A prospective controlled randomized multicenter study to evaluate the severity of compensatory sweating after one-stage bilateral thoracic sympathectomy versus unilateral thoracic sympathectomy in the dominant side.

OBJECTIVE: To evaluate the contribution that unilateral thoracic sympathectomy in dominant side or two-stage bilateral thoracic sympathectomy can have as strategies to reduce the incidence of compensatory sweating after sympathectomy for palmar hyperhidrosis. METHODS: This is a prospective, controlled, randomized multicenter trial of 200 participants with palmar hyperhidrosis, which will be randomized into two arms: (a) one-stage bilateral thoracic sympathectomy (control arm); or (b) unilateral thoracic sympathectomy in dominant side (intervention arm). At six months the participants submitted to unilateral procedure can make the contralateral surgery if they wanted it, creating a third group called two-stage bilateral sympathectomy. Participants will be evaluated for the degree of sweating by the Hyperhidrosis Disease Severity Scale (HDSS) and of quality of life questionnaires. RESULTS: 96 participants out of the 200 proposed have been included so far, with 48 participants randomized to each arm. From the sample 61 (63.5%) are female, with a mean age of 24 (20-32) years. There were exclusive palmar hiperhydrosis in 14 cases (14.5%), palmar and plantar hyperhidrosis in 36 (37.5%) cases, palmar and axillar hyperhidrosis in 12 (12,5%) cases and palmar-axillary-plantar hyperhidrosis in 34 (35,4%) cases. The age at the beginning of the disease was childhood (78%), with mean of time of disease 15 (11-22) years. CONCLUSIONS: If one or both hypothesis: (a) unilateral sympathectomy in dominant hand is a satisfactory treatment; b) two-stage bilateral sympathectomy causes less compensatory sweating than in one stage are confirmed there is a chance that surgical therapy for palmar hyperhidrosis can be changed for better.

Effects of 2 Types of Resistance Training Models on Obese Adolescents' Body Composition, Cardiometabolic Risk, and Physical Fitness.

Magnani Branco, BH, Carvalho, IZ, Garcia de Oliveira, H, Fanhani, AP, Machado dos Santos, MC, Pestillo de Oliveira, L, Macente, SB, and Nelson, NJ. Effects of 2 types of resistance training models on obese adolescents' body composition, cardiometabolic risk, and physical fitness. J Strength Cond Res 34(9): 2672-2682, 2020-The main objective of this study was to investigate the effects of 2 types of resistance training (RT) models in conjunction with interdisciplinary interventions by other health professionals to reduce the body fat and cardiometabolic risk of obese adolescents while improving their general health-related physical fitness. The 12-week analyses involved 18 male adolescents who were split into 2 groups (weight lifting: n = 9 and functional: n = 9), with equalization according to the primary muscle group (whenever possible), the effort:pause ratio, and intensity. The results showed reductions in fat mass and body fat, as well as in waist and hip circumferences (p < 0.05) after the intervention period. However, no significant differences were observed in terms of the body mass, body mass index, neck circumference, systolic and diastolic blood pressures, and for lean mass (p > 0.05) after the respective period. Maximal isometric strength, abdominal strength resistance, flexibility, and maximal oxygen consumption all produced significant increases after the interventions (p < 0.05). There were reductions in low-density lipoproteins and triglyceride levels after the intervention period (p < 0.05). For fasting glycemia, high-density lipoproteins, and alanine aminotransferase, no differences were observed (p > 0.05). In addition, no differences were observed in rating of perceived recovery, internal training load, or caloric intake (p > 0.05). With the results presented, it is concluded that both RT methods were effective at reducing both fat mass and body fat, thus improving health-related physical fitness components and decreasing cardiometabolic risk.

A perda urinária é frequente em pacientes com Doença Pulmonar Obstrutiva Crônica (DPOC) atendidos ambulatorialmente / Urinary leakage is frequent in outpatient chronic obstructive pulmonary disease (COPD) patients

INTRODUÇÃO: A incontinência urinária (IU) é definida como qualquer perda involuntária de urina, sendo a tosse um fator de risco. A tosse é um sintoma frequente da Doença Pulmonar Obstrutiva Crônica (DPOC) podendo associar-se com a IU. Objetivo: Avaliar a frequência de perda urinária e o impacto da IU na qualidade de vida das pessoas com DPOC e caracterizar a presença de tosse. MATERIAL E MÉTODOS: Tratou-se de um estudo descritivo, realizado em pessoas com DPOC. A coleta dos dados foi realizada no Departamento de Ciências da Vida II/UNEB. Aplicou-se o International Consultation Incontinence Short-Form (ICIQ-SF) para avaliar a frequência de perda urinária e o King's Health Questionnaire (KHQ) para o impacto na qualidade de vida. Os dados foram analisados no software SPSS (v.22.0), descritos em medida de tendência central, dispersão e proporções. Um p < 0,05 foi considerado estatisticamente significante. RESULTADOS: Das 30 pessoas avaliadas, a média da idade foi 66,7± 8,6 anos; desses 11 (36,7%) apresentaram queixa de IU, sendo sete (63,3%) mulheres. Entre esses a média de pontuação do ICIQ-SF foi de 5,9± 4,4. Vinte e oito participantes (93,3%) tinham tosse crônica. Analisando o KHQ, o domínio de maior impacto foi "percepção geral de saúde''. CONCLUSÃO: A frequência de IU em pessoas com DPOC foi de 35,7% e a de tosse foi de 93,3%. Entre as pessoas com perda urinária, 36,7% referiram alguma interferência na vida diária. É importante incluir a avaliação da IU para ampliar o manejo clínico da condição de saúde dessas pessoas.

INTRODUCTION: Urinary incontinence (UI) is defined as any involuntary leakage of urine in which cough is a risk factor. Cough is a common symptom of chronic obstructive pulmonary disease (COPD) and may be associated with UI. OBJECTIVE: To evaluate the urinary leakage frequency and the UI impact in the life's quality of people with copd and characterizing the cough presence. MATERIAL AND METHODS: This was a descriptive study conducted in people with COPD. Data collection was performed at the Department of Life Sciences II/ UNEB. The International Consultation Incontinence Short-Form (ICIQSF) was applied to assess the frequency of urinary leakage and the King's Health Questionnaire (KHQ) for the impact on quality of life. Data were analyzed using SPSS software (v.22.0), described as central tendency, dispersion and proportions and p<0.05 was considered statistically significant. RESULTS: Thirty people were evaluated with the mean age 66.7±8.6 years. Eleven people (36.7%) complained of UI, seven (63.3%) were women. The average ICIQ-SSF score was 5.9±4.4. Twentyeight participants (93.3%) had chronic cough. The domain of greatest impact of the KHQ was "general health perception". CONCLUSION: UI frequency in people with COPD was 35.7% and cough was 93.3%. People with leakage urinary (36,7%) reported some interference in daily life. It is important to include UI assessment to be clear the clinical management of their health status.

MB-Isoster: A software for bioisosterism simulation.

Bioisosterism is a technique used in medicinal chemistry to optimize lead compounds in drug research. One can replace a substituent group in original molecule by another with similar physical chemistry properties and then test how this replacement affects biological activity. To help researchers in their bioisosteric replacement choose, computational efforts such as programs and databases was developed. In this article, it is presented MB-Isoster, a software that draws bioisosteric molecules. Starting from an input molecule, user selects a molecular subregion formed by connected atoms to be replaced and MB-Isoster queries an internal library to find bioisosteric substituents for selected subregion, and makes the bioisosteres. Another functionality is receptor-ligand pdb complex reading, in which nonbonded interactions are computed between receptor and ligand in a pdb file, helping in atom/subregion selection to bioisosteric replacement. Physical-chemical properties computing, and virtual screening evaluation is also available. MB-Isoster is freely available at http://molmod-cs.unifal-mg.edu.br/tools.html. © 2018 Wiley Periodicals, Inc.

Massive hemoptysis successfully treated with extracorporeal membrane oxygenation and endobronchial thrombolysis. / Hemoptise maciça tratada com oxigenação por membrana extracorpórea e trombolítico endobrônquico com sucesso.

Extracorporeal membrane oxygenation has been used to treat refractory hypoxemia in numerous clinical scenarios. The fundamental principles for the management of massive hemoptysis patients include protecting the airway and healthy lung, locating the source of bleeding and controlling the hemorrhage. We report the case of a patient with acute respiratory failure associated with massive hemoptysis secondary to lung laceration during cardiac surgery. The use of extracorporeal membrane oxygenation allowed patient survival. However, due to the great difficulty in managing pulmonary clots after hemoptysis, it was necessary to use an unusual therapy involving endobronchial infusion of a thrombolytic agent as described in rare cases in the literature.

Hemoptise maciça tratada com oxigenação por membrana extracorpórea e trombolítico endobrônquico com sucesso / Massive hemoptysis successfully treated with extracorporeal membrane oxygenation and endobronchial thrombolysis

RESUMO A oxigenação por membrana extracorpórea tem sido utilizada para tratamento de hipoxemia refratária em muitos cenários clínicos. Os princípios fundamentais do manejo do paciente com hemoptise maciça são a proteção da via aérea e do pulmão sadio, a localização da fonte de sangramento e o controle da hemorragia. Relatamos o caso de uma paciente com insuficiência respiratória aguda associada à hemoptise maciça secundária à laceração pulmonar durante cirurgia cardíaca. O uso da oxigenação por membrana extracorpórea venoarterial permitiu a sobrevivência da paciente, porém, devido à grande dificuldade no manejo dos coágulos pulmonares após hemoptise, foi necessário o uso de terapia incomum, com infusão endobrônquica de trombolítico, conforme descrito em raros casos na literatura.

ABSTRACT Extracorporeal membrane oxygenation has been used to treat refractory hypoxemia in numerous clinical scenarios. The fundamental principles for the management of massive hemoptysis patients include protecting the airway and healthy lung, locating the source of bleeding and controlling the hemorrhage. We report the case of a patient with acute respiratory failure associated with massive hemoptysis secondary to lung laceration during cardiac surgery. The use of extracorporeal membrane oxygenation allowed patient survival. However, due to the great difficulty in managing pulmonary clots after hemoptysis, it was necessary to use an unusual therapy involving endobronchial infusion of a thrombolytic agent as described in rare cases in the literature.

Video-assisted thoracoscopic surgery yields better outcomes than thoracotomy for anatomical lung resection in Brazil: a propensity score-matching analysis using the Brazilian Society of Thoracic Surgery database.

OBJECTIVES: The use of video-assisted anatomical lung resection is increasingly widespread for lung cancer and non-neoplastic diseases, showing excellent results. Nonetheless, a comparative analysis of the benefits of this technique has yet to be conducted in Latin America, a region with a completely different case mix from the USA or Europe. The purpose of this study was to compare the outcomes of video-assisted thoracoscopic surgery (VATS) and open thoracotomy (OT) for anatomical lung resection in patients included on the Brazilian Society of Thoracic Surgery (BSTS) database. METHODS: Using propensity score matching, we conducted an analysis of 1355 patients who underwent anatomical lung resection (704 OT and 651 VATS) registered in the BSTS database between August 2015 and December 2016. Propensity score matching was performed using the following baseline characteristics: age at surgery, gender, comorbidities, pulmonary lung function, type of resection and cancer and non-cancer diagnosis. The propensity score-matched sample comprised a well-matched group of 890 patients. The main outcomes tested were mortality, complications and major cardiopulmonary complications based on the European Society of Thoracic Surgeons (ESTS) database definitions and terminology. RESULTS: Standardized differences of means and proportions suggested that an adequate balance had been achieved. Major cardiopulmonary complications were shown to be more frequent in patients who underwent OT (16.0% compared with 9.2% in VATS patients; odds ratio = 1.87, 95% confidence interval 1.25-2.80) and the overall complications rate was higher among patients who underwent OT (30.1% compared with 21.8% in VATS patients; odds ratio = 1.55, 95% confidence interval 1.17-2.05). No statistically significant difference in mortality rate was observed between OT (2.5%) and VATS (1.8%) (odds ratio = 1.38, 95% confidence interval 0.54-3.50). CONCLUSIONS: In Brazil, the rate of complications associated with minimally invasive surgery (VATS) for anatomical lung resection is significantly lower than that of conventional OT.

Adolescer na contemporaneidade: uma crise dentro da crise / Adolescent in contemporary: a crisis within the crisis

Resumo: Há tempos, a psicanálise tem demonstrado as crises que marcam o mundo contemporâneo. O lugar claudicante do pai, a inconsistência do Outro e o imperativo de gozo são marcas do discurso capitalista atual. Diante desse cenário, outra crise ganha espaço nas discussões sobre clínica e sociedade. Trata-se da experiência da puberdade e das séries de respostas que se reúnem em torno do que é chamado de crise da adolescência. O presente artigo se propõe a identificar as especificidades tanto da puberdade quanto do momento histórico em que vivemos para assim colaborar com a discussão sobre o adolescer na sociedade contemporânea

Abstract: Psychoanalysis has long demonstrated the crises that mark the contemporary world. The halting place of the father, the inconsistency of the Other and the imperative of enjoyment are trademarks of today´s capitalist discourse. Given this scenario, another crisis is gaining ground in discussions of clinical and society. This refers to the experience of puberty and the series of responses that come together around what is called the crisis of adolescence. In order to collaborate with the discussion of the adolescent in contemporary society, this article aims to identify the specificities of puberty and the historical moment in which we live.

Contribution of the Unified Health Care System to mammography screening in Brazil, 2013.

OBJECTIVE: To estimate the coverage of opportunistic mammography screening performed via the Brazilian Sistema Único de Saúde (SUS, Unified Health Care System), at the state and regional level, in 2013. MATERIALS AND METHODS: This was an ecological study in which coverage was estimated by determining the ratio between the number of mammograms performed and the expected number of mammograms among the population of females between 50 and 69 years of age. The number of mammograms performed in the target population was obtained from the Outpatient Database of the Information Technology Department of the SUS. To calculate the expected number of mammograms, we considered 58.9% of the target population, the proportion that would be expected on the basis of the recommendations of the Brazilian National Cancer Institute. RESULTS: In 2013, the estimated national coverage of mammography screening via the SUS was 24.8%. The mammography rate ranged from 12.0% in the northern region to 31.3% in the southern region. When stratified by state, coverage was lowest in the state of Pará and highest in the state of Santa Catarina (7.5% and 35.7%, respectively). CONCLUSION: The coverage of mammography screening performed via the SUS is low. There is a significant disparity among the Brazilian states (including the Federal District of Brasília) and among regions, being higher in the south/southeast and lower in the north/northeast.

OBJETIVO: Estimar a cobertura mamográfica em rastreamento oportunista realizado pelo Sistema Único de Saúde (SUS) no Brasil, nas suas regiões e nas Unidades da Federação, no ano de 2013. MATERIAIS E MÉTODOS: Estudo ecológico, em que a estimativa da cobertura foi a proporção entre o número de exames realizados e o número de exames esperados na população feminina na faixa etária de 50 a 69 anos. O número de exames realizados refere-se aos dados da produção mamográfica da população alvo, disponíveis no Sistema de Informações Ambulatoriais do Departamento de Informática do SUS. Para o cálculo do número de exames esperados considerou-se 58,9% da população alvo, tendo em vista as recomendações do Instituto Nacional de Câncer. RESULTADOS: A estimativa da cobertura mamográfica no rastreamento realizado pelo SUS no Brasil, em 2013, foi 24,8%. A prevalência de mamografias variou de 12,0% na Região Norte a 31,3% na Região Sul. Ao estratificar por Unidades da Federação, a menor cobertura foi no Pará (7,5%) e a maior cobertura foi em Santa Catarina (35,7%). CONCLUSÃO: A cobertura mamográfica do SUS no Brasil é baixa. Existe uma desigualdade significativa entre as Unidades da Federação, sendo maior nas regiões Sul e Sudeste e menor nas regiões Norte e Nordeste do país.

Contribution of the Unified Health Care System to mammography screening in Brazil, 2013 / Contribuição do Sistema Único de Saúde no rastreamento mamográfico no Brasil, 2013

Abstract Objective: To estimate the coverage of opportunistic mammography screening performed via the Brazilian Sistema Único de Saúde (SUS, Unified Health Care System), at the state and regional level, in 2013. Materials and Methods: This was an ecological study in which coverage was estimated by determining the ratio between the number of mammograms performed and the expected number of mammograms among the population of females between 50 and 69 years of age. The number of mammograms performed in the target population was obtained from the Outpatient Database of the Information Technology Department of the SUS. To calculate the expected number of mammograms, we considered 58.9% of the target population, the proportion that would be expected on the basis of the recommendations of the Brazilian National Cancer Institute. Results: In 2013, the estimated national coverage of mammography screening via the SUS was 24.8%. The mammography rate ranged from 12.0% in the northern region to 31.3% in the southern region. When stratified by state, coverage was lowest in the state of Pará and highest in the state of Santa Catarina (7.5% and 35.7%, respectively). Conclusion: The coverage of mammography screening performed via the SUS is low. There is a significant disparity among the Brazilian states (including the Federal District of Brasília) and among regions, being higher in the south/southeast and lower in the north/northeast.

Resumo Objetivo: Estimar a cobertura mamográfica em rastreamento oportunista realizado pelo Sistema Único de Saúde (SUS) no Brasil, nas suas regiões e nas Unidades da Federação, no ano de 2013. Materiais e Métodos: Estudo ecológico, em que a estimativa da cobertura foi a proporção entre o número de exames realizados e o número de exames esperados na população feminina na faixa etária de 50 a 69 anos. O número de exames realizados refere-se aos dados da produção mamográfica da população alvo, disponíveis no Sistema de Informações Ambulatoriais do Departamento de Informática do SUS. Para o cálculo do número de exames esperados considerou-se 58,9% da população alvo, tendo em vista as recomendações do Instituto Nacional de Câncer. Resultados: A estimativa da cobertura mamográfica no rastreamento realizado pelo SUS no Brasil, em 2013, foi 24,8%. A prevalência de mamografias variou de 12,0% na Região Norte a 31,3% na Região Sul. Ao estratificar por Unidades da Federação, a menor cobertura foi no Pará (7,5%) e a maior cobertura foi em Santa Catarina (35,7%). Conclusão: A cobertura mamográfica do SUS no Brasil é baixa. Existe uma desigualdade significativa entre as Unidades da Federação, sendo maior nas regiões Sul e Sudeste e menor nas regiões Norte e Nordeste do país.

O “Nostálgico” e o “Contemporâneo”: algumas considerações sobre o lugardo psicanalista no século XXI / The “Nostalgic” and the “Contemporary”: some considerations about the position of the psychoanalyst in the twenty-first century

Se o sujeito é efeito do encontro do corpo vivente com o Outro, as mudanças sociais,econômicas e políticas no campo do Outro provocam também mudanças subjetivas e clínicas.Diante das novidades de seu tempo, o psicanalista deve escutar os novos arranjos dos sintomase os desafios de sua época. O psicanalista deve ser crítico, porém deve evitar ocupar tanto aposição de “nostálgico”, quanto posição de “bem ajustado” ao seu tempo. O presente artigoapresenta uma contribuição sobre o lugar do psicanalista no século XXI, a partir de um debate sobre o que é ser “nostálgico” e o que é ser “contemporâneo” do ponto de vista da psicanálise freudiana e da filosofia de Giorgio Agamben

Estudo comparativo da diferenciação osteogênica das células tronco mesenquimais da medula óssea e do tecido adiposo de cães adultos / Comparative study of the osteogenic differentiation of mesenchymal stem cells from bone marrow and adipose tissue of adult dogs

O objetivo deste estudo foi comparar o potencial osteogênico das células tronco mesenquimais extraídas da medula óssea (CTM-MO) com as do tecido adiposo (CTM-AD) de cães adultos. As células foram caracterizadas fenotipicamente quanto à expressão de CD29, CD90, CD34 e CD45 e submetidas à diferenciação adipogênica e condrogênica por 21 dias e osteogênica por 7, 14 e 21 dias. Foram constituídos quatro grupos: 1) CTM-MO em meio osteogênico, 2) CTM-MO em meio basal, 3) CTM-AD em meio osteogênico e 4) CTM-AD em meio basal. Aos 7, 14 e 21 dias de diferenciação osteogênica as culturas foram submetidas às avaliações da conversão de MTT em formazan, da atividade da fosfatase alcalina (FA), da síntese de colágeno e de matriz mineralizada, avaliação do número de células por campo e foram quantificados os transcritos gênicos para osterix, sialoproteina óssea (BSP), osteonectina (ON) e osteocalcina (OC). Tanto as células extraídas da medula óssea quanto do tecido adiposo mostraram elevada expressão de marcadores para células tronco e baixa expressão de marcadores de células hematopoiéticas (menor que 2%). Além disso, foram capazes de se diferenciar em osteoblastos, condrócitos e adipócitos. As CTM-AD submetidas à diferenciação osteogênica mostraram maior conversão do MTT em formazan que as CTM-MO, sob mesmas condições aos 7 e 21 dias. O número de células por campo, a atividade da FA, a síntese de colágeno e de matriz mineralizada foram superior nas CTM-AD em diferenciação, em relação às CTM-MO sob as mesmas condições, em todos os tempos estudados. As expressões de osterix, BSP e OC foram predominantemente superiores nas CTM-MO diferenciadas, mas a expressão de ON foi superior nas CTM-AD diferenciadas aos 7, 14 e 21 dias. Conclui-se que as CTM-AD apresentam maior potencial osteogênico que as CTM-MO quando extraídas de cães adultos.(AU)

The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. The cells were phenotypically categorized according to the expression of CD29, CD90, CD34 and CD45, and submitted to adipogenic and chondrogenic differentiation for 21 days and osteogenic differentiation for 7, 14 and 21 days. Four groups were formed: BM-MSC in osteogenic medium (1), BM-MSC in basal medium (2), AT-MSC in osteogenic medium (3) and ATMSC in basal medium (4). On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). Both the cells obtained from bone marrow and those from adipose tissue showed high expression of stem cells markers and low expression of hematopoietic cells markers (lower than 2%). Besides, they were able to differentiate into osteoblasts, chondrocytes and adipocytes. AT-MSC submitted to osteogenic differentiation showed higher MTT conversion in formazan than BM-MSC, under the same conditions on days 7 and 21. The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. Expressions of osterix, BSP and OC were predominantly higher in differentiated BMMSC, however the expression of ON was higher AT-MSC differentiated on days 7, 14 and 21. In conclusion, AT-MSC present higher osteogenic potential than BM-MSC when extracted from adult dogs.(AU)

"Arquitetura da destruição" e a segregação cotidiana na cultura / "Architecture of doom" and the daily segregation in culture / "Arquitectura de la destrucción" y la segregación cotidiana en la cultura / "Architecture of destruction" et la ségrégation quotidienne dans la culture

A partir de breve resenha sobre o documentário Arquitetura da Destruição, pretende-se destacar uma discussão acerca da segregação cotidiana na sociedade atual. Parte-se da tese lacaniana de 2003 exposta na Proposição de 9 de Outubro de 1967 sobre o Psicanalista da Escola, que indica três pontos que deveriam ser preocupação dos psicanalistas: uma escola de formação em psicanálise hierarquizada, o Complexo de Édipo e os campos de concentração. Lacan destaca o engendramento dos últimos dois conceitos como a dinâmica que a sociedade incorporou ao cotidiano, como um paradigma da subjetividade contemporânea. O esvaziamento dos sujeitos, tal e qual acontece nos campos de concentração, é percebido também numa cultura que privilegia as relações pautadas pela lógica mercadológica. À parte, a diferença entre se tratar de um esvaziamento forçado (no regime nazista) ou não (sociedade de mercado), o fato é que a alienação ao Outro e ao próprio gozo aparecem como elementos centrais na manutenção da segregação social. Se o discurso hitlerista de harmonia e eugenia teve eco social, foi justamente no ponto em que se arregimentava um Outro poderoso o bastante para que seu desejo de domínio suplantasse a anulação dos que se submeteram a ele. Seguindo tal indicação, o artigo enfatiza ao seu final a relação contemporânea que se constrói entre cidadania e gozo.

From a brief summary of the documentary Architecture of Doom, this article intends to highlight a discussion about segregation in contemporary society. It starts with the Lacanian thesis of 2003 exposed in Proposition 9 October 1967 on the Psychoanalyst of the School, which indicates three points that should concern psychoanalysts: a hierarchical school for training in psychoanalysis, the Oedipus Complex and the concentration camps. Lacan emphasizes the engenderment of the last two concepts as the dynamic that society has incorporated to everyday life, as a paradigm of contemporary subjectivity. The subjects' emptying, as it happens in concentration camps, can also be perceived in a culture that emphasizes relationships guided by market logic. Apart from the difference between the case of a forced emptying (in the Nazis regime) or not (market society), the fact is that the alienation to the Other or to the own enjoyment appears as central elements in the maintenance of social segregation. If Hitler's discourse about harmony and eugenics had social resonance, it was precisely in the point at which it deployed an enough powerful Other that his desire for domain supplants the annihilation of those who have submit to him. Following this statement, the article emphasizes the contemporary relationship construct between citizenship and enjoyment.

Partiendo de una breve reseña acerca del documental Arquitectura de la Destrucción, se pretende resaltar una discusión acerca de la segregación cotidiana en la sociedad actual. Se inicia de la tesis lacaniana de 2003, expuesta en la Proposición de 9 de octubre de 1967 acerca del Psicoanalista de la Escuela, la cual apunta para tres puntos que deberían preocupar a los psicoanalistas: una escuela de formación en psicoanálisis jerarquizada, el Complejo de Édipo y los campos de concentración. Lacan subraya el origen de los dos últimos conceptos como la dinámica que la sociedad incorporó al cotidiano, como un paradigma de la subjetividad contemporánea. El vaciado de los sujetos, como ocurre en los campos de concentración, es percibido también en una cultura donde se privilegia las relaciones basadas en la lógica mercadológica. Quitando la diferencia entre tratar un vaciado forzado (régimen nazi) o no (sociedad de mercado), el hecho es que la alienación al Otro y al gozo propio surge como elementos centrales en la manutención de la segregación social. Si el discurso hitlerista de harmonía y depuración racial tuvo resonancia social, fue justamente en el punto en que convocaba un Otro poderoso lo suficiente para que su deseo de dominio derrumbase la anulación de los que se sometieron a él. Siguiendo esta indicación, el artículo enfatiza al final la relación contemporánea que es construida entre ciudadanía y gozo.

Une brève introduction de la Architecture of Doom documentaire est destiné à mettre en évidence une discussion au sujet de la ségrégation dans la société de tous les jours. Il commence avec la thèse lacanienne exposé dans Proposition 9 Octobre 1967 concernant le psychanalyste de l'École (2003), ce qui indique trois points qui devraient être la préoccupation des psychanalystes: une école de formation en psychanalyse hiérarchique, le complexe d'OEdipe et les champs concentration. Lacan met l'accent sur la sexuation du passé que la société dynamique qui intègre le quotidien comme un paradigme de la subjectivité contemporaine. La vidange du sujet, comme cela se passe dans les camps de concentration, il est également perçue dans une culture qui met l'accent sur les relations guidés par la logique du marché. En dehors de la différence entre le cas d'une évacuation forcée (les nazis) ou non (société de marché), le fait est que la vente à une autre joie de posséder et d'apparaître comme des éléments centraux dans le maintien de la ségrégation sociale. Si le discours Hitler harmonie et l'eugénisme ont eu une résonance sociale, c'est précisément le moment où enrôle une Autre assez puissant que son désir de supplanter l'annulation du domaine qui ont subi cela. Suite à cette déclaration, l'article met l'accent sur sa relation contemporaine finale qui construit entre la citoyenneté et la jouissance.

Effect of the ionic product of bioglass 60s on osteoblastic activity in canines.

BACKGROUND: The objective of the present study was to evaluate the effect of the ionic product (IP) of BG60S on osteoblastic activity. The following media groups were created: DMEM, which is formed by osteoblasts in basal medium; IP DMEM, which is formed by osteoblasts in IP with basal medium; OST, which is formed by osteoblasts in osteogenic medium; and IP OST, which is formed by osteoblasts in IP with osteogenic medium. The osteoblasts were cultivated in an incubator at 37 °C and 5 % CO2 for 7, 14 and 21 days. After each period, the alkaline phosphatase (AP) activity, mineralised area per field and expression of osterix (OSX), bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC) were evaluated by reverse transcription (RT)-PCR. RESULTS: The IP significantly increased the AP activity in the IP DMEM group at 7 and 14 days and reduced the AP activity in the IP OST group at 14 and 21 days relative to their respective controls (DMEM and OST). The groups that received the IP displayed a significant increase in the percentage of mineralised area per field and more advance maturation of the extracellular matrix relative to those that did not receive IP. The IP significantly increased the expression of OSX, BSP and ON in osteoblast cultures maintained in IP DMEM compared with the control (DMEM) for the majority of studied periods. In osteogenic medium, IP also significantly increased OSX, BSP, ON and OC expression compared with the control (OST) for the majority of studied periods. CONCLUSIONS: The IP of BG60S alters the gene expression of canine osteoblasts, favouring the synthesis and mineralisation of the extracellular matrix.

As primeiras sessões com Sara, a colaborativa: uma adolescente à procura de suas asas / Las primeras sesiones con Sara, la colaborativa: una adolescente en busca de sus alas / First sessions with Sara, the collaborator: a teenager that is seeking her wings

O presente artigo tem o propósito de pensar o lugar do adolescente na clínica psicanalítica, ressaltando como o fracasso do Outro provocado pela puberdade pode levar o sujeito a respostas sintomáticas graves. Para isso, o início da análise de uma adolescente de 17 anos e seu pensamento suicida serão examinados a partir de dois outros curtos tratamentos empreendidos por Freud: o Caso Dora e o Caso da Jovem Homossexual.

This paper has the purpose of thinking about the adolescents' place in the psychoanalytic clinical practice. This study emphasizes the way the failure of the Other caused by puberty may lead the subject to severe symptomatic responses. To that end and starting from two other short treatments provided by Freud (Dora's and the Young Homosexual's Case), the author will examine the beginning of a 17-yearold adolescent psychoanalysis and her suicidal thoughts.

Este artículo tiene como objetivo reflexionar sobre el lugar de los adolescentes en la práctica psicoanalítica, destacando cómo el fracaso del Otro causado por la pubertad puede llevar al sujeto a respuestas sintomáticas graves. Para ello, y con base en otros dos tratamientos cortos realizados por Freud - el Caso Dora y el Caso de la Joven Homosexual -, se examinarán el principio del análisis de una adolescente de 17 años y sus pensamientos suicidas.

O intercâmbio impossível da adolescência: análise pscinalítica sobre o despertar da sexualidade por meio do filme "Hoje eu quero voltar sozinho" de Daniel Ribeiro / The impossible exchange of adolescence: a psychoanalytic analysis of the awakening of sexuality through the movie "The way he looks", by Daniel Ribeiro / El intercambio imposible de la adolescencia: análisis psicoanalítico del despertar de la sexualidad a través de la película "Hoy quiero volver solito" de Daniel Ribeiro

O presente artigo visa discutir, a partir do filme Hoje eu quero voltar sozinho, do diretor brasileiro Daniel Ribeiro, a maneira como a Psicanálise pensa a sexualidade humana, encarando-a sempre como uma construção. Para essa reflexão, serão destacados três aspectos do filme: o despertar para a homossexualidade do protagonista, sua cegueira e sua passagem pela adolescência. Esses aspectos serão relacionados entre si através de conceitos de Freud e Lacan que abordem a relação entre a pulsão sexual e seu objeto.(AU)

This paper discusses, from the movie The way he looks, by Brazilian director Daniel Ribeiro, the way psychoanalysis thinks human sexuality, always viewing it as a construction. For this reflection, three aspects of the film will be highlighted: the awakening of the protagonist's homosexuality, his blindness and his passage through adolescence. These aspects are related to each other through concepts of Freud and Lacan to address the relation between drive and its object.(AU)

El presente artículo tiene por objetivo discutir, a partir de la película, Hoy quiero volver Solito del director brasileño Daniel Ribeiro, la manera como el Psicoanálisis piensa la sexualidad humana, enfrentándola siempre como una construcción. Para esa reflexión, se destacaran tres aspectos de la película: La homosexualidad del protagonista, su ceguera y sus pasos por la adolescencia. Estos aspectos serán relacionados entre sí mediante conceptos de Freud y Lacan que abordan la relación entre la pulsión sexual y su objetivo.(AU)

O intercâmbio impossível da adolescência: análise pscinalítica sobre o despertar da sexualidade por meio do filme "Hoje eu quero voltar sozinho" de Daniel Ribeiro / The impossible exchange of adolescence: a psychoanalytic analysis of the awakening of sexuality through the movie "The way he looks", by Daniel Ribeiro / El intercambio imposible de la adolescencia: análisis psicoanalítico del despertar de la sexualidad a través de la película "Hoy quiero volver solito" de Daniel Ribeiro

O presente artigo visa discutir, a partir do filme Hoje eu quero voltar sozinho, do diretor brasileiro Daniel Ribeiro, a maneira como a Psicanálise pensa a sexualidade humana, encarando-a sempre como uma construção. Para essa reflexão, serão destacados três aspectos do filme: o despertar para a homossexualidade do protagonista, sua cegueira e sua passagem pela adolescência. Esses aspectos serão relacionados entre si através de conceitos de Freud e Lacan que abordem a relação entre a pulsão sexual e seu objeto.

This paper discusses, from the movie The way he looks, by Brazilian director Daniel Ribeiro, the way psychoanalysis thinks human sexuality, always viewing it as a construction. For this reflection, three aspects of the film will be highlighted: the awakening of the protagonist's homosexuality, his blindness and his passage through adolescence. These aspects are related to each other through concepts of Freud and Lacan to address the relation between drive and its object.

El presente artículo tiene por objetivo discutir, a partir de la película, Hoy quiero volver Solito del director brasileño Daniel Ribeiro, la manera como el Psicoanálisis piensa la sexualidad humana, enfrentándola siempre como una construcción. Para esa reflexión, se destacaran tres aspectos de la película: La homosexualidad del protagonista, su ceguera y sus pasos por la adolescencia. Estos aspectos serán relacionados entre sí mediante conceptos de Freud y Lacan que abordan la relación entre la pulsión sexual y su objetivo.

Considerações psicanalíticas sobre os jogos de esconder: do puti ao esconde-esconde / Psychoanalytic considerations games to hide: the puti to hide and seek

A psicanálise muito tem discutido sobre a brincadeira infantil, mas pouco tem relacionado as descobertas sobre os jogos de esconder realizadas por Freud a partir de 1920 à teoria de que toda brincadeira representa o desejo de ser adulto. Por meio do estudo das brincadeiras de esconder, o presente trabalho visa revelar como a repetição encontra um lugar na teoria psicanalítica do brincar, tornando-se um operador mais importante do que o próprio desejo de ser adulto, tão caro ao olhar inicial de Freud para as atividades infantis...

Psychoanalytic considerations on hide-and-seek games: from Puti to Peekaboo. Psychoanalysis has much discussed children games, but has seldom related the discoveries about hiding and seeking games, carried by Freud in the 1920's, with the theory that all games represent the desire to be an adult. By studying the game of hide-and-seek, the present work aims at revealing how repetition finds its own place in the psychoanalytical theory of play and becomes a much more important operator than the desire a child holds of being an adult, as proposed by Freud...

Considerações psicanalíticas sobre os jogos de esconder: do puti ao esconde-esconde

A psicanálise muito tem discutido sobre a brincadeira infantil, mas pouco tem relacionado as descobertas sobre os jogos de esconder realizadas por Freud a partir de 1920 à teoria de que toda brincadeira representa o desejo de ser adulto. Por meio do estudo das brincadeiras de esconder, o presente trabalho visa revelar como a repetição encontra um lugar na teoria psicanalítica do brincar, tornando-se um operador mais importante do que o próprio desejo de ser adulto, tão caro ao olhar inicial de Freud para as atividades infantis(AU)

Psychoanalytic considerations on hide-and-seek games: from Puti to Peekaboo. Psychoanalysis has much discussed children games, but has seldom related the discoveries about hiding and seeking games, carried by Freud in the 1920's, with the theory that all games represent the desire to be an adult. By studying the game of hide-and-seek, the present work aims at revealing how repetition finds its own place in the psychoanalytical theory of play and becomes a much more important operator than the desire a child holds of being an adult, as proposed by Freud(AU)

Comparison of the osteogenic potential of mesenchymal stem cells from the bone marrow and adipose tissue of young dogs.

BACKGROUND: The aim of the present study was to compare the osteogenic potential of mesenchymal stem cells extracted from the bone marrow (BM-MSCs) and adipose tissue (AD-MSCs) of young dogs. The following parameters were assessed: dimethyl thiazolyl diphenyl tetrazolium (MTT) conversion, alkaline phosphatase (ALP) activity, collagen and mineralised matrix synthesis, and the expressions of osterix, bone sialoprotein (BSP), and osteocalcin (OC). RESULTS: MTT conversion was greater in BM-MSCs compared to AD-MSCs after 14 and 21 days of differentiation; ALP activity was greater in differentiated AD-MSCs on day 7; collagen synthesis was greater in BM-MSCs on days 14 and 21; the percentage of mineralized area per field was greater in BM-MSCs compared to AD-MSCs; osterix expression was greater in BM-MSCs in days 14 and 21, and BSP and OC expression levels were greater in BM-MSCs at all the investigation time-points. CONCLUSIONS: It was concluded that the osteogenic potential was greater in BM-MSCs than AD-MSCs when extracted from young dogs.