Assuntos
Colangite/diagnóstico , Infecções por Citomegalovirus/complicações , Síndrome de Job/complicações , Pancreatite/diagnóstico , Doença Aguda , Adulto , Antivirais/uso terapêutico , Colangite/tratamento farmacológico , Colangite/etiologia , Infecções por Citomegalovirus/tratamento farmacológico , Ganciclovir/uso terapêutico , Humanos , Masculino , Pancreatite/tratamento farmacológico , Pancreatite/etiologia , Resultado do TratamentoRESUMO
A 50-year-old man with chronic HCV infection had been received the injections of 12MU of Consensus-Interferon (C-IFN) three times a week in a previous hospital. Six months later, C-IFN therapy was terminated because of fever and massive ascites. Diuretics and antibiotics had not been effective against these symptoms. In the meantime, skin symptoms of purpura and giant ulcers in the extremities developed, and he was transferred to our hospital. Because skin biopsy revealed vasculitis and serum MPO-ANCA was positive, the diagnosis of ANCA associated vasculitis was made. Methylpredonizoron pulse therapy improved skin symptoms and massive ascites, and the skin ulcers eventually disappeared. ANCA is suggested to be responsible for this rare complication.
Assuntos
Anticorpos Anticitoplasma de Neutrófilos , Hepatite C Crônica/tratamento farmacológico , Interferon Tipo I/efeitos adversos , Vasculite/etiologia , Anticorpos Anticitoplasma de Neutrófilos/sangue , Humanos , Interferon Tipo I/administração & dosagem , Interferon-alfa , Masculino , Metilprednisolona/administração & dosagem , Pessoa de Meia-Idade , Peroxidase/imunologia , Pulsoterapia , Proteínas Recombinantes , Resultado do Tratamento , Vasculite/diagnóstico , Vasculite/tratamento farmacológicoRESUMO
RATIONALE AND OBJECTIVE: This study was to measure localized ground-glass attenuation (GGA) in the peripheral lung on thin-section computed tomography (CT) and to assess any relationship between the attenuation and lesion. MATERIALS AND METHODS: Twenty-eight surgically resected tumors with localized GGA at thin-section CT were studied. The tumors were histologically diagnosed as 8 atypical adenomatous hyperplasia (AAH), 11 bronchioloalveolar carcinoma (BAC), and 9 BAC with fibrosis. We assumed three concentric circles, which were 0.8, 1.0, and 1.2 times the diameter of each tumor and measured the average CT values corresponding to inside each circle. We calculated a difference in CT value between 0.8 and 1.2 times the diameter of the tumor and defined as the contrast index. RESULTS: The contrast index for tumors with AAH, BAC, and BAC with fibrosis were 19.8 +/- 8.3, 42.5 +/- 16.0 (P < 0.05 vs. group with AAH), and 111.4 +/- 32.6 (P < 0.0001 vs. Group with BAC), respectively. The contrast index became greater in the stepwise progression from AAH to BAC and from BAC to BAC with fibrosis. CONCLUSION: The contrast index correlated histologic findings of the tumor growth in BAC. The contrast index may be a useful and objective measurement for determining surgical treatment for localized GGA in preoperative diagnosis.
