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Acta Trop ; 182: 257-263, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29551394

RESUMO

Emerging and re-emerging viral infections transmitted by insect vectors (arthopode-borne viruses, arbovirus) are a serious threat to global public health. Among them, yellow fever (YFV), dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses are particularly important in tropical and subtropical regions. Although vector control is one of the most used prophylactic measures against arboviruses, it often faces obstacles, such as vector diversity, uncontrolled urbanization and increasing resistance to insecticides. In this context, vaccines may be the best control strategy for arboviral diseases. Here, we provide a general overview about licensed vaccines and the most advanced vaccine candidates against YFV, DENV, CHIKV and ZIKV. In particular, we highlight vaccine difficulties, the current status of the most advanced strategies and discuss how the molecular characteristics of each virus can influence the choice of the different vaccine formulations.


Assuntos
Arbovírus/imunologia , Vírus Chikungunya/imunologia , Vírus da Dengue/imunologia , Vacinas Virais/imunologia , Zika virus/imunologia , Animais , Febre de Chikungunya/prevenção & controle , Febre de Chikungunya/transmissão , Dengue/prevenção & controle , Dengue/transmissão , Vacinas contra Dengue/imunologia , Descoberta de Drogas , Humanos , Insetos Vetores/imunologia , Febre Amarela/prevenção & controle , Febre Amarela/transmissão , Vacina contra Febre Amarela/imunologia , Infecção por Zika virus/prevenção & controle , Infecção por Zika virus/transmissão
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