1.
Org Lett
; 25(49): 8952-8956, 2023 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38055630
RESUMO
An asymmetric synthesis via an axially chiral arylaryne intermediate was developed. A cycloaddition reaction with various arynophiles was used to obtain chiral biaryl compounds while preserving the enantiomeric excess (ee) of a precursor even though the reaction proceeds through an arylaryne intermediate, whose ee decreases on a time-dependent basis. High chiral transfer from a precursor to a product was observed not only at low temperature (-78 °C) but also at room temperature.