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Int J Surg ; 7(2): 163-7, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19342323

RESUMO

PURPOSE: The effects on gastric emptying of feeding with a normal diet (ND), an early high-calorie and hyperosmolar diet (HCHOD) or normal diet plus intraperitoneal loxiglumide (LOX) were investigated in rats with antecolic (ACGJ) or retrocolic (RCGJ) gastrojejunostomy. METHODS: Sixty rats were separated into six groups of ten animals each (ACGJ+ND, RCGJ+ND, ACGJ+HCHOD, RCGJ+HCHOD, ACGJ+ND+LOX, and RCGJ+ND+LOX). On the seventh day, scintigraphic measurements of solid gastric emptying were made at 1, 30 and 60 min. RESULTS: According to the 60-min results, the RCGJ+ND group exhibited delayed emptying compared to the ACGJ+ND group (p=0.023). Gastric emptying of ACGJ+HCHOD rats was delayed compared with the other ACGJ groups (compared to ACGJ+ND: p=0.000, and ACGJ+ND+LOX: p=0.015). Gastric emptying was more effective in the RCGJ+ND+LOX group than the other RCGJ groups (compared to RCGJ+ND: p=0.003, and RCGJ+HCHOD: p=0.001). CONCLUSION: Antecolic gastrojejunostomy provided better gastric emptying. An early high-calorie and hyperosmolar enteral diet delayed gastric emptying in both types of anastomosis.


Assuntos
Nutrição Enteral , Derivação Gástrica/métodos , Esvaziamento Gástrico/fisiologia , Antagonistas de Hormônios/farmacologia , Proglumida/análogos & derivados , Anastomose Cirúrgica/métodos , Animais , Colecistocinina/antagonistas & inibidores , Modelos Animais de Doenças , Feminino , Esvaziamento Gástrico/efeitos dos fármacos , Jejuno/cirurgia , Masculino , Proglumida/farmacologia , Ratos , Ratos Wistar , Estômago/cirurgia
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