Block of gonadotropic activity with a long-acting estroprogestogen.

PIP: 40 healthy, fertile women received an intramuscular injection of F1 6902 (100 mg of MAP-depot + 20 mg of estradiol valerianate) on Day 5 of menstrual cycle. Urinary luteinizing hormone (LH) determinations were made throughout the cycle. At both the 13th and 23rd day, in treated patients, the urinary LH diminished significantly (F .01) with respect to Day 5 of cycle. Patient age and LH value on Day 5 correlated (P .05) insignificantly. However, a negative correlation between age and the difference between LH on Day 5 and 13 was found (P .05); i.e., the lower the subject age, the greater the reduction in LH value. No significant variations in cervical pH were observed either at Day 13 or 23 with respect to Day 5 values. Of the 40 subjects treated, 25 had quantitatively regular menstrual flow from the 23rd-26th day after administration. Of the remaining 15, 2 had anticipated flows, 5 had spotting, and the remaining 8 had delayed menstruation. 3 spotting subjects were curettaged and the endometrium was atrophic with a stromal component of a decidual type prevailing on the glandular type.^ieng