Emergency department presentation of children with tuberculosis.

OBJECTIVES: The objectives were to describe emergency department (ED) presentations of children with tuberculosis (TB) disease and assess the utility in children of TB screening tools developed for adults. METHODS: Children at most 18 years old with confirmed or probable TB seen at the Children's TB Clinic from 2005 to 2009 who were initially evaluated in the ED for symptoms compatible with TB in the preceding month were included. TB was classified as microbiologically confirmed disease or probable TB disease, as defined by the World Health Organization. RESULTS: Sixty children (29 with confirmed TB and 31 with probable TB) were identified after presentation to the ED, representing 35% of all children diagnosed with TB at the two hospitals during this interval. Eighty-eight percent were previously healthy. Fifty-five percent were Hispanic, 30% were black or African American, 12% were Asian, and 3% were white. Forty-four (73%) had intrathoracic disease (37 pulmonary parenchymal or pleural disease, four miliary disease, two endobronchial, one pericarditis). Sixteen (27%) had extrathoracic disease (eight meningitis, five cervical lymphadenopathy, two gastrointestinal, one interstitial keratitis), 11 of whom also had abnormal chest radiographs, including all eight children with TB meningitis. Most (76.7%) were diagnosed at the time of their first ED visit or during their first hospital admission, 12% after their second ED visit, 10% after their third ED visit, and one patient after six ED visits to various facilities. In 33 case (55%), the diagnosis was suspected in the ED because of epidemiologic risk factors (15), radiographic evaluation (11), or symptoms (7). Hemoptysis (12%) and night sweats (10%) were uncommon. Neither cavitary lesions (seen in two children) nor apical lesions (seen in 42%) predominated. The five screening tools validated for adults with pulmonary disease were 77% to 98% sensitive in identifying children with intrathoracic TB and 50% to 100% sensitive for extrathoracic TB. CONCLUSIONS: The point of entry to health care for many children with TB is the ED. The more protean manifestations of TB in children can decrease the utility of screening tools developed to identify adults with TB. While TB in adults often is a microbiologic diagnosis, childhood TB often is an epidemiologic diagnosis. Therefore, questioning caregivers about TB risk factors in the family may identify a higher percentage of children with possible TB.

Mycobacterial infections in Texas children: a 5-year case series.

The epidemiology of nontuberculous mycobacterial infections is poorly understood, particularly in regions where tuberculosis (TB) is endemic. In 5 years, 75 children had nontuberculous mycobacterial disease (30 lymphadenopathy, 17 pulmonary, 17 soft tissue, and 11 bacteremia) and 30 had TB. Divergent antibiotic susceptibility profiles and the persistence of disease caused by TB emphasize the importance of microbiologic diagnosis for suspected mycobacterial disease.

Childhood pleural tuberculosis: a review of 45 cases.

BACKGROUND: Pleural tuberculosis (TB) can be seen in isolation or complicate untreated pulmonary disease in children. It is infrequently suspected in low incidence countries, leading to delays in diagnosis and treatment. METHODS: This was a retrospective descriptive case series of children

Tuberculosis among adult visitors of children with suspected tuberculosis and employees at a children's hospital.

OBJECTIVE: Few children with tuberculosis (TB) have communicable disease, and most do not require isolation within the hospital. However, parents or adult visitors with unrecognized pulmonary TB may be a threat to hospital staff and other patients. We prospectively evaluated adults accompanying children hospitalized for suspected TB at a children's hospital to determine the frequency of undiagnosed, potentially contagious disease. METHODS: From 1992 to 1998, chest radiographs were obtained from adult caretakers accompanying 59 consecutive children admitted to Texas Children's Hospital with suspected TB. A child and his or her family were placed under Airborne Precautions only if the child or the accompanying adult exhibited characteristics of potentially contagious disease. Annual rates of tuberculin skin test conversion in hospital employees were obtained for the same period. RESULTS: Of the 105 screened adults, 16 (15%) had previously undetected pulmonary TB. These adults were associated with 14 (24%) of the 59 children. In all instances in which the adult was the patient's parent, he or she was the source of infection to the child. Only 8 (13.5%) of the 59 children required isolation. Tuberculin skin test conversion from a negative to a positive reaction occurred in 127 employees (8 per 1,000 employee-years at risk). Only 4 of these 127 employees performed activities involving direct patient contact. None was in contact with families with a known potentially contagious adult or pediatric patient. CONCLUSIONS: The risk of infection of healthcare workers from pediatric patients with primary TB appeared to be minimal, and most children with TB did not need isolation. Infection control efforts should be focused on accompanying adults and adult visitors.

Treatment of childhood tuberculosis with a six month directly observed regimen of only two weeks of daily therapy.

BACKGROUND: Recommended treatment of childhood tuberculosis is 6 months in duration with at least 3 drugs. We studied a regimen requiring as few as 58 doses, given entirely by directly observed therapy (DOT), under program conditions. METHODS: An observational trial was conducted to determine the effectiveness of a completely DOT 6-month regimen for pulmonary, pleural and lymph node tuberculosis in children with the use of 2 weeks of daily isoniazid, rifampin and pyrazinamide therapy; then 6 weeks of twice weekly isoniazid, rifampin and pyrazinamide therapy; followed by 16 weeks of twice weekly isoniazid and rifampin. All therapy was given by workers from the health department, and patients were followed by the Children's Tuberculosis Clinic in Houston, TX. Patients were evaluated for changes in symptoms, weight, clinical or radiographic findings and adherence to therapy. RESULTS: Of the 175 evaluable children (159 pulmonary/thoracic node, 4 pleural, 12 cervical lymph node), 81% of children completed treatment in 6 months. Of the 33 patients who received extended treatment, 3 did so because of physician choice, 17 had an inadequate response to initial therapy, 2 had significant adverse reactions to drugs and 16 had poor adherence to the DOT. Only 37% of patients had complete resolution of disease at the end of treatment, but all continued to improve after therapy was stopped. There was only 1 patient who relapsed after 4 years. CONCLUSION: This regimen had results comparable with those of 6-month regimens with longer durations of daily therapy. Determining treatment response in pediatric tuberculosis is difficult because of the slow resolution of chest radiograph abnormalities. DOT is an important aspect of treatment but does not solve all problems with treatment adherence.