política se entiende como un instrumento de transformación social y de la constitución de los sujetos. Aunque las diferentes trayectorias de los jóvenes y de los grupos a los que pertenecen llámanos la atención el hecho de que las prácticas y los valores participativos que los guían expresan el deseo de los jóvenes relacionados con su tiempo que quieren ser percibidos como sujeto y actor social.(AU)


Assuntos
Adulto Jovem , Política , Cultura
18.
Estud. psicol. (Natal) ; 18(2): 379-387, Apr.-June 2013.
Artigo em Português | LILACS | ID: lil-685467

RESUMO

Este estudo teve como objetivo analisar a compreensão que jovens de diferentes espaços e contextos da cidade de Maceió têm sobre a política, bem como, os valores que norteiam suas práticas militantes. Para tanto, foram realizados três grupos focais com jovens de 18 a 29 anos integrantes de grupos e movimentos dos âmbitos político, religioso e cultural/comunitário. Constatamos a existência de diferentes discursos a respeito da política ligados aos modos de saber-fazer de cada um dos grupos que dialogam na medida em que a política é compreendida como um instrumento de transformação social e da própria constituição dos sujeitos. Apesar das trajetórias diferenciadas dos jovens, e dos grupos de que fazem parte, nos chama a atenção o fato de que as práticas participativas e os valores que as norteiam expressam o desejo de uma juventude conectada com seu tempo que quer ser percebida como sujeito e ator social...


This study aims to analyze the understanding young people, from different places at the city of Maceió, have about the values and political beliefs that guide their practices as militants in different contexts. We conducted three focus groups with young people, from the age of 18 to 29, who are members of political, religious and cultural groups and movements. We discovered three different discourses covering topics from policy to modes of knowledge within each group. These were found to relate to their levels of understanding about the role of politics as an instrument of social transformation and the constitution of subjectivities. Despite the different life trajectories these young people and their groups have taken, we are surprised by the fact that it is through the participatory practices that express their values , that they express their aspiration to be perceived as social actors and subjects as connected to their times...


El objetivo del estudio fue analizar que percepción los jóvenes de diferentes espacios y contextos de Maceió tienen de la política, así como los valores que guían sus prácticas militantes. Así, desarrollamos tres grupos de discusión con jóvenes con edad entre 18 y 29 años, miembros de los grupos y movimientos de la vida política, religiosa y cultural / comunitaria. Identificamos la existencia de distintos discursos sobre la política relacionados con los modos de saber hacer de cada uno de los grupos que dialogan en la medida en que la política se entiende como un instrumento de transformación social y de la constitución de los sujetos. Aunque las diferentes trayectorias de los jóvenes y de los grupos a los que pertenecen llámanos la atención el hecho de que las prácticas y los valores participativos que los guían expresan el deseo de los jóvenes relacionados con su tiempo que quieren ser percibidos como sujeto y actor social...


Assuntos
Humanos , Cultura , Política , Adulto Jovem
19.
Pesqui. bras. odontopediatria clín. integr ; 8(1): 111-115, jan.-jun. 2008. tab
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-521956

RESUMO

Histopatológicos em uma série de casos de fibromas ossificantes centrais (FOCs) e displasias fibrosas (DFs) dos ossos maxilares. Método: Análise retrospectiva de FOCs e DFs dos ossos maxilares diagnosticados no Serviço de Patologia Oral do Departamento de Odontologia da UFRN, no período compreendido entre janeiro de 1970 e janeiro de 2007. Foram avaliados dados clínicos referentes ao sexo e idade dos pacientes e localização anatômica das lesões. Através de exames radiográficos panorâmicos, FOCs e DFs foram avaliados quanto à densidade radiográfica e ao limite da lesão em relação ao tecido ósseo circunvizinho. Para o estudo histopatológico, FOCs e DFs foram avaliados quanto à morfologia, grau de maturação e atividade osteoblástica do tecido mineralizado, bem como quanto à celularidade, vascularização e colagenização do tecido conjuntivo. Resultados: Foram constatados 15 FOCs e 13 DFs, os quais revelaram marcante predileção pelo sexo feminino. Em relação à localização anatômica, 66,7% dos FOCs acometeram a mandíbula e 69,2% das DFs se apresentaram em maxila. Em particular, 90% dos FOCs de mandíbula e 66,7% das DFs localizadas em maxila acometeram as regiões posteriores destes ossos. Radiograficamente, FOCs e DFs demonstraram densidade predominantemente mista ou radiopaca. Todos os FOCs se apresentaram como lesões circunscritas e 100% das DFs revelaram limites radiográficos difusos.


Assuntos
Humanos , Masculino , Feminino , Diagnóstico Diferencial , Fibroma Ossificante , Displasia Fibrosa Monostótica , Mandíbula , Maxila , Radiografia Panorâmica/métodos , Interpretação Estatística de Dados
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