RESUMO
Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy. Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia.
Assuntos
Encéfalo/patologia , Transtornos Psicóticos/patologia , Esquizofrenia/patologia , Doença Aguda , Adulto , Brasil , Doença Crônica , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Masculino , Escalas de Graduação PsiquiátricaRESUMO
Em mulher de 45 anos, apresentando quadro de insuficiência cardíaca classe funcional III e dor torácica atípica, foi evidenciada dilataçäo importante da coronária direita e sua drenagem para o átrio direito, demostrada na ecocardiografia transtorácica e confirmada pela angiografia coronária. A paciente foi submetida a cirurgia, encontrando-se um ramo único desembocando no átrio direito, que foi ligado. Sua evoluçäo pós-operatória foi boa estando, há três anos, livre de qualquer sintomatologia.