[Flurbiprofen collutory in oral surgical pathology]. / Flurbiprofen collutorio nella patologia chirurgica orale.

This study was carried out in a group of 40 patients (both sexes) aged between 18 and 65 years old. The following pathologies were controlled and studied using collutory flurbiprofen: aphthous stomatitis, pressure ulcer caused by badly fitted mobile prostheses, radicular residue, particularly sharp and cutting dental cusps, pre-and postoperative treatment for the diagnosis of embedded 8th. The topical use of collutory flurbiprofen enabled a rapid resolution of phlogosis and painful symptoms to be achieved. The positive results obtained using collutory flurbiprofen in the aforesaid pathologies prompted the authors to evaluate the efficacy of the product, which is still undergoing trials, also in lichen ruber planus and leukoplakia.

[Flurbiprofen in oral surgery]. / Flurbiprofen nella chirurgia stomatologica.

Odontic surgery necessitates the very frequent use of additional auxiliary therapy to improve the post-operative symptoms. In fact the injured tissues respond to such surgical operations generally with an infiltrative-type process which is manifested predominantly by pain, pyrexia, oedema and in the more serious cases with total functional incapacity. The therapy for such symptomatology usually consists of NSAID, steroidal anti-inflammatories and/or chemotherapy. The scope of this research was to verify the possibility of utilising, exclusively, a potent non steroidal antiinflammatory whilst evaluating its therapeutic effects on the pain, the pyrexia and the oedema sustained following odontic surgery. The drug under examination was flurbiprofen, a medication with powerful antiinflammatory, analgesic and antipyretic properties whose mode of action, typical of this type of drug, is principally explained by its inhibition of prostaglandins biosynthesis. Moreover, flurbiprofen has been shown to be a potent inhibitor of platelet aggregation and of the migration of leucocytes. It has other pharmacological mechanisms of action but so far these remain insufficiently well explained. For the above mentioned study, 50 patients who had consented to take part were to undergo odontic surgery near to our clinic. They were subdivided into two groups, each consisting of 25 subjects, and each group was assigned an exclusive therapeutic regimen based on flurbiprofen. Patients in the first group were administered a flurbiprofen dose of 300 mg/day, by mouth, commencing on the day preceding the surgery and then on the next 7 consecutive days.(ABSTRACT TRUNCATED AT 250 WORDS)

[The prognostic correlation between a delay in the diagnosis and the survival of patients with malignant tumors of the oral cavity]. / Correlazione prognostica fra ritardo nella diagnosi e sopravvivenze nei pazienti affetti da tumori maligni della cavità orale.

The results obtained in the analysis of a series of patients suffering from malignant tumours of the oral cavity, all of whom died as a result of the primary pathology, are reported. The initial diagnostic delay is particularly examined, correlating this with survival times so as to monitor in statistically correct fashion and evaluate the influence of diagnosis-therapy latency on prognosis.