[Post-transfusion hepatitis]. / Aspecte ale hepatitei posttransfuzionale (HPT).

The incidence, aetiology, evolution, prognosis and treatment of PTH was studied in 253 cases selected from among 7224 patients with acute viral hepatitis, admitted to hospital during the 1973-1979 period. Following the rational application of transfusion and elimination of hepatitis virus B carriers, there was a three-fold decrease in the frequency of PTH. Control of the donors by contra-immunoelectrophoresis showed that PTH type B represents at least 26.8% of the total number of PTH. In order to eliminate PTH type B a more sensitive technique should be used in order to detect HBs Ag in the donors. The treatment being complex and hospitalization prolonged, the cost of PTH patients is greater than that of acute viral hepatitis patients, in general, justifying the additional expenses required for the prevention of PTH.

[Incidence of antibodies against hepatitis virus A (anti-HA) in a non-selected urban population]. / Frecventa anticorpilor fata de virusul hepatitei A (anti-HA) într-o populatie urbana neselectata.

Anti-HA antibodies were determined by radioimmunoassay according to the HAVAB-ABBOTT technique in 244 subjects, of whom 194 without hepatic involvement, 25 with non B hva and 25 former non B hva patients. Anti-HA anti-bodies were found in 67% of the healthy subjects and 100% of the patients and former hva cases. The incidence of anti-HA antibodies increases with age being in 30% of children and 83.5% of adults. A peak incidence was found between the ages 21 and 30 years. In the district investigated subclinical infection with HVA was frequent, beginning in childhood and up to the age of 30 years. The qualitative HAVAB test is adequate for epidemiological investigations; a quantitative variant is necessary for the diagnosis.

[Frequency and prognostic value of the "e" system in hepatitis B virus infection]. / Frecventa si valoarea prognostica a sistemului "e" în infectia cu virusul hepatic B.

The frequency and prognostic value of the "e" system was determined in acute and chronic hepatitis patients and in blood donors by immunodiffusion on Abott rheophoresis plates. The incidence of HBe Ag in acute viral hepatitis was 20% at the beginning of the disease; its persistance indicated a prolonged evolution and a tendency to a chronic course. The presence of anti-HBe at the beginning of the acute disease may indicate the onset of a non-B hepatitis in an HBe carrier. In chronic hepatitis the incidence of HBe Ag was 58% and in blood donors only 6%. Anti-HBe was absent in chronic hepatitis and present in 15% of blood donors.

[Diagnostic and prognostic value of antialbumin antibodies (AAA) in acute viral hepatitis]. / Valoarea diagnostica si prognostica a anticorpilor antialbumina (A.A.A.) în hepatita virala acuta.

The behaviour of antialbumin antibodies (AAA) was tested by immunodiffusion in 284 patients suffering from acute viral hepatitis. AAA were found in more than 80% of the cases, and in only 16% of the control lot. The AAA titer was higher the more severe was the clinical form of the disease. As the AAA titer appears to be a marker of functional alterations of the hepatocyte, the test might be used to check the recovery of convalescents after acute viral hepatitis.

[Incidence and duration of blood HBs antigen in convalescents after type B viral hepatitis]. / Antigenemia HBs ca frecventa si durata la convalescentii de hepatita virala tip B.

The presence of HBs Ag was determined by contraelectrophoresis in 500 convalescents after hepatitis B, at the moment of discharge and after 1--3 and 6 months. Antigen carriage is prolonged in hepatitis B, 51% of the convalescents being positive on discharge and 10% remaining persistent carriers. This was more frequent in males, young adults and those who had suffered from mild, prolonged forms of the disease. As only 42% of the patients became negative within the first 20 days of hospitalization it became necessary to prolong their stay in hospital and to follow up the patients subsequently in an out-patient unit.

[The disseminated intravascular coagulation syndrome and infection]. / Sindromul de coagulare intravasculara diseminata si infectia

The disseminated intravascular coagulation syndrome (1) Definition. History. (2) Etiopathogeny of the disseminated intravascular coagulation syndrome. (3) The clinical and laboratory diagnosis of the disseminated intravascular coagulation syndrome. (4) The principal infections in which the disseminated intravascular coagulation syndrome has been described: bacterial, viral, rickettsial, parasitic, mycotic. (5) Treatment of the disseminated intravascular coagulation syndrome.