Predictive Value of Clinical and Magnetic Resonance Image Findings in the Diagnosis of Meniscal and Anterior Cruciate Ligament Injuries.

BACKGROUND: Anterior Cruciate Ligament (ACL) injuries may be accompanied by associated injuries such as meniscal injuries. Clinical evaluation alone may at times miss the diagnosis of ACL injury and one or more associated injuries. However, an adjuvant diagnostic tool such as an MRI of the knee may be unaffordable to some patients. The goal of this study was to compare the sensitivity, specificity and predictive value of clinical and magnetic resonance image (MRI) findings in the diagnosis of anterior cruciate ligament and meniscal injuries. METHODS: This was a prospective study. The cases of ACL injury recruited had a magnetic resonance imaging of the injured knee, and knee arthroscopy done. The clinical, magnetic resonance imaging and arthroscopic diagnostic findings were all noted. The sensitivity, specificity, positive predictive value and negative predictive values of clinical and MRI findings were compared, with arthroscopic findings as gold standard. RESULTS: A total of seventy-seven patients were recruited for the study. There were fifty-four males and twenty three females. The results of the tests of the sensitivity, specificity, positive predictive value and negative predictive value of clinical diagnosis and MRI when compared with arthroscopy findings, in detecting meniscal and anterior cruciate ligament injuries were as follows: For Clinical evaluation; Anterior Cruciate ligament: 81%, 80%, 86% and 76%; Medial Meniscus: 84%, 77%, 84% and 93%; and Lateral Meniscus: 85%, 77%, 85% and 82% respectively. For MRI: Anterior Cruciate Ligament (ACL): 87%, 89%, 93% and 78% ; Medial Meniscus: 87% 79%, 70% and 82%; and the Lateral Meniscus: 70%, 76% 73% and 72%. CONCLUSION: The specificity, sensitivity and predictive value of clinical and MRI findings were comparable in relation to the diagnosis of ACL and Medial Meniscus tears. However, the values of these parameters were better with clinical examination than with MRI in relation to the diagnosis of lateral meniscus tears.

Obesity and response to neoadjuvant chemotherapy in breast cancer

The prevalence of obesity is rising worldwide including Sub-Saharan Africa just as the incidence of breast cancer is rising in same region with increasing morbidity and mortality. Obesity or overweight has been identified as a risk factor for breast cancer and both have been associated with poor outcome of breast cancer treatment. The objective of this study was to assess the effect of obesity /overweight on clinical response to Adriamycin Cyclophosphamide-Paclitaxel (AC-P) regimen neoadjuvant chemotherapy in patients with breast cancer. A prospective observational of 39 female patients with breast cancer. A prospective observational study of newly diagnosed breast cancer patients with palpable breast lumps on neoadjuvant chemotherapy of AC-P regime. Age of the patients, tumour size, stage, estrogen, progestogen and HER2 receptor status were noted. Height measured in metres and weight measured in Kilograms were recorded and Body Mass Index (BMI) calculated .Tumour size measured at presentation, then after first, third, sixth and eighth doses to determine response as defined by the UICC method such as complete clinical response, partial clinical response, stable disease and progressive disease. BMI was then categorized into Normal weight 25kg/m2 and Overweight 25-30kg/m2 and Obese 30kg/m2. 43.6% were obese, 33.3% were overweight and 23.1% were normal weight. Thirty percent of overweight /obese patients had complete clinical response 2 compared with 77% of low/normal weight patients and this was statistically significant (X2 =6.53, p 0.015). 76.7% of the overweight/obese were premenopausal compared with 23.3% who were post menopausal, and this is statistically significant.(X2 =5.84, p 0.024). Obesity/ overweight is associated with poorer clinical response to neoadjuvant chemotherapy in the cohort of patients studied

Ultrasound prevalence and characteristics of incidental thyroid lesions in Nigerian adults.

AIM/OBJECTIVE: Thyroid lesions are common and range from the incidental, asymptomatic, small solitary nodule to the large and partly intrathoracic masses. Thyroid lesions that are not palpable but identified by radiological imaging for unrelated symptoms are defined as incidentalomas of the thyroid gland. OBJECTIVE: The aim of this study was to determine the ultrasound prevalence of thyroid incidentalomas and describe the ultrasound characteristics of such detected incidentalomas in Nigerian adults. METHODS: This was a prospective study that examined 340 subjects over a period of 6 months. They were selected randomly from volunteers and patients presenting for ultrasound examination of other parts of the body. The subjects had their necks examined by palpation and ultrasound in the department of Radiology, University College Hospital, Ibadan, using a General Electric LogicP5 ultrasound machine with a 6-10 MHz linear transducer. Any incidentaloma detected was classified using the 'Thyroid Imaging Reporting and Data System' (TIRADS) classification. RESULTS: Three hundred and forty (340) subjects comprising of 153 males and 187 females were examined. The ultrasound prevalence of thyroid incidentalomas was 22.4%. Thyroid incidentalomas were more common in females than males but this was not statistically significant. The prevalence of thyroid incidentaloma significantly increased with age up to the seventh decade. Majority of the lesions were solitary, homogenous and cystic. CONCLUSION: The ultrasound prevalence of thyroid incidentalomas documented in the study area is high (22.4%) and they were commoner in women and older subjects. Majority of the lesions, 41 (53.95%) were classified as TIRADS 2 (benign lesions).