RESUMO
The article contains experimental data on the morphofunctional state of gonads in male rats after chronic inhalation of diamine P, and on the state of embryogenesis after inhalant introduction of diamine P into pregnant rats in threshold-level concentrations. Results of the study revealed that, in chronic inhalant introduction at 29.3 and 4.2 mg/m3, diamine P demonstrated gonadotoxic properties, which was proved by the higher percentage of dead spermatozoa and spermatogonium diseases. The changes in the gonads' state reflected the pathological processes caused by diamine P in the animals due to the general toxicity properties of the substance. The embryotoxic effect of diamine P in inhalations at 5 mg/m3 (close to the threshold levels of total toxicity) was not statistically relevant.
Assuntos
Antiespermatogênicos/toxicidade , Modelos Biológicos , Éteres Fenílicos/toxicidade , Resorcinóis/toxicidade , Espermatogênese/efeitos dos fármacos , Espermatozoides/efeitos dos fármacos , Administração por Inalação , Animais , Antiespermatogênicos/administração & dosagem , Depressão Química , Masculino , Éteres Fenílicos/administração & dosagem , Ratos , Resorcinóis/administração & dosagem , Contagem de Espermatozoides/efeitos dos fármacos , Espermatogênese/fisiologiaRESUMO
Perinatal pathology may become the cause of diseases in children and adults. Cardiovascular system of the foetus and placental vessels are examined in the toxicosis of the pregnancy, hypertension of pregnant mothers, immunological system and sex glands in large foetus, thyroid and sex glands of newborns. It is suggested that early atherosclerosis, myocardiopathy, sexual disturbances, endocrinopathy, immunodeficient states are consequences of pathological or "prepathological" development of certain organs and systems of the foetus.
Assuntos
Doenças Fetais/patologia , Doenças do Recém-Nascido/epidemiologia , Animais , Sistema Cardiovascular/patologia , Feminino , Macrossomia Fetal/patologia , Feto/patologia , Gônadas/patologia , Humanos , Hipertensão/patologia , Sistema Imunitário/patologia , Recém-Nascido , Doenças do Recém-Nascido/etiologia , Placenta/patologia , Pré-Eclâmpsia/patologia , Gravidez , Ratos , Ratos Endogâmicos , Fatores de Risco , Estações do Ano , Glândula Tireoide/patologiaRESUMO
The biological action of deep freezing (-196 degrees C) on the ovary with the purpose of establishing the possibility of using low temperatures for long-term storage of this tissue was studied. The use of polyethylene oxide of molecular weight 400 at an optimal concentration (20%) for freezing at a rate of 1 degree per minute to -8 degrees C, then 10 degrees/min to --196 degrees C permits to retain the functional activity of the ovary and restoration of its function after transplantation.
