The Changes in the 18F FDG Metabolism in the Muscles by the Use of Cuboid Support Insoles.

Healthy men aged 55,39, 23.45 years were administered 18F-fluorodeoxyglucose (18F-FDG) after fasting for over 5 h; then, a 30-min self-paced walking (6-min walk and 2-min rest + 6-min walk and 2-min rest + 6-min walk and 2-min rest + 6-min walk) session was performed. While walking, the same athletic shoes were used, same with walking supports, flat insoles, and cuboid support insoles (BMZ Inc., Tokyo, Japan). The walking test was performed with eye open. The examination was performed over 30 days apart. 18F-FDG accumulation within the gastrocnemius muscle was higher, the walking speed was improved. These results suggest that the use of cuboid support insoles may improve the cadence of the lower leg muscles.

Introduction of Induction Heating is too late for older residents with difficulty in handling fire.

Handling errors with household flammables, for example pan burning, may result in serious accidents, which may be caused by decreased attention or executive function. Objective: The manuals by several cities simply suggest the use of induction heating (IH) cookers. However, it requires complicated operation of buttons. Furthermore, no previous studies have examined the difficulty of IH operation in older adults. Methods: We examined 166 residents aged 75+ years in Wakuya, consisting 66 Clinical Dementia Rating (CDR) 0 (healthy), 79 CDR 0.5 (very mild dementia), and 21 CDR 1+ (dementia) participants. Based on fire accident, they were classified into "high-risk," "low-risk," and "safety" groups. They were asked to actually use an IH as an examination. The participants who passed all procedures were classified as "good users," and the remaining who failed were classified as "poor users." Their overall cognitive and executive functions were assessed using the Mini-Mental State Examination (MMSE) and Trail Making Test A and Digit Symbol (DS), respectively. Results: The proportions of "good users" in the CDR 0, CDR 0.5, and CDR 1+ groups were 7 (10.6%), 6 (7.3%), and 0 (0%), respectively. For the CDR 0 and CDR 0.5 group, the good users had higher scores on the MMSE and DS than do the poor users. Conclusions: The introduction of IH is too late for "high-risk group." Since the IH cooker requires complicated operation of buttons, they may be difficult for older residents to handle. Executive function may be examined for early detection of handling errors with household flammables.

Erros no manuseio de artigos domésticos muito aquecidos, por exemplo, panelas, podem resultar em acidentes graves, que podem ser causados por diminuição da atenção ou de funções executivas. Objetivo: Manuais de várias cidades sugerem simplesmente o uso de fogões de aquecimento por indução (FAI), mas esses aparelhos requerem uma operação complexa, com necessidade de uso de diversos botões. No entanto, nenhum estudo anterior examinou a dificuldade de operação de FAI em adultos mais velhos. Métodos: Foram examinados 166 residentes de Wakuya, Japão, com mais de 75 anos, entre os quais 66 participantes com classificação clínica de demência (CDR) 0 (saudável), 79 CDR 0,5 (demência muito leve) e 21 CDR 1+ (demência). Em função do risco de queimadura, eles foram classificados nos grupos "alto," "baixo risco" e "sem risco". Solicitou-se que realmente utilizassem o FAI como parte do exame. Os participantes que passaram em todos os procedimentos foram classificados como "bons usuários", enquanto os demais foram classificados como "usuários fracos". As funções cognitivas e executivas globais foram avaliadas por meio do Miniexame do Estado Mental (MEEM), do Teste de Trilha A e do Teste Dígito-Símbolo (DS), respectivamente. Resultados: As proporções de "bons usuários" nos grupos CDR 0, CDR 0,5 e CDR 1+ foram 7 (10,6%), 6 (7,3%) e 0 (0%), respectivamente. Para os grupos CDR 0 e CDR 0,5, os "bons usuários" tiveram pontuações mais altas no MEEM e no DS em comparação com os "usuários fracos". Conclusões: A introdução de FAI é muito tardia para o grupo de "alto risco". Uma vez que o FAI requer uma operação complicada com o uso de botões, o seu manuseio pode ser difícil para os residentes mais velhos. A função executiva pode ser examinada para a detecção precoce de erros de manuseio de aparelhos domésticos que podem causar acidentes.

Decreased Time on the Nondominant One-Leg Standing Test Associated with Repeated Falls in Older Residents with Healthy Aging, Mild Cognitive Impairment, and Dementia: The Wakuya Project.

INTRODUCTION: The aim of this study is to clarify the association between repeated falls and the dominant/nondominant side in the open-eyed one-leg standing (OLS) test among people who are healthy or have mild cognitive impairment (MCI) or dementia in a community setting. We recruited 180 participants from 39 areas in the town of Wakuya. METHODS: This is a cross-sectional study. Participants were classified into 3 Clinical Dementia Rating (CDR) groups, i.e., CDR 0 (healthy, n = 71), CDR 0.5 (MCI, n = 85), and CDR 1+ (n = 23), and they were investigated for motor function (grip strength, 6-m normal gait speed, timed up and go test, and OLS test) and falls during the past year. RESULTS: Subjects with a CDR of 0.5 had higher rates of single and repeated falls (13.0 and 23.4%, respectively) than the CDR 0 group (12.1 and 4.5%, respectively), as did those in CDR 1+ group (15.0 and 30.0%). For the CDR 0.5 group, the frequency of falls was negatively (biologically meaningful direction) correlated with the left OLS time. No significant correlations with falls were found for other motor function tests. Another analysis separating the CDR 0.5 group into 2 subgroups (repeated falls vs. no or a single fall) also showed that the left OLS time was lower in subjects with repeated falls. CONCLUSION: People with MCI who had fallen repeatedly in the year before the assessment had a significantly lower left OLS time compared to those who had not fallen or had had 1 fall with MCI. None of the other physical measures were associated with past repeat falls including OLS on the dominant right side. No such findings were noted in the CDR 0 and CDR 0+ groups.

Word Processing Is Faster than Picture Processing in Alzheimer's Disease.

OBJECTIVE: Alzheimer's disease (AD) is characterized by a slow progressive impairment of episodic memory. Many studies have shown that AD exhibits deterioration of semantic memory during the course of disease progression. We previously reported that AD patients exhibited severe access disorders in the semantic memory system, using the Momentary Presentation Task (20 or 300 ms). In this study, we studied access disorder in patients with AD by the use of object difference (pictures vs words) methods. METHODS: 56 patients with probable AD (NINCDS-ADRDA, mean age 79.0 years) and 11 healthy controls (HC) (mean age 67.0 years) were studied. Ten pictures and 10 corresponding Japanese Hiragana words were presented arbitrarily for 20 and 300 ms on the monitor screen which were correctly named at the usual confrontation setting (i.e., semantic memory preserved). They were asked to name the pictures or to read the words or nonsense syllables aloud. RESULTS: The AD group showed significantly lower scores than the HC group, especially for the 20 ms condition. For the type of stimuli, the AD patients had better performances for words > pictures > nonsense syllables, although no differences for the HC group. The effect of AD severity was noted, moderate > severe stage. CONCLUSIONS: Our results suggested that the processing speed in AD patients may have reduced, even if the semantic memory were preserved. These data indicated that the difference in the processing speeds by the type of stimuli (pictures, words, and nonsense syllables) may be a character of AD patients.

Disturbed social recognition and impaired risk judgement in older residents with mild cognitive impairment after the Great East Japan Earthquake of 2011: the Tome Project.

AIM: After the Great East Japan Earthquake of 2011, we investigated the safety of residents in the affected communities. Most of the people requiring help were elderly and had previously been assessed as Clinical Dementia Rating (CDR) 0.5 (i.e. as having mild cognitive impairment (MCI)). We examined how well they understood the television news and whether they could make appropriate decisions. METHODS: This community-based study of dementia and difficulties following a disaster started in Tome, northern Japan. The subjects were 188 randomly selected older residents who underwent CDR, blood tests, magnetic resonance imaging, and cognitive tests, including an original visual risk cognition task. They were shown NHK news broadcasts from the day of the earthquake to determine whether they could understand the content. RESULTS: Neither the CDR 0 (healthy) nor the CDR 0.5 (MCI) subjects fully understood the television news. Some subjects did not recognize the danger of aftershocks and engaged in risky behaviour. CDR 0.5 subjects who exhibited such behaviour scored lower on the visual risk cognition task. CONCLUSIONS: It is noteworthy that television news is difficult to understand, even for healthy older adults. We found that MCI subjects had particular difficulties due to the disaster and suggest that risk cognition could be evaluated using visually presented materials.

Necker cube copying may not be appropriate as an examination of dementia: reanalysis from the Tajiri Project.

BACKGROUND: The Necker cube is usually used for evaluating the visuoconstructional ability of patients with mild cognitive impairment (MCI) and dementia. However, the Necker cube is often considered a drawing with a visual illusionary perspective. The purpose of this study was to investigate whether Necker cube copying could detect participants with MCI due to dementia. METHODS: We retrospectively analyzed the database of the 1998 prevalence study that was part of the Tajiri Project (n = 599). Pencil drawings of the Necker cube on A4-sized white paper by non-demented people (Clinical Dementia Rating (CDR) 0 and 0.5, n = 256) were classified into two patterns: non-three-dimension (3-D) and 3-D. Two neuropsychologists assessed Necker cube copying according to the criteria of the classification. After the classification, the database of the 2003 incidence study was used according to the subjects' conversion to dementia. RESULTS: In the prevalence study, among those who made a non-3-D drawing of the Necker cube, there were significantly fewer people in the CDR 0 group than in the CDR 0.5 and CDR 1+ groups; similarly, there were significantly fewer people in the CDR 0.5 group than in the CDR 1 + group (χ(2) = 32.6, P < 0.001; post-hoc tests using χ(2) tests, CDR 0 > CDR 0.5 > CDR 1+, P < 0.001). In the incidence study, among those who made a non-3-D drawing of the Necker cube, there were significantly fewer people in the non-converter group than in the converter group (χ(2) = 19.9, P < 0.001). However, there was no significant difference between the non-converter group (n = 21) and the converter group (n = 21) when age, sex, educational levels, and Mini-Mental State Examination scores were controlled (χ(2) = 0.0, P = 1.000). CONCLUSIONS: Our results suggested that Necker cube copying may evaluate visual illusion as well as visuoconstructional ability. The Necker cube may not be an appropriate test to detect participants with MCI due to dementia.