[Oxidative stress in mechanism of psychosomatic disorders realization in duodenal ulcer in students].

AIM: To study the role of oxidative stress in mechanism of psychosomatic disorders involvement in pathogenesis of ulcerogenesis. MATERIAL AND METHODS: Psychosomatic disorders (PSD) and oxidative stress (OS) were assessed in 120 students with duodenal ulcer (DU) who had no concomitant pathology. Examination for PSD included interviewing by questionnaires. OS was judged by the level of lipid peroxidation products (malonic dialdehyde and dienic conjugates) and antioxidant activity--by glutathion peroxidase and superoxidedismutase. Melatonin was measured by enzyme immunoassay. RESULTS: A close correlation was discovered between the severity and features of PSD, lowering of melatonin, severity of OS and clinical features of the disease. CONCLUSION: DU students develop PSD which become leading factors of ulcerogenesis. One of the mechanisms of their participation in ulcerogenesis may be related with lowering of melatonin which is a potent stress regulator and corrector of lipid peroxidation and antioxidant activity.

[Endothelial dysfunction in pathogenesis of duodenal ulcer]. / Endotelial'naia disfunktsiia v patogeneze iazvennoi bolezni dvenadtsatiperstnoi kishki.

It is shown that in patients with ulcer associated with Helicobacter pylori (HP) there is a close correlation between the severity of the lesion of gastroduodenal protective mucous barrier and that of endothelial dysfunction manifesting in elevated level of endothelin-1, serum levels of TBK-active products, inhibition of blood flow and narrowing of the celiac trunk. The correlation becomes stronger with expanding contamination of gastroduodenal mucosa with HP. Thus, HP may participate in breaking the protective mucous barrier in endothelial dysfunction.

[Various rhythmologic precursors of terminal arrhythmia in patients with myocardial infarct]. / Nekotorye ritmologicheskie predvestniki terminal'nykh aritmii u bol'nykh infarktom miokarda.

The presence of near one hour ultradian cardiac rhythm was revealed on the ECG of 24 patients with acute myocardial infarction during 24-hour Holter monitoring. A classification of the phases of near one hour rhythm was developed according to the first coefficient value of autocorrelation of cardiac rhythm function. Special attention was attracted to the critical phase indicating high probability of the development of terminal arrhythmia and the threatening phase preceding it. Peculiarities of the variational structure of cardiac rhythm in the threatening phase and physical prerequisites of its origination are discussed.