Synthesis of new xanthenone derivatives of expected antibilharzial activity.

A new series of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles incorporated directly and/or indirectly into a xanthenone moiety at position-2 were synthesized. Some of the newly prepared compounds were biologically tested as schistosomicides in experimental animals.

Synthesis of 1-(heterocyclic substituted anilino)-9H-thioxanthon-9-ones and their antitumor activity.

Some new 9H-thioxanthen-9-one incorporated into heterocyclic systems such as pyridone8, pyrazoline9, pyranone11, iminopyrane12, furopyrimidine17, imidazothiazole19, thiazole21, triazine24 and other related compounds through a para imminophenyl grouping at position-1 of the thioxanthenone ring were synthesized and tested as antitumor agents, against L 1210 leukemia in mice. Some of the new compounds showed considerable antitumor activity.