Effect of combined physical exercise on inflammatory markers and the relationship with body composition in young women.

OBJECTIVES: To evaluate the effect of eight weeks of combined physical exercise of moderate intensity on inflammatory markers, as well as its relationship with body composition in young women recently admitted to a Public Institution of Higher Education. METHODS: Longitudinal, intervention study, in which 59 female participants aged 18-25 years were evaluated before and after a combined physical exercise program for eight weeks. Blood samples were collected before and after the intervention for analysis of C-reactive protein and inflammatory cytokines. Weight and height were measured to calculate body mass index and body composition was evaluated by Dual Energy X-Ray Absorptiometry before and after the intervention. Statistical analyzes performed were t-test, Willcoxon test and Spearman's correlation. This study was approved by the Human Research Ethics Committee and the Free and Informed Consent Form was signed by all participants. RESULTS: After the intervention, there was a reduction in the pro-inflammatory cytokines (IL-1ß, IL-6, TNF and IL-12), while the anti-inflammatory (IL-10) and CRP did not change; reduction in the total body gynoid fat mass and in the percentage of body fat; increased trunk and total muscle mass. Body composition was negatively correlated with the pro-inflammatory interleukins IL-1ß and IL-6 and positively correlated with CRP. CONCLUSIONS: Combined physical exercise for eight weeks acted to reduce pro-inflammatory cytokines, fat mass and increase in muscle mass. Inflammatory markers correlated with body fat before the intervention, suggesting the participation of visceral adipose tissue in the release of these markers in female university students.

Physical activity and quality of life among college students without comorbidities for cardiometabolic diseases: systematic review and meta-analysis.

PURPOSE: To systematically review studies on the relationship between physical activity (PA) and quality of life (QOL) in university students without comorbidities for cardiometabolic diseases from around the world. METHODS: We included observational studies with university students of both sexes, from public or private institutions, and that investigated the association or correlation between physical activity and quality of life among these students, without delimitation of date, language, or location. Reviews, letters to the editors, studies with qualitative methodologies, case studies, book chapters, articles with college students who had some specific disease or condition, such as obesity, diabetes, and others; studies with children of parents with chronic diseases, and those that were institutions aimed only at very specific populations, were excluded. Meta-analysis was calculated. RESULTS: Thirty studies, consisting of 19,731 students, were included. The most commonly used instruments to assess the quality of life of the university population were the Quality of Life Questionnaire-short version (WHOQOL-BREF), and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). The International Physical Activity Questionnaire (IPAQ) was the most commonly used instrument to assess PA. For the meta-analysis, 22 studies were included. Weak but positive correlations were found between PA and the QOL domains: physical health (0.16. 95% CI 0.11 0.22; I2 = 99.96%); mental health (0.14; 95% CI 0.07-0.20; I2 = 99.97%); social relations (0.24, 95% CI 0.08-0. 38; I2 = 99.99%); environment (0.23, 95% CI 0.14-0.32; I2 = 99.90%); vitality (0.17. 95% CI 0.15-0.20; I2 = 99.49%) pain (0.02. 95% CI - 0.02 to 0.12; I2 = 99.96%); QOL and PA (0.21, 95% CI 0.08-0.34; I2 = 99.99%).An association of R = 0.60 (95% CI 0.25-0.95; I2 = 85.61%) was found between QOL and PA in total. CONCLUSION: The results of our study showed a weak but positive relationship between physical activity and overall quality of life in college students, and also between PA and the domains of QL: physical health, social relationships, mental health, environment, and vitality, in this same population. It is important to study this population, since risk behaviors in this phase tend to perpetuate in the other phases of life.

Lifestyle and vitamin D dosage in women with breast cancer.

INTRODUCTION: The prevention strategy of breast cancer is still the key factor for early diagnosis and the most effective method for tracking the disease. OBJECTIVE: This study aimed to evaluate the association vitamin D level with breast cancer in women. METHODS: This hospital case-control study was conducted with 181 women with breast cancer and 197 healthy controls. Vitamin D status, calcium, phosphorus and PTH serum dosage and data collection related to lifestyle and patient's history, besides anthropometric measurements were performed. Univariate analysis (Chi-square and raw odds ratio) and multivariate analysis were performed through multivariate logistic regression. RESULTS: This study shows a higher value of vitamin D in health controls (26.9 mg/dL) than in breast cancer women (24.8 mg/dL). Higher numbers of women with sufficient vitamin D status (34.85%) were found in control group than cancer group. Using the multiple logistic regression model, the family history of breast cancer (OR 36.37, 95%CI 4.75-278.50) and menopause (OR 5.17, 95% CI 2.72-9.80) had a direct association with breast cancer, while the level of vitamin D (OR 0.95, 95%CI 0.91-0.99) and moderate physical activity (OR 0.31, 95%CI 0.10-0.93) maintained the inverse associations with the disease. CONCLUSION: Vitamin D status and the practice of moderate physical activity were considered protective factors for breast cancer. However, menopause and family history of breast cancer were considered a risk factor for breast cancer.

Lifestyle and vitamin D dosage in women with breast cancer / Relación de la vitamina D y el ejercicio físico en mujeres con cáncer de mama

Introduction: The prevention strategy of breast cancer is still the key factor for early diagnosis and the most effective method for tracking the disease. Objective: This study aimed to evaluate the association vitamin D level with breast cancer in women. Methods: This hospital case-control study was conducted with 181 women with breast cancer and 197 healthy controls. Vitamin D status, calcium, phosphorus and PTH serum dosage and data collection related to lifestyle and patient’s history, besides anthropometric measurements were performed. Univariate analysis (Chi-square and raw odds ratio) and multivariate analysis were performed through multivariate logistic regression. Results: This study shows a higher value of vitamin D in health controls (26.9 mg/dL) than in breast cancer women (24.8 mg/dL). Higher numbers of women with sufficient vitamin D status (34.85%) were found in control group than cancer group. Using the multiple logistic regression model, the family history of breast cancer (OR 36.37, 95%CI 4.75-278.50) and menopause (OR 5.17, 95% CI 2.72-9.80) had a direct association with breast cancer, while the level of vitamin D (OR 0.95, 95%CI 0.91-0.99) and moderate physical activity (OR 0.31, 95%CI 0.10-0.93) maintained the inverse associations with the disease. Conclusion: Vitamin D status and the practice of moderate physical activity were considered protective factors for breast cancer. However, menopause and family history of breast cancer were considered a risk factor for breast cancer (AU)

Introducción: la estrategia de prevención del cáncer de mama sigue siendo el factor clave para el diagnóstico precoz y el método más eficaz para el seguimiento de la enfermedad. Objetivo: este estudio tuvo como objetivo evaluar el nivel de vitamina D asociado con el cáncer de mama en las mujeres. Métodos: este estudio de casos y controles hospitalarios se llevó a cabo con 181 mujeres con cáncer de mama y 197 controles sanas. Se estudió el nivel de vitamina D, calcio, fósforo y la dosis de suero PTH; se recopilaron de datos relacionados con el estilo de vida y con la historia de las pacientes, además se realizaron mediciones antropométricas. El análisis univariante (Chi-cuadrado probabilidades y primas ratio) y el análisis multivariado se realizó mediante regresión logística multivariante. Resultados: este estudio muestra un valor más alto de vitamina D en los controles de salud (26,9 mg/dl) que en las mujeres con cáncer de mama (24,8 mg/dl). Se encontraron más mujeres con suficiente vitamina D (34,85%) en el grupo control que en el grupo de cáncer. Usando el modelo de regresión logística múltiple, la historia familiar de cáncer de mama (OR 36,37; IC del 95%: 4,75 a 278,50) y la menopausia (OR 5,17; IC del 95%: 2,72 a 9,80) se halló una relación directa con el cáncer de mama, mientras que el nivel de vitamina D (OR 0,95; IC del 95%: 0,91 a 0,99) y la actividad física moderada (OR 0,31; IC del 95%: 0,10 a 0,93) mantienen las asociaciones inversas con la enfermedad. Conclusión: el estado de vitamina D y la práctica de actividad física moderada se consideraron factores de protección para el cáncer de mama. Sin embargo, la menopausia y la historia familiar de cáncer de mama se consideran un factor de riesgo para el cáncer de mama (AU)