[The effect of intermittent hypoxic training on pancreatic endocrine function in animals with diabetes mellitus]. / Vplyv interval'nykh hipoksychykh trenuval' na stan endokrynnoï funktsiï pidshlunkovoï zalozy u tvaryn z tsukrovym diabetom.

The state of the pancreatic endocrine apparatus in diabetes, adaptation to hypoxia and both of them were studied in experiments with rats. Early stages of diabetes were accompanied by marked reconstruction of the pancreas. A decrease in the insulin level was followed by compensatory activation of glucagon- and somatostatine-producing systems which depended on the sex of animals. It was observed that adaptation to intermittent hypoxia exerted a positive effect on the diabetic process in rats, which was manifested by an increase in the insulin level in blood and beta-cells, inhibition of islet destruction, new formation of beta-cells in acinar tissue, and decrease of glucagon and somatostatine production.

[Interactions of the macrocellular neurosecretory system of the hypothalamus and the endocrine pancreas of rats in adaptation to hypoxia]. / Vzaiemovidnoshennia krupnoklitynnoi neirosekretornoi systemy gipotalamusa ta endokrynnoi chastyny pidshlunkovoi zalozy v umovakh adaptatsii do gipoksii.

Daily hypoxia (6 h, 6000 m) changed the functional state of endocrine pancrease of male and female Wistar rats. The actions of hypoxia on functional state of supraoptic (SO) and paraventricular (PV) nuclei of hypothalamus and islet cells of endocrine pancreas were examined using immunocytochemical, histochemical, morphometric and radioimmunoassay methods. Increase of insulin biosynthesis in beta cells and glucagon secretion of alpha cells, and decrease of the somatostatin contents in delta cells of pancrease islets have been investigated. The functional activity of vasopressinergic magnocellular subnucleus of PV increased, but that of SO decreased with reduction of vasopressin blood concentration at the same time. The functional state of oxytocin synthesis subdivisions of PV and SO were sex dependent, but the oxytocin contents in median eminence increased.