RESUMO
BACKGROUND: South American blastomycosis is primarily a lung infection often complicated by multiorgan or intracranial disease. MATERIAL AND METHODS: We describe the clinical and pathological findings of fatal cerebral blastomycosis occurring in a woman that immigrated to Norway from Brazil 23 years earlier. RESULTS: The clinical symptoms together with the radiological findings of multiple cerebral lesions and thickening of the basal meninges were interpreted as cerebral tuberculosis. Examination of cerebral spinal fluid was inconclusive. A diagnosis of cerebral fungal infection was subsequently established by brain biopsy. INTERPRETATION: This case history stresses the importance of confirming a clinical diagnosis by brain biopsy and extended investigation of the cerebrospinal fluid when intracranial lesions may have an infectious origin.
Assuntos
Meningite Fúngica/diagnóstico , Paracoccidioidomicose/diagnóstico , Tuberculose Meníngea/diagnóstico , Diagnóstico Diferencial , Evolução Fatal , Feminino , Humanos , Imageamento por Ressonância Magnética , Meningite Fúngica/patologia , Pessoa de Meia-Idade , Paracoccidioidomicose/patologia , Tuberculose Meníngea/patologiaRESUMO
Neuronal migration disorders can cause congenital cerebral malformations during the third and fourth months of gestation. They are usually classified as agyria, pachygyria, schizencephaly, polymicrogyria and heterotopic gray matter. The best diagnostic tool for detecting neuronal migration disorders is magnetic resonance imaging (MRI). Frequently, the migration disorders are associated with epilepsy, psychomotor retardation and cerebral palsy, and patients with these symptoms should always be investigated by cerebral MRI. In this article we discuss radiologic and clinical aspects in the case of six persons with different categories of migration disorders.
Assuntos
Anormalidades Múltiplas/diagnóstico , Encefalopatias/diagnóstico , Encéfalo/anormalidades , Anormalidades Múltiplas/genética , Anormalidades Múltiplas/patologia , Adulto , Encéfalo/patologia , Encefalopatias/genética , Encefalopatias/patologia , Pré-Escolar , Eletroencefalografia , Epilepsia/diagnóstico , Epilepsia/genética , Epilepsia/patologia , Feminino , Humanos , Lactente , Deficiência Intelectual/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Neurônios/patologiaRESUMO
The aim of this study was to further investigate the possibilities and limitations of the newborn piglet as a model for neonatal cerebral circulation and injury. The precerebral and cerebral circulation was visualized by aortic arch contrast injection and selective injections into internal carotid and vertebral arteries. Due to the well-developed collateral circulation, it is not possible to produce severe focal cerebral ischemia in the piglet by ligation of extracranial arteries. It is possible to produce a modified common carotid artery which supplies mainly intracerebral tissues and is accessible for continuous measurements of cerebral blood flow.