RESUMO
Ketorolac 10 and 20 mg, ketoprofen 50 mg and placebo were compared in a multiple-dose, double-blind, randomized analgesic study that included 150 patients with pain after impacted third molar removal. Patients evaluated their study medication over a 48 h period. Bivariate and multivariate analysis revealed statistically significant differences between the different medications studied, evaluated by the consumption of rescue medication (50.4-80.4% of the placebo group required rescue versus 17.0-47.6% of the ketoprofen, 5.7-31.9% of the ketorolac 10 mg and 1.8-22.5% of the ketorolac 20 mg groups), the pain relief experienced by the patient (P<0.05), and the overall efficacy of the medication (P<0.05). The efficacy of ketorolac 10 mg did not differ from that of ketorolac 20 mg, and both were more efficacious than ketoprofen 50 mg, which in turn was more efficacious than the placebo. One-third of the placebo group did not require rescue medication. The factors with the greatest influence on the use of rescue medication were the analgesic taken by the patient and the presence or not of postoperative inflammation.
Assuntos
Anti-Inflamatórios não Esteroides/administração & dosagem , Cetoprofeno/administração & dosagem , Cetorolaco/administração & dosagem , Dente Serotino/cirurgia , Medição da Dor/efeitos dos fármacos , Dor Pós-Operatória/tratamento farmacológico , Administração Oral , Adolescente , Adulto , Análise de Variância , Distribuição de Qui-Quadrado , Método Duplo-Cego , Feminino , Humanos , Modelos Lineares , Modelos Logísticos , Masculino , Análise Multivariada , Efeito Placebo , PlacebosRESUMO
In myopia patients, Rh and acid phosphatase were typed in two groups: group 1 consisted of 214 patients with low myopia (-6 D or less); group 2 of 124 patients with high myopia (more than -6 D). Statistical analysis of the markers showed a good Hardy-Weinberg equilibrium for both groups. In the Rh system there was a significant difference between group 1 and the control population (p < 0.05), but not between group 2 and control (p > 0.1). In the case of ACP there was a significant difference between group 2 and the control population (p < 0.05), but not between group 1 and control (p > 0.25). We conclude that the observed association between myopia and Rh system (chromosome 1) involves low myopia, while the association between myopia and acid phosphatase (chromosome 2) involves high myopia. Further DNA research will lead to more specific results.
