Case of Orbital Mucosa-Associated Lymphoid Tissue Lymphoma Associated with Serous Retinal Detachment.

We present a case of orbital mucosa-associated lymphoid tissue (MALT) lymphoma accompanied by a serous retinal detachment (SRD). A 44-year-old man who developed uveitis accompanied by a SRD in the right eye was referred to the Chiba National Hospital. B-mode ultrasonography and magnetic resonance imaging (MRI) showed a thickened choroidal membrane and a retrobulbar mass. Although topical steroid treatments improved the inflammation, the SRD did not improve. He was then referred to the Chiba University Hospital. Two months later, the retrobulbar mass had increased, and a partial resection biopsy combined with flow cytometry was performed. The final diagnosis was MALT lymphoma. After R-CHOP (rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy, signs of the tumour could not be detected and the SRD was reduced. We conclude that the SRD was most likely due to the infiltration of lymphoma cells and also to choroidal circulatory disturbances. Retrobulbar malignant lymphomas associated with a SRD are very rare and difficult to diagnosis without biopsy, but because early diagnosis is helpful in deciding the appropriate therapy, we recommend partial biopsy.

Foveal microstructure on spectral-domain optical coherence tomographic images and visual function after macular hole surgery.

PURPOSE: To determine the correlation between the recovery of foveal microstructure and the visual acuity or the foveal sensitivity after idiopathic macular hole (MH) closure. DESIGN: Prospective, consecutive, observational case series. METHODS: We studied 43 eyes of 43 patients before and 1, 3, and 6 months after MH surgery. The best-corrected visual acuity (BCVA), the foveal sensitivity measured by MP1 microperimetry, and the photoreceptor inner and outer segment (IS/OS) junction and the external limiting membrane (ELM) determined by spectral-domain optical coherence tomography were investigated. RESULTS: Preoperatively, the lengths of the IS/OS junction defect and the ELM defect were significantly correlated with only the foveal sensitivity (P<.0001). At all postoperative times, the lengths of both the IS/OS and ELM defects were significantly correlated with both the BCVA and the foveal sensitivity (P<.05 for all). The preoperative lengths of both the IS/OS and ELM defects were significantly correlated with the foveal sensitivity at 6 months after surgery (P=.0022, P=.0031, respectively). The IS/OS junction defect was significantly correlated with the ELM defect at all times (P<.0001 for all). No restoration of the IS/OS junction was observed in eyes without the ELM restoration. CONCLUSIONS: The restoration of the ELM is closely associated with that of the IS/OS junction. The preoperative IS/OS or ELM defect was associated with the postoperative foveal sensitivity. The restoration of not only the IS/OS junction but also the ELM may reflect the morphologic and functional recovery of the foveal photoreceptors in surgically closed MHs.