RESUMO
The synthesis of the new dye 1,6-methano[10]annulenecyanine is described. For this purpose, the 3,4-dicyano-1,6-methano[10]annulene and 3,4-carboxyimide-1,6-methano[10]annulene buildings blocks were synthesized in six to eight steps. In both cases, these building blocks were then cyclotetramerized to furnish a new Zn(II)-1,6-methano[10]annulenecyanine which presents a strong red-shifted absorption band at 800 nm and high solubility in common organic solvents.
Assuntos
Corantes Fluorescentes/síntese química , Compostos Organometálicos/síntese química , Corantes Fluorescentes/química , Estrutura Molecular , Compostos Organometálicos/química , SolubilidadeRESUMO
We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.
Assuntos
Automação/métodos , Produtos Biológicos/química , Desenho de Fármacos , Preparações Farmacêuticas/química , Tecnologia Farmacêutica/métodos , Produtos Biológicos/síntese química , Química Farmacêutica , Preparações Farmacêuticas/síntese químicaRESUMO
A suitable intermediate for the synthesis of eremophilanes and bakkanes was prepared by a highly regioselective and stereoselective one-step synthesis through a niobium catalyzed Diels-Alder reaction. As a demonstration of the versatility of this intermediate, a total synthesis of (+/-)-bakkenolide A is described.
