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1.
J Am Vet Med Assoc ; 254(3): 393-398, 2019 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-30668237

RESUMO

CASE DESCRIPTION A 13-year-old neutered male Abyssinian cat with a 4-month history of right forelimb edema and multifocal crusting lesions at the distal aspect of the antebrachium was referred to a veterinary teaching hospital for evaluation. Extensive hemorrhage from the lesions had been observed after self-grooming, and findings on histologic examination of a skin biopsy sample prior to referral were consistent with atypical dermal hemodynamics and inflammation. CLINICAL FINDINGS Diffuse pitting edema and multifocal, 3- to 4-mm-diameter sanguineous crusting lesions affecting the antebrachium were observed distal to a pulsatile subcutaneous mass in the right elbow joint region that had a palpable thrill and auscultable bruit. No systemic abnormalities were detected. TREATMENT AND OUTCOME Contrast-enhanced CT angiography with 3-D reconstruction identified an arteriovenous fistula with a large aberrant vessel coursing distally. Surgical ligation of an arterialized vein distal to the fistula without en bloc resection led to resolution of all clinical signs. The vascular anomaly was no longer patent when diagnostic imaging was repeated 5 months after surgery. CLINICAL RELEVANCE Acquired arteriovenous fistulas can lead to bleeding skin lesions affecting the antebrachium in cats. Surgical ligation of an aberrant reverse-shunting vein distal to the fistula successfully resolved clinical signs in the cat of this report and may warrant investigation as a treatment option in cats with this condition.


Assuntos
Fístula Arteriovenosa/veterinária , Doenças do Gato , Antebraço , Animais , Gatos , Ligadura/veterinária , Masculino
2.
J Vet Diagn Invest ; 30(2): 324-328, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29284382

RESUMO

Bowenoid in situ carcinomas (BISCs) are papillomavirus (PV)-induced skin neoplasms that are thought to be caused by Felis catus papillomavirus (FcaPV) 2. As BISCs are typically multiple and can become extensive, they can be difficult to treat. Herein we describe 4 cats that developed skin neoplasms that contained FcaPV-3 DNA. One cat developed multiple basal cell carcinomas (BCCs), 1 a BISC with unusual extension into hair follicles, and 2 developed a single typical-appearing BISC. All neoplasms contained prominent PV-induced cell changes and intense p16CDKN2a protein immunostaining. Results from these 4 cats provide evidence that FcaPV-3 could cause a proportion of feline skin cancers, albeit less frequently than FcaPV-2. Excision of the typical BISCs and the BCCs appeared curative. Although the cat with the unusual BISC was euthanized because of the large size of the lesion, evidence from these 4 cats suggests that skin neoplasms that contain FcaPV-3 DNA may have a less aggressive clinical behavior than those associated with FcaPV-2. A consistent feature of the neoplasms in all 4 cats was the presence of prominent basophilic intracytoplasmic inclusion bodies; these inclusions have not been reported in lesions caused by FcaPV-2, to our knowledge, and their detection may allow differentiation between the different PV types and could therefore be a useful prognostic feature.


Assuntos
Doença de Bowen/veterinária , Carcinoma Basocelular/veterinária , Doenças do Gato/diagnóstico , Papillomaviridae/isolamento & purificação , Neoplasias Cutâneas/veterinária , Animais , Doença de Bowen/diagnóstico , Doença de Bowen/virologia , Carcinoma Basocelular/diagnóstico , Carcinoma Basocelular/virologia , Doenças do Gato/virologia , Gatos , DNA Viral/genética , Diagnóstico Diferencial , Masculino , Papillomaviridae/genética , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/virologia
3.
Vet Dermatol ; 27(3): 215-e55, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27188773

RESUMO

BACKGROUND: Bowenoid in situ carcinomas (BISCs) are rare feline tumours that are thought to be caused by papillomavirus infection. Although they usually develop in old cats and are slowly progressive, multiple aggressive BISCs have been reported previously in a comparatively young Devon Rex cat. ANIMALS: A 5-year-old (Case 1) and an 8-year-old (Case 2) Devon Rex cat developed numerous BISCs. Rapid progression resulted in euthanasia of both cats after 8 months. A postmortem examination was possible only for Case 2 and revealed pulmonary metastases. METHODS AND RESULTS: Consensus PCR amplified only Felis catus papillomavirus type 2 (FcaPV-2) DNA from lesions from both cats. High FcaPV-2 copy number and FcaPV-2 E6/E7 gene expression were detected in a BISC from Case 1. High FcaPV-2 copy number and FcaPV-2 gene expression were detected in a BISC, a cutaneous squamous cell carcinoma (SCC) and the pulmonary metastases from Case 2, but not in two other cutaneous SCCs. CONCLUSIONS: The results provide additional evidence that BISCs develop at a younger age in Devon Rex cats and that BISCs in Devon Rex cats have a more aggressive behaviour than BISCs in other cat breeds. These unusual features should be considered when evaluating and treating skin disease in Devon Rex cats. The detection of FcaPV-2 gene expression in the lung neoplasms suggests a potential role of FcaPV-2 in the development of metastatic disease. However, the absence of FcaPV-2 gene expression in two cutaneous SCCs suggests that other factors could have also promoted cancer development.

4.
J Vet Diagn Invest ; 18(6): 619-22, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17121097

RESUMO

A 7-year-old dairy cow presented with clinical signs of neurologic disease. Despite treatment with penicillin, the cow died 36 hours after initial presentation. Necropsy examination revealed multiple foci of hemorrhage within the cerebrum and thickened meninges. Additionally, endometritis and consolidation of approximately 30% of both lungs was observed. Histology revealed necrotizing vasculitis, infarction, and hemorrhage within sections of the brain, uterus, and lung. Large numbers of intralesional fungal hyphae were visible. Because only formalin-fixed tissue was available, polymerase chain reaction was used to make an etiologic diagnosis of Mortierella wolfii.


Assuntos
Doenças dos Bovinos/microbiologia , Meningoencefalite/veterinária , Mortierella/isolamento & purificação , Mucormicose/veterinária , Animais , Autopsia/veterinária , Bovinos , Doenças dos Bovinos/patologia , Cérebro/microbiologia , Cérebro/patologia , Evolução Fatal , Feminino , Meningoencefalite/microbiologia , Meningoencefalite/patologia , Mortierella/genética , Mucormicose/diagnóstico , Mucormicose/patologia , Reação em Cadeia da Polimerase
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