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1.
Can J Neurol Sci ; : 1-9, 2023 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-37994530

RESUMO

INTRODUCTION: Despite the importance of timing of nerve surgery after peripheral nerve injury, optimal timing of intervention has not been clearly delineated. The goal of this study is to explore factors that may have a significant impact on clinical outcomes of severe peripheral nerve injury that requires reconstruction with nerve transfer or graft. MATERIALS AND METHODS: Adult patients who underwent peripheral nerve transfer or grafting in Alberta were reviewed. Clustered multivariable logistic regression analysis was used to examine the association of time to surgery, type of nerve repair, and patient characteristics on strength outcomes. Cox proportional hazard regression analysis model was used to examine factors correlated with increased time to surgery. RESULTS: Of the 163 patients identified, the median time to surgery was 212 days. For every week of delay, the adjusted odds of achieving Medical Research Council strength grade ≥ 3 decreases by 3%. An increase in preinjury comorbidities was associated with longer overall time to surgery (aHR 0.84, 95% CI 0.74-0.95). Referrals made by surgeons were associated with a shorter time to surgery compared to general practitioners (aHR 1.87, 95% CI 1.14-3.06). In patients treated with nerve transfer, the adjusted odds of achieving antigravity strength was 388% compared to nerve grafting; while the adjusted odds decreased by 65% if the injury sustained had a pre-ganglionic injury component. CONCLUSION: Mitigating delays in surgical intervention is crucial to optimizing outcomes. The nature of initial nerve injury and surgical reconstructive techniques are additional important factors that impact postoperative outcomes.

2.
Can J Neurol Sci ; : 1-5, 2023 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-37545347

RESUMO

INTRODUCTION: Traumatic spinal cord injuries (tSCI) are common, often leaving patients irreparably debilitated. Therefore, novel strategies such as nerve transfers (NT) are needed for mitigating secondary SCI damage and improving function. Although different tSCI NT options exist, little is known about the epidemiological and injury-related aspects of this patient population. Here, we report such characteristics to better identify and understand the number and types of tSCI individuals who may benefit from NTs. MATERIALS AND METHODS: Two peripheral nerve experts independently evaluated all adult tSCI individuals < 80 years old admitted with cervical tSCI (C1-T1) between 2005 and 2019 with documented tSCI severity using the ASIA Impairment Scale for suitability for NT (nerve donor with MRC strength ≥ 4/5 and recipient ≤ 2/5). Demographic, traumatic injury, and neurological injury variables were collected and analyzed. RESULTS: A total of 709 tSCI individuals were identified with 224 (32%) who met the selection criteria for participation based on their tSCI level (C1-T1). Of these, 108 (15% of all tSCIs and 48% of all cervical tSCIs) were deemed to be appropriate NT candidates. Due to recovery, 6 NT candidates initially deem appropriate no longer qualified by their last follow-up. Conversely, 19 individuals not initially considered appropriate then become eligible by their last follow-up. CONCLUSION: We found that a large proportion of individuals with cervical tSCI could potentially benefit from NTs. To our knowledge, this is the first study to detail the number of tSCI individuals that may qualify for NT from a large prospective database.

3.
Hand (N Y) ; 18(3): 385-392, 2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-34448408

RESUMO

BACKGROUND: Restoration of shoulder function in obstetrical brachial plexus injury is paramount. There remains debate as to the optimal method of upper trunk reconstruction. The purpose of this study was to test the hypothesis that spinal accessory nerve to suprascapular nerve transfer leads to improved shoulder external rotation relative to sural nerve grafting. METHODS: A systematic review of Medline, EMBASE, EBSCO CINAHL, SCOPUS, Cochrane Library, and TRIP Pro from inception was conducted. Our primary outcome was shoulder external rotation. RESULTS: Four studies were included. Nerve transfer was associated with greater shoulder external rotation relative to nerve grafting (mean difference: 0.82 AMS 95% confidence interval [CI]: 0.27-1.36, P < .005). Patients undergoing nerve grafting were more likely to undergo a secondary shoulder stabilizing procedure (odds ratio [OR]: 1.27, 95% CI: 0.8376-1.9268). CONCLUSION: In obstetrical brachial plexus injury, nerve transfer is associated with improved shoulder external rotation and a lower rate of secondary shoulder surgery. LEVEL OF EVIDENCE: Level III; Therapeutic.


Assuntos
Traumatismos do Nascimento , Neuropatias do Plexo Braquial , Plexo Braquial , Transferência de Nervo , Humanos , Ombro/cirurgia , Ombro/inervação , Transferência de Nervo/métodos , Neuropatias do Plexo Braquial/cirurgia , Estudos Retrospectivos , Plexo Braquial/lesões , Traumatismos do Nascimento/complicações , Traumatismos do Nascimento/cirurgia
4.
Neurosurgery ; 91(6): 856-862, 2022 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-36170167

RESUMO

BACKGROUND: Reverse end-to-side (RETS) nerve transfer has become increasingly popular in patients with severe high ulnar nerve injury, but the reported outcomes have been inconsistent. OBJECTIVE: To evaluate the "babysitting effect," we compared outcomes after anterior interosseous nerve RETS transfer with nerve decompression alone. To evaluate the source of regenerating axons, a group with end-to-end (ETE) transfer was used for comparisons. METHODS: Electrophysiology measures were used to quantify the regeneration of anterior interosseous nerve (AIN) and ulnar nerve fibers while functional recovery was evaluated using key pinch and Semmes-Weinstein monofilaments. The subjects were followed postsurgically for 3 years. RESULTS: Sixty-two subjects (RETS = 25, ETE = 16, and decompression = 21) from 4 centers in Western Canada were enrolled. All subjects with severe ulnar nerve injury had nerve compression at the elbow except 10 in the ETE group had nerve laceration or traction injury. Postsurgically, no reinnervation from the AIN to the abductor digiti minimi muscles was seen in any of the RETS subjects. Although there was no significant improvement in compound muscle action potentials amplitudes and pressure detection thresholds in the decompression and RETS group, key pinch strength significantly improved in the RETS group ( P < .05). CONCLUSION: The results from published clinical trials are conflicting in part because crossover regeneration from the donor nerve has never been measured. Unlike those with ETE nerve transfers, we found that there was no crossover regeneration in the RETS group. The extent of reinnervation was also no different from decompression surgery alone. Based on these findings, the justifications for this surgical technique need to be carefully re-evaluated.


Assuntos
Transferência de Nervo , Nervo Ulnar , Humanos , Nervo Ulnar/cirurgia , Transferência de Nervo/métodos , Estudos de Coortes , Estudos Prospectivos , Canadá
5.
Clin Neurol Neurosurg ; 216: 107217, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35339861

RESUMO

OBJECTIVE: To assess the case volume and self-perceived competence of current mandatory skills in peripheral nerve surgery. DESIGN: Cross sectional survey based study examining case volume and self-reported competence in peripheral nerve surgery. SETTING: Canadian Neurosurgery and Plastic Surgery accredited residency programs PARTICIPANTS: All Canadian Neurosurgery and Plastic Surgery senior trainees (PGY 3+) invited to participate RESULTS: Much variability exists in both exposure to cases and perceived senior resident competence for both plastic and neurosurgery residents. Confidence in surgical ability as perceived competency is lower in trainees for more advanced peripheral nerve procedures. Self- reported confidence increased with post-graduate experience. CONCLUSIONS: Overall, the findings in this study highlight the importance of increasing operative experience in complex peripheral nerve surgery among surgical residents.

6.
JBJS Case Connect ; 11(2)2021 05 13.
Artigo em Inglês | MEDLINE | ID: mdl-33983907

RESUMO

CASE: The reconstruction of large nerve gaps remains a reconstructive challenge. Here, we present a case report of brachial plexus reconstruction using nerve grafts harvested as spare parts from an amputated limb. It also allowed us to use motor nerve grafts to reconstruct defects in the posterior cord and musculocutaneous nerve. The patient recovered good shoulder and elbow function at 2.5 years with evidence of innervation distally on electromyography. CONCLUSION: Spare part surgery should always be kept in a surgeons' reconstructive algorithm. Reconstruction of large nerve gaps can be achieved with autologous nerve grafts in certain circumstances.


Assuntos
Neuropatias do Plexo Braquial , Plexo Braquial , Transferência de Nervo , Plexo Braquial/cirurgia , Neuropatias do Plexo Braquial/etiologia , Cotovelo , Humanos , Transferência de Nervo/efeitos adversos , Procedimentos Neurocirúrgicos/efeitos adversos
7.
Plast Reconstr Surg ; 147(5): 1202-1207, 2021 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-33835089

RESUMO

BACKGROUND: Although there was initial success using tibial nerve transfer to restore ankle dorsiflexion following peroneal nerve injury, results from later series were less promising. A potential reason is coactivation of the much stronger antagonistic muscles during gait. The purpose of this study was to test the hypothesis that gait training would improve functional performance following tibial nerve transfer. METHODS: Using a prospective, nonrandomized, controlled study design, patients were divided into two groups: surgery only or surgery plus gait training. Of the 20 patients who showed reinnervation in the tibialis anterior muscle, 10 were assigned to the gait training group, and an equal number were in the control group. Those in the treatment group began training once reinnervation in the tibialis anterior muscle was detected, whereas those in the control group continued to use their ankle-foot orthosis full time. Differences in ankle dorsiflexion were measured using the Medical Research Council scale, and quantitative force measurement and functional disability was measured using the Stanmore Scale. RESULTS: Patients in the gait training group attained significantly better functional recovery as measured by the Stanmore Scale (79.5 ± 14.3) (mean ± SD) versus (37.2 ± 3.5) in the control group (p = 0.02). Medical Research Council grades were 3.8 ± 0.6 in the training group versus 2.5 ± 1.2 in the surgery only group (p < 0.05). Average dorsiflexion force from patients with above antigravity strength (all from the training group) was 31 percent of the contralateral side. CONCLUSION: In patients with successful reinnervation following tibial nerve transfers, rehabilitation training significantly improved dorsiflexion strength and function. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.


Assuntos
Marcha , Transferência de Nervo/reabilitação , Nervo Fibular/lesões , Nervo Fibular/cirurgia , Nervo Tibial/cirurgia , Adulto , Feminino , Humanos , Masculino , Transferência de Nervo/métodos , Ensaios Clínicos Controlados não Aleatórios como Assunto , Estudos Prospectivos , Recuperação de Função Fisiológica , Resultado do Tratamento , Adulto Jovem
9.
Neurorehabil Neural Repair ; 34(4): 299-308, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32089098

RESUMO

Background. Autologous nerve graft is the most common clinical intervention for repairing a nerve gap. However, its regenerative capacity is decreased in part because, unlike a primary repair, the regenerating axons must traverse 2 repair sites. Means to promote nerve regeneration across a graft are needed. Postoperative electrical stimulation (PES) improves nerve growth by reducing staggered regeneration at the coaptation site whereas conditioning electrical stimulation (CES) accelerates axon extension. In this study, we directly compared these electrical stimulation paradigms in a model of nerve autograft repair. Methods. To lay the foundation for clinical translation, regeneration and reinnervation outcomes of CES and PES in a 5-mm nerve autograft model were compared. Sprague-Dawley rats were divided into: (a) CES, (b) PES, and (c) no stimulation cohorts. CES was delivered 1 week prior to nerve cut/coaptation, and PES was delivered immediately following coaptation. Length of nerve regeneration (n = 6/cohort), and behavioral testing (n = 16/cohort) were performed at 14 days and 6 to 14 weeks post-coaptation, respectively. Results. CES treated axons extended 5.9 ± 0.2 mm, significantly longer than PES (3.8 ± 0.2 mm), or no stimulation (2.5 ± 0.2 mm) (P < .01). Compared with PES animals, the CES animals had significantly improved sensory recovery (von Frey filament testing, intraepidermal nerve fiber reinnervation) (P < .001) and motor reinnervation (horizontal ladder, gait analysis, nerve conduction studies, neuromuscular junction analysis) (P < .01). Conclusion. CES resulted in faster regeneration through the nerve graft and improved sensorimotor recovery compared to all other cohorts. It is a promising treatment to improve outcomes in patients undergoing nerve autograft repair.


Assuntos
Axônios/fisiologia , Estimulação Elétrica , Regeneração Nervosa/fisiologia , Cuidados Pós-Operatórios , Cuidados Pré-Operatórios , Recuperação de Função Fisiológica/fisiologia , Nervo Tibial/fisiologia , Nervo Tibial/transplante , Animais , Comportamento Animal/fisiologia , Modelos Animais de Doenças , Estimulação Elétrica/métodos , Extremidade Inferior , Masculino , Atividade Motora/fisiologia , Condução Nervosa/fisiologia , Ratos , Ratos Sprague-Dawley , Método Simples-Cego , Transplante Autólogo
10.
Neurosurgery ; 86(6): 769-777, 2020 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-31432080

RESUMO

BACKGROUND: Patients with severe cubital tunnel syndrome often have poor functional recovery with conventional surgical treatment. Postsurgical electrical stimulation (PES) has been shown to enhance axonal regeneration in animal and human studies. OBJECTIVE: To determine if PES following surgery for severe cubital tunnel syndrome would result in better outcomes compared to surgery alone. METHODS: Patients with severe cubital tunnel syndrome in this randomized, double-blind, placebo-controlled trial were randomized in a 1:2 ratio to the control or stimulation groups. Control patients received cubital tunnel surgery and sham stimulation, whereas patients in the stimulation group received 1-h of 20 Hz PES following surgery. Patients were assessed by a blinded evaluator annually for 3 yr. The primary outcome was motor unit number estimation (MUNE) and secondary outcomes were grip and key pinch strength and McGowan grade and compound muscle action potential. RESULTS: A total of 31 patients were enrolled: 11 received surgery alone and 20 received surgery and PES. Three years following surgery, MUNE was significantly higher in the PES group (176 ± 23, mean + SE) compared to controls (88 ± 11, P < .05). The mean gain in key pinch strength in the PES group was almost 3 times greater than in the controls (P < .05). Similarly, other functional and physiological outcomes showed significantly greater improvements in the PES group. CONCLUSION: PES enhanced muscle reinnervation and functional recovery following surgery for severe cubital tunnel syndrome. It may be a clinically useful adjunct to surgery for severe ulnar neuropathy, in which functional recovery with conventional treatment is often suboptimal.


Assuntos
Síndrome do Túnel Ulnar/cirurgia , Descompressão Cirúrgica/métodos , Terapia por Estimulação Elétrica/métodos , Cuidados Pós-Operatórios/métodos , Recuperação de Função Fisiológica/fisiologia , Índice de Gravidade de Doença , Adulto , Idoso , Síndrome do Túnel Ulnar/diagnóstico , Síndrome do Túnel Ulnar/fisiopatologia , Método Duplo-Cego , Eletromiografia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Condução Nervosa/fisiologia , Resultado do Tratamento , Nervo Ulnar/fisiologia , Nervo Ulnar/cirurgia
11.
Plast Surg (Oakv) ; 27(3): 223-229, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31453142

RESUMO

BACKGROUND: In order to increase one's competitiveness in the current job market, Canadian plastic surgery graduates may complete additional degrees and multiple fellowships. The authors sought to determine the impact of this additional training on the practice profile of recent graduates and determine the current state of job satisfaction among this group. METHODS: An anonymous cross-sectional online survey was created and sent to all 250 graduates of Canadian plastic surgery residencies from 2005 to 2015. Demographics were collected and questions grouped into clinical, teaching, research, and administrative components. Questions pertaining to job satisfaction were also included. RESULTS: The response rate to the survey was 39%. Sixty-nine (71%) respondents had permanent attending positions at the time of survey completion, while the remaining 28 respondents did not. Among those with permanent positions, 59 (86%) completed at least one fellowship and 30 (43%) have an advanced degree. Of those who did fellowship training, 76% practice primarily in their area of subspecialty. Having an advanced degree showed a trend to a higher percentage of practice dedicated to research (5.6% vs 1.9%; P = .074) and more publications per year were seen among this group (1.31 vs 0.30; P = .028). Eighty-six percent of respondents are satisfied with their current attending position. CONCLUSIONS: The majority of recent Canadian plastic surgery graduates are undergoing fellowship training and are practicing primarily in their fields of subspecialty training. Having a postgraduate degree was associated with a higher number of publications per year as an attending surgeon. Job satisfaction is high among recent graduates.


HISTORIQUE: Afin d'accroître leur compétitivité sur le marché du travail, les diplômés canadiens en chirurgie plastique peuvent obtenir d'autres diplômes et de multiples postdoctorats. Les auteurs ont cherché à établir les retombées de cette formation supplémentaire sur le profil de pratique des récents diplômés ainsi que la satisfaction au travail des membres de ce groupe. MÉTHODOLOGIE: Les 250 diplômés d'une résidence en chirurgie plastique au Canada entre 2005 et 2015 ont reçu un sondage transversal anonyme en ligne. Les chercheurs ont recueilli les données démographiques et ont regroupé les questions dans les volets de la clinique, de l'enseignement, de la recherche et de l'administration. Il y avait également des questions sur la satisfaction au travail. RÉSULTATS: Le taux de réponse au sondage s'élevait à 39 %. Soixante-neuf répondants (71 %) occupaient un poste permanent au moment du sondage, contrairement aux 28 autres. Chez ceux qui occupaient un poste permanent, 59 (86 %) avaient effectué au moins un postdoctorat et 30 (43 %) possédaient un diplôme avancé. Parmi ceux qui avaient fait un postdoctorat, 76 % exerçaient surtout dans leur domaine de surspécialité. Un diplôme avancé s'associait à une tendance vers un pourcentage plus élevé de pratiques vouées à la recherche (5.6 % par rapport à 1.9 %; P = .074), qui suscitaient plus de publications annuelles (1.31 par rapport à 0.30; P = .028). Quatre-vingt-six pour cent des répondants étaient satisfaits de leur poste. CONCLUSIONS: La majorité des récents diplômés en chirurgie plastique au Canada étudient au postdoctorat et exercent surtout dans leur domaine de surspécialité. Le postdoctorat s'associait à un plus grand nombre de publications par année de la part des chirurgiens. La satisfaction au travail était élevée chez les récents diplômés.

13.
Plast Reconstr Surg ; 143(1): 111e-120e, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30589790

RESUMO

BACKGROUND: Carpal tunnel syndrome is very common. Although surgery is effective in mild and moderate cases, recovery is often incomplete in severe cases. Therefore, adjuvant therapy to improve nerve regeneration in those patients is much needed. Acetyl-L-carnitine has been shown to be effective in other neuropathies. The goal of this study is to test the hypothesis that acetyl-L-carnitine can promote nerve regeneration and improve function in patients with severe carpal tunnel syndrome. METHODS: In this proof-of-principle, double-blind, randomized, placebo-controlled trial, adults with severe carpal tunnel syndrome were randomized to receive 3000 mg/day of acetyl-L-carnitine orally or placebo following carpal tunnel release surgery for 2 months. Outcomes were assessed at baseline and at 3, 6, and 12 months postoperatively. Symptom severity and functional outcomes were assessed using the Boston Carpal Tunnel Questionnaire and a wide range of physiologic and functional outcome measures. Patient safety was monitored by physical examination, blood work, and serum drug levels. The outcomes were analyzed using repeated measure two-way analysis of variance. RESULTS: Twenty patients with similar baseline characteristics were assigned randomly to the treatment or placebo group in a 1:1 ratio. Sixty percent were women with a mean age ± SD of 59 ± 2. The treatment was safe with no major adverse events reported. Although patients in both groups showed improvements postoperatively, there was no significant difference in any of the outcome measures between the groups. CONCLUSION: Although acetyl-L-carnitine was well tolerated, it did not improve nerve regeneration or functional recovery in patients with severe carpal tunnel syndrome. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.


Assuntos
Acetilcarnitina/uso terapêutico , Síndrome do Túnel Carpal/tratamento farmacológico , Síndrome do Túnel Carpal/cirurgia , Descompressão Cirúrgica/métodos , Regeneração Nervosa/efeitos dos fármacos , Adulto , Síndrome do Túnel Carpal/diagnóstico , Método Duplo-Cego , Eletromiografia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Regeneração Nervosa/fisiologia , Condução Nervosa , Prognóstico , Curva ROC , Valores de Referência , Medição de Risco , Índice de Gravidade de Doença , Resultado do Tratamento
14.
J Craniomaxillofac Surg ; 46(5): 875-882, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29628301

RESUMO

Facial reanimation provides patients affected by chronic facial paralysis a chance to regain basic human functions such as emotional expression, verbal communication, and oral competence for eating and swallowing, but there is still no consensus as to the best way to measure surgical outcomes. We performed a literature review to investigate the different functional outcomes that surgeons use to evaluate facial function after reanimation surgery, focusing on outcomes other than facial expressions such as speech, oral competence, and patient quality of life/satisfaction. A total of 37 articles were reviewed, with the majority reporting outcomes through subjective facial expression ratings and only 15 dealing with other functional outcomes. In particular, outcomes related to oral competence and speech were reported inconsistently. Facial reanimation patients would benefit from a unified movement to create and validate through consensus, an outcomes reporting system incorporating not only facial expression, but also oral competence, speech, and patient-reported quality of life, to enable global patient assessment.


Assuntos
Músculos Faciais/cirurgia , Paralisia Facial/cirurgia , Procedimentos de Cirurgia Plástica , Humanos , Procedimentos de Cirurgia Plástica/métodos , Resultado do Tratamento
15.
J Otolaryngol Head Neck Surg ; 47(1): 7, 2018 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-29361981

RESUMO

BACKGROUND: Shoulder dysfunction is common after neck dissection for head and neck cancer (HNC). Brief electrical stimulation (BES) is a novel technique that has been shown to enhance neuronal regeneration after nerve injury by modulating the brain-derived neurotrophic growth factor (BDNF) pathways. The objective of this study was to evaluate the effect of BES on postoperative shoulder function following oncologic neck dissection. METHODS: Adult participants with a new diagnosis of HNC undergoing Level IIb +/- V neck dissection were recruited. Those in the treatment group received intraoperative BES applied to the spinal accessory nerve (SAN) after completion of neck dissection for 60 min of continuous 20 Hz stimulation at 3-5 V of 0.1 msec balanced biphasic pulses, while those in the control group received no stimulation (NS). The primary outcome measured was the Constant-Murley Shoulder (CMS) Score, comparing changes from baseline to 12 months post-neck dissection. Secondary outcomes included the change in the Neck Dissection Impairment Index (ΔNDII) score and the change in compound muscle action potential amplitude (ΔCMAP) over the same period. RESULTS: Fifty-four patients were randomized to the treatment or control group with a 1:1 allocation scheme. No differences in demographics, tumor characteristics, or neck dissection types were found between groups. Significantly lower ΔCMS scores were observed in the BES group at 12 months, indicating better preservation of shoulder function (p = 0.007). Only four in the BES group compared to 17 patients in the NS groups saw decreases greater than the minimally important clinical difference (MICD) of the CMS (p = 0.023). However, NDII scores (p = 0.089) and CMAP amplitudes (p = 0.067) between the groups did not reach statistical significance at 12 months. BES participants with Level IIb + V neck dissections had significantly better ΔCMS and ΔCMAP scores at 12 months (p = 0.048 and p = 0.025, respectively). CONCLUSIONS: Application of BES to the SAN may help reduce impaired shoulder function in patients undergoing oncologic neck dissection, and may be considered a viable adjunct to functional rehabilitation therapies. TRIAL REGISTRATION: Clinicaltrials.gov ( NCT02268344 , October 17, 2014).


Assuntos
Traumatismos do Nervo Acessório/prevenção & controle , Estimulação Elétrica/métodos , Neoplasias de Cabeça e Pescoço/cirurgia , Esvaziamento Cervical/efeitos adversos , Articulação do Ombro/fisiopatologia , Traumatismos do Nervo Acessório/etiologia , Adulto , Idoso , Canadá , Método Duplo-Cego , Feminino , Seguimentos , Neoplasias de Cabeça e Pescoço/mortalidade , Neoplasias de Cabeça e Pescoço/parasitologia , Humanos , Cuidados Intraoperatórios/métodos , Masculino , Pessoa de Meia-Idade , Esvaziamento Cervical/métodos , Amplitude de Movimento Articular/fisiologia , Medição de Risco , Resultado do Tratamento
17.
Plast Reconstr Surg ; 140(4): 747-756, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28609352

RESUMO

BACKGROUND: Upper trunk obstetric brachial plexus injury can cause profound shoulder and elbow dysfunction. Although neuroma excision with interpositional sural nerve grafting is the current gold standard, distal nerve transfers have a number of potential advantages. The goal of this study was to compare the clinical outcomes and health care costs between nerve grafting and distal nerve transfers in children with upper trunk obstetric brachial plexus injury. METHODS: In this prospective cohort study, children who underwent triple nerve transfers were followed with the Active Movement Scale for 2 years. Their outcomes were compared to those of children who underwent nerve graft reconstruction. To assess health care use, a cost analysis was also performed. RESULTS: Twelve patients who underwent nerve grafting were compared to 14 patients who underwent triple nerve transfers. Both groups had similar baseline characteristics and showed improved shoulder and elbow function following surgery. However, the nerve transfer group displayed significantly greater improvement in shoulder external rotation and forearm supination 2 years after surgery (p < 0.05). The operative time and length of hospital stay were significantly lower (p < 0.05), and the overall cost was approximately 50 percent less in the nerve transfer group. CONCLUSION: Triple nerve transfer for upper trunk obstetric brachial plexus injury is a feasible option, with better functional shoulder external rotation and forearm supination, faster recovery, and lower cost compared with traditional nerve graft reconstruction. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.


Assuntos
Traumatismos do Nascimento/cirurgia , Neuropatias do Plexo Braquial/cirurgia , Plexo Braquial/lesões , Transferência de Nervo/métodos , Procedimentos de Cirurgia Plástica/métodos , Nervo Sural/transplante , Tronco/inervação , Plexo Braquial/cirurgia , Feminino , Seguimentos , Humanos , Lactente , Masculino , Estudos Prospectivos , Recuperação de Função Fisiológica/fisiologia , Resultado do Tratamento
18.
Trials ; 17: 200, 2016 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-27079660

RESUMO

BACKGROUND: Carpal tunnel syndrome (CTS) is the most common form of peripheral nerve injury, affecting approximately 3 % of the population. While surgery is effective in mild and moderate cases, nerve and functional recovery are often not complete in severe cases. Therefore, there is a need for adjuvant methods to improve nerve regeneration in those cases. Acetyl-L-carnitine (ALCAR) is involved in lipid transport, vital for mitochondrial function. Although it has been shown to be effective in various forms of neuropathies, it has not been used in traumatic or compressive peripheral nerve injury. METHODS: In this pilot study we will utilize a double-blind, randomized, placebo-controlled design. Inclusion criteria will include adult patients with severe CTS. This will be confirmed by nerve conduction studies and motor unit number estimation (MUNE). Only those with severe motor unit loss in the thenar muscles (2 standard deviations [SD] below the mean for the age group) will be included. Eligible patients will be randomized to receive 3,000 mg/day of ALCAR orally or placebo following carpal tunnel release surgery for 2 months. The primary outcome will be MUNE with supplementary secondary outcome measures that include: 1) two-point discrimination; 2) Semmes-Weinstein monofilaments for pressure sensitivity; 3) cold and pain threshold for small fiber function; 4) Boston self-assessment Carpal Tunnel Questionnaire and 5) Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire for symptom severity; and 6) Purdue Pegboard Test for hand functional performance. To follow post treatment recovery and monitor safety, patients will be seen at 3 months, 6 months and 1 year. The outcome measures will be analyzed using two-way ANOVA, with treatment assignment and time points being the independent factors. If significant associations are detected, a post hoc analysis will be completed. We aim to recruit ten patients into each of the two groups. Data from this pilot will provide the basis for power calculation for a full-scale trial. DISCUSSION: ALCAR is a physiologic peptide crucial for fatty acid transport. ALCAR has been shown to be effective in neuroprotection in the central nervous system and increase peripheral nerve regeneration. This has been applied clinically to various systemic peripheral neuropathies including diabetic neuropathy, antiretroviral toxic neuropathy, and chemotherapy-induced peripheral neuropathy. While animal evidence exists for the benefit of ALCAR in compression neuropathy, there have been no human studies to date. This trial will represent the first use of ALCAR in peripheral nerve injury/compression neuropathy. TRIAL REGISTRATION: NCT02141035 ; 20 April 2015.


Assuntos
Acetilcarnitina/uso terapêutico , Síndrome do Túnel Carpal/tratamento farmacológico , Regeneração Nervosa/efeitos dos fármacos , Acetilcarnitina/efeitos adversos , Alberta , Síndrome do Túnel Carpal/diagnóstico , Síndrome do Túnel Carpal/fisiopatologia , Síndrome do Túnel Carpal/cirurgia , Protocolos Clínicos , Terapia Combinada , Avaliação da Deficiência , Método Duplo-Cego , Humanos , Exame Neurológico , Procedimentos Ortopédicos , Medição da Dor , Projetos Piloto , Recuperação de Função Fisiológica , Projetos de Pesquisa , Índice de Gravidade de Doença , Inquéritos e Questionários , Fatores de Tempo , Resultado do Tratamento
19.
J Hand Surg Am ; 41(7): e211-5, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27113908

RESUMO

Reconstruction of the suprascapular nerve (SSN) after brachial plexus injury often involves nerve grafting or a nerve transfer. To restore shoulder abduction and external rotation, a branch of the spinal accessory nerve is commonly transferred to the SSN. To allow reinnervation of the SSN, any potential compression points should be released to prevent a possible double crush syndrome. For that reason, the authors perform a release of the superior transverse scapular ligament at the suprascapular notch in all patients undergoing reconstruction of the upper trunk of the brachial plexus. Performing the release through a standard anterior open supraclavicular approach to the brachial plexus avoids the need for an additional posterior incision or arthroscopic procedure.


Assuntos
Plexo Braquial/cirurgia , Descompressão Cirúrgica/métodos , Ligamentos Articulares/cirurgia , Síndromes de Compressão Nervosa/prevenção & controle , Síndromes de Compressão Nervosa/cirurgia , Ombro/cirurgia , Plexo Braquial/lesões , Humanos , Cuidados Pós-Operatórios
20.
Knee Surg Sports Traumatol Arthrosc ; 23(10): 3044-8, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25957609

RESUMO

Knee dislocation with a common peroneal nerve injury is a serious problem. A case of multi-ligamentous knee injury with the unusual and interesting finding of a common peroneal nerve rupture incarcerated within the knee joint is presented. MRI and arthroscopic images are used to document this occurrence. To date, there are no published reports of a similar finding in the English orthopaedic literature. Level of evidence IV.


Assuntos
Luxação do Joelho/complicações , Traumatismos do Joelho/complicações , Traumatismos dos Nervos Periféricos/complicações , Nervo Fibular/lesões , Neuropatias Fibulares/etiologia , Adulto , Humanos , Luxação do Joelho/diagnóstico , Luxação do Joelho/cirurgia , Traumatismos do Joelho/diagnóstico , Traumatismos do Joelho/cirurgia , Imageamento por Ressonância Magnética , Masculino , Procedimentos Neurocirúrgicos/métodos , Procedimentos Ortopédicos/métodos , Traumatismos dos Nervos Periféricos/diagnóstico , Traumatismos dos Nervos Periféricos/cirurgia , Neuropatias Fibulares/diagnóstico , Neuropatias Fibulares/cirurgia , Ruptura
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