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2.
J Small Anim Pract ; 45(1): 29-31, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-14756207

RESUMO

Tracheal narrowing is described in two cats. In both cases, inspiratory radiographs demonstrated tracheal narrowing just cranial to the thoracic inlet; no narrowing was seen on expiratory radiographs. Magnetic resonance imaging revealed suspected nasal tumours in both cases, but no abnormalities were identified in the region of the narrowed trachea. Nasal biopsy confirmed intranasal lymphoma in one cat and nasal adenocarcinoma in the other. The former cat was treated with chemotherapy. The owner of the latter cat declined further treatment. The tracheal narrowing disappeared after the initiation of chemotherapy in the cat with intranasal lymphoma and it is suggested that the narrowing might have been associated with the nasal tumour. A careful evaluation of the airway, especially cranial to the narrowing, is recommended in cases of tracheal narrowing in cats.


Assuntos
Adenocarcinoma/veterinária , Doenças do Gato/diagnóstico , Linfoma/veterinária , Obstrução Nasal/veterinária , Neoplasias Nasais/veterinária , Adenocarcinoma/complicações , Adenocarcinoma/diagnóstico , Animais , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doenças do Gato/diagnóstico por imagem , Doenças do Gato/tratamento farmacológico , Doenças do Gato/patologia , Gatos , Diagnóstico Diferencial , Linfoma/complicações , Linfoma/diagnóstico , Masculino , Obstrução Nasal/diagnóstico , Obstrução Nasal/etiologia , Neoplasias Nasais/complicações , Neoplasias Nasais/diagnóstico , Radiografia
3.
J Vet Med Sci ; 62(10): 1115-9, 2000 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11073087

RESUMO

The prostatic regression effect of oral administration of a new steroidal anti-androgen, osaterone acetate, was investigated in dogs with prostatic hypertrophy. To dogs with prostatic hypertrophy, 0.1-1.0 mg/kg of osaterone acetate was orally administered for one week, and the regression rate was observed. It was shown that administration of osaterone acetate at 0.2 mg/kg or higher, sharply regressed prostatic hypertrophy during the early stage. Therefore, this agent may be clinically applicable as a therapeutic agent for benign prostatic hypertrophy.


Assuntos
Antagonistas de Androgênios/uso terapêutico , Acetato de Clormadinona/uso terapêutico , Doenças do Cão/tratamento farmacológico , Hiperplasia Prostática/veterinária , Administração Oral , Antagonistas de Androgênios/administração & dosagem , Antagonistas de Androgênios/sangue , Animais , Acetato de Clormadinona/administração & dosagem , Acetato de Clormadinona/análogos & derivados , Acetato de Clormadinona/sangue , Doenças do Cão/sangue , Cães , Hormônio Luteinizante/sangue , Masculino , Hiperplasia Prostática/tratamento farmacológico , Testosterona/sangue
4.
Vet Pathol ; 37(5): 499-501, 2000 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11055882

RESUMO

Microcystic hamartoma was detected as a tumorlike mass in the left caudal lung lobe of a 12-year-old mixed-breed dog. Histologically, the mass was characterized by microcysts of various sizes that mimicked alveoli and were surrounded by thin fibrous septal tissue. However, unlike the adjacent lung parenchyma, bronchial or bronchiolar trees were absent, and the septal vascular channels were extremely underdeveloped. Immunohistochemically, the cells lining the microcysts were consistently positive for cytokeratin but not for vimentin, whereas the septal fibroblast-like cells were negative for cytokeratin and positive for vimentin. Electron microscopy confirmed that the microcysts were lined with a layer of type I and type II mature pneumocytes. This is the first description of the detailed morphologic features of microcystic hamartoma.


Assuntos
Doenças do Cão/patologia , Hamartoma/veterinária , Pneumopatias/veterinária , Animais , Doenças do Cão/cirurgia , Cães , Hamartoma/patologia , Hamartoma/cirurgia , Pulmão/diagnóstico por imagem , Pulmão/patologia , Pneumopatias/patologia , Pneumopatias/cirurgia , Microscopia Eletrônica/veterinária , Ultrassonografia
5.
Int J Androl ; 21(2): 67-73, 1998 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9675615

RESUMO

Eight beagles with benign prostatic hypertrophy (BPH) were treated by subcutaneous implantation of pellets containing 10 mg/kg chlormadinone acetate (CMA), a synthetic anti-androgen, plus daily oral administration of CMA at 2 mg/kg per day for 7 days as a therapy for BPH. Prostatic and testicular size were measured and prostatic and testicular biopsies were performed by laparotomy before and after CMA treatment. Plasma levels of luteininzing hormone (LH), testosterone and oestradiol were also measured. The clinical signs of BPH, for example haematuria and dysuria, resolved within 1 week of treatment. Mean prostatic volume decreased to 56% of the pretreatment value. At 40 weeks after treatment, prostatic volume had decreased by 36%. Histological examination of the prostate 1 week after treatment revealed reduction in diameter of the alveoli and in height of the glandular epithelium. Degeneration and atrophy of the glands were marked 4-12 weeks after treatment. In the testis, the diameter of seminiferous tubules and the number of germ cells in the seminiferous tubules had decreased markedly at 12 and 24 weeks after treatment. Although plasma LH concentrations did not undergo any marked fluctuations after CMA treatment, levels of testosterone and oestradiol were lower than before treatment. The results indicate that implantation of 10 mg/kg CMA, plus 7-day oral administration of 2 mg/kg CMA, bring about resolution of the clinical signs and marked reduction in prostatic volume within 1 week of treatment.


Assuntos
Antagonistas de Androgênios/uso terapêutico , Acetato de Clormadinona/uso terapêutico , Hiperplasia Prostática/tratamento farmacológico , Administração Oral , Antagonistas de Androgênios/administração & dosagem , Animais , Acetato de Clormadinona/administração & dosagem , Cães , Implantes de Medicamento , Estradiol/sangue , Hormônio Luteinizante/sangue , Masculino , Próstata/patologia , Hiperplasia Prostática/patologia , Testículo/patologia , Testosterona/sangue
6.
J Vet Med Sci ; 59(8): 729-31, 1997 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9300375

RESUMO

Neurogenic muscular atrophy was examined using computed tomography (CT) in dogs induced by crushing the sciatic nerve. The CT number and cross-sectional area in denervated muscles decreased in 1 to 2 weeks after denervation. Those were significant after 3 weeks. The examination with CT might be useful to diagnose canine neurogenic muscular atrophy.


Assuntos
Músculo Esquelético/diagnóstico por imagem , Atrofia Muscular/diagnóstico por imagem , Nervo Isquiático , Tomografia Computadorizada por Raios X/veterinária , Animais , Cães , Fêmur , Denervação Muscular , Músculo Esquelético/inervação , Atrofia Muscular/etiologia , Compressão Nervosa , Fatores de Tempo , Tomografia Computadorizada por Raios X/métodos
7.
Crit Care Med ; 23(12): 2029-37, 1995 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-7497726

RESUMO

OBJECTIVE: To compare the pathophysiologic changes occurring during drowning in cold fresh water and cold salt water with reference to viability. DESIGN: Randomized, prospective, controlled submersion experiments in two contrasting cold liquids. SETTING: A laboratory at a large university-affiliated medical institution. SUBJECTS: Thirteen healthy, anesthetized mongrel dogs. Three dogs served as controls and were immersed but not submerged. The remainder were submerged in cold fresh water or cold salt water (4 degrees C). INTERVENTIONS: Catheters were placed in the femoral artery, right carotid artery and right internal jugular vein. Electrocardiogram, pneumogram, and rectal temperatures were measured continuously during submersion/immersion. MEASUREMENTS AND MAIN RESULTS: Cold water submersion with drowning produced a large initial decrease in carotid artery temperature (approximately 7.5 degrees C in the first 2 mins) compared with a minor decrease (approximately 0.8 degrees C with immersion). No significant differences were noted in the rate of decrease of temperature between drowning in fresh water and salt water. During cold fresh water drowning, aspiration produced gross hemodilution with an average increase in body weight of 16.5%. Hematocrit values, serum sodium concentrations, and osmolality decreased while serum potassium concentrations, catecholamines, and free hemoglobin increased. All measured biochemical data (except PaO2) remained at viable levels. By contrast, during cold salt water drowning, average body weight increased by only 6%, with hemoconcentration and a shrinkage of vascular volume. Hematocrit and hemoglobin values increased by 30%, but initial plasma free hemoglobin values remained unchanged. Serum sodium concentrations, osmolality, and potassium concentrations increased rapidly to critical levels. CONCLUSIONS: On submersion in cold water, all of the experimental animals developed tachypnea immediately, followed by aspiration with predictable effects. The biochemical and pathophysiologic changes in cold water drowning approximated those changes reported for warm water drowning for both fresh and salt water with one exception and continued aspiration of cold water produced extremely rapid core cooling as long as the circulation remained intact. This process of acute submersion hypothermia may protect the brain temporarily from lethal damage, as reported in cases of cold fresh water drowning. Concentrations of circulating catecholamines increased exponentially in both groups of test animals. Clinically, their acute effects on the circulation, compounded by significant hypothermia and extreme anoxia, must hamper the detection of residual circulation at rescue and may play a role in sudden death from cold water in the absence of drowning.


Assuntos
Afogamento/fisiopatologia , Animais , Temperatura Corporal , Catecolaminas/sangue , Temperatura Baixa , Cães , Eletrocardiografia , Frequência Cardíaca/fisiologia , Hemodiluição , Potássio/sangue , Estudos Prospectivos , Distribuição Aleatória , Respiração/fisiologia , Sódio/sangue , Cloreto de Sódio , Água
8.
Int J Androl ; 18(5): 248-55, 1995 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8567095

RESUMO

Five beagles out of 11 dogs aged 7-10 years with benign prostatic hypertrophy (BPH) were implanted subcutaneously with pellets of the synthetic anti-androgen chlormadinone acetate (CMA) at a dose of 10 mg/kg bodyweight. The remaining six dogs (one beagle and five mongrel dogs) underwent bilateral orchidectomy. Changes in prostatic volume, histological findings in the prostate and the testis, and peripheral plasma levels of LH, testosterone and oestradiol-17 beta (E2) were assessed up until 24 and 4 weeks after CMA-implantation and orchidectomy, respectively. Measurements of the size of the prostate and biopsies of the prostate were performed by laparotomy. Mean prostatic volume had decreased to 71% and 41%, respectively, of its pretreatment volume, by 4 weeks after CMA-implantation and orchidectomy, and was 49% and 47%, respectively, of pretreatment volume at 12 and 24 weeks after CMA-implantation. The clinical signs of BPH, e.g. haematuria, resolved within 2 weeks after either treatment. When the prostate was examined histologically 4 weeks after either treatment, hardly any evidence of active secretion (e.g. glandular epithelium projecting markedly into the lumen), was observed in CMA-implanted dogs, alveolar diameter and height of the glandular epithelium had decreased markedly and the glandular lumen had become very small in the orchidectomized dogs. By 12 weeks after CMA-implantation, degenerative and atrophic glands were observed in the prostate nearly the same as at 4 weeks after orchidectomy. In the testis the number of germ cells in the seminiferous tubules decreased markedly after CMA-implantation. The mean level of plasma LH at 4 weeks after orchidectomy had increased to 14.9 ng/ml, twice the value before operation. The mean levels of plasma testosterone and E2 at 4 weeks after CMA-implantation had decreased to 0.7 ng/ml and 9 pg/ml from 1.5 ng/ml and 15 pg/ml, the values before treatment, respectively. CMA-implantation resulted in poor semen quality. The results indicate that CMA-implantation at a dose of 10 mg/kg results in the same prostate-shrinking effect as orchidectomy.


Assuntos
Acetato de Clormadinona/uso terapêutico , Doenças do Cão , Orquiectomia , Hiperplasia Prostática/veterinária , Animais , Biópsia , Acetato de Clormadinona/administração & dosagem , Anticoncepcionais Orais Sintéticos/administração & dosagem , Anticoncepcionais Orais Sintéticos/uso terapêutico , Cães , Implantes de Medicamento , Masculino , Próstata/efeitos dos fármacos , Próstata/patologia , Hiperplasia Prostática/fisiopatologia , Hiperplasia Prostática/terapia , Sêmen/química , Sêmen/efeitos dos fármacos , Sêmen/fisiologia , Túbulos Seminíferos/efeitos dos fármacos , Túbulos Seminíferos/patologia , Testículo/efeitos dos fármacos , Testículo/patologia
9.
J Vet Med Sci ; 57(3): 395-9, 1995 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7548388

RESUMO

Chlormadinone acetate (GS implant, CMA) pellet, a synthetic luteal hormone preparation, was subcutaneously implanted at 5, 10 and 20 mg/kg in four normal male dogs ranging in age from 3 to 10 years to determine the changes in the prostatic volume, peripheral plasma levels of sex hormones and semen quality. The plasma levels of CMA, LH, testosterone (T) and 5 alpha-dihydrotestosterone (DHT) were measured by radioimmunoassay. The prostatic volume was measured by computed tomography. The semen was collected by digital manipulation. The pellet was removed 26 weeks after implantation. The effects of CMA pellet implantation were examined during implantation and until 22 weeks after removal. The prostatic volume was reduced to 61 +/- 3 (mean +/- S.E., n = 4), 52 +/- 5 (n = 4) and 53 +/- 9 (n = 4)% of the preimplantation volumes in the 5, 10 and 20 mg/kg groups, respectively. The plasma CMA levels in the 10 mg/kg and 20 mg/kg groups peaked at 2 weeks, but were gradually decreased. At 22 weeks after removal of the pellet, the prostatic volume returned to 74-85% of the preimplantation volumes. The plasma LH levels tended to increase after implantation in all groups. The plasma T and DHT levels were slightly decreased in all groups. In the 10 and 20 mg/kg groups, the number of sperm and motility sperm was reduced, and the rate of abnormal sperm increased.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Acetato de Clormadinona/farmacologia , Di-Hidrotestosterona/sangue , Hormônio Luteinizante/sangue , Congêneres da Progesterona/farmacologia , Próstata/anatomia & histologia , Sêmen/fisiologia , Testosterona/sangue , Envelhecimento/fisiologia , Animais , Acetato de Clormadinona/administração & dosagem , Acetato de Clormadinona/sangue , Doenças do Cão , Cães , Relação Dose-Resposta a Droga , Implantes de Medicamento , Masculino , Congêneres da Progesterona/administração & dosagem , Congêneres da Progesterona/sangue , Próstata/efeitos dos fármacos , Próstata/crescimento & desenvolvimento , Hiperplasia Prostática/tratamento farmacológico , Hiperplasia Prostática/veterinária , Sêmen/efeitos dos fármacos , Motilidade dos Espermatozoides/efeitos dos fármacos , Espermatozoides/anormalidades , Espermatozoides/efeitos dos fármacos , Fatores de Tempo
10.
J Vet Med Sci ; 57(1): 139-41, 1995 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-7538794

RESUMO

Ten beagle dogs (4-8 years of age) with benign prostatic hypertrophy were treated daily for 7 or 14 days by a daily oral administration of chlormadinone acetate (CMA), an anti-androgenic preparation, at a dose of 0.5 or 2.0 mg/kg/day. The groups of dogs treated with CMA at a dose of 2.0 mg/kg showed a greater reduction of the prostatic volume during 7 or 14 days of treatment than the group treated with 0.5 mg/kg of CMA. At 56 and 84 days after the start of CMA treatment, prostate volume was reduced to 63 and 79% of the pre-administration volume, respectively. No marked decrease in plasma LH or testosterone was found after the CMA treatment. These results indicate that the therapeutic effects of 7-day oral treatment with CMA at 2.0 mg/kg/day in dogs with BPH last for about three months or longer without side effects.


Assuntos
Acetato de Clormadinona/uso terapêutico , Doenças do Cão/tratamento farmacológico , Hiperplasia Prostática/veterinária , Administração Oral , Animais , Acetato de Clormadinona/administração & dosagem , Cães , Masculino , Hiperplasia Prostática/tratamento farmacológico
11.
J Vet Med Sci ; 57(1): 105-9, 1995 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-7756399

RESUMO

Canine patellar luxation is seen in toy and miniature breeds, and in the majority of cases the problem is medial patellar luxation. When the luxation is left alone, it causes deformity and disorder in the growth of the affected limb. In severe cases, the limb may cease to afunction. Early surgical correction is therefore essential, but the owners are not able to detect the disorder at an early age and surgical intervention in most cases will take place after 6 months of age. The authors were able to have the opportunity to operate at an earlier age by educating breeders and owners. Various techniques have been developed and implemented to correct this disorder with varying therapeutic results. The authors have devised a unique surgical method which has been applied to the numerous cases with good results since 1985. The procedure is to make a longitudinal groove on the medical cortical bone of the tibial tuberosity along the tibial crest, and to place small pieces of artificial ceramic bone or autoplastic bone grafts in the groove, thus laterally transposing the tibial tuberosity and crest. This method makes it possible to put the quadriceps muscles of the thigh, the patella and the patellar ligament in the correct alignment over the femoral trochlea. It is considered appropriate to conduct this operation at 1.0-3.0 months of age when the dog has matured enough to be able to withstand anesthesia and surgical stress.


Assuntos
Cães/anormalidades , Cães/cirurgia , Luxações Articulares/veterinária , Patela/anormalidades , Patela/cirurgia , Animais , Feminino , Luxações Articulares/congênito , Luxações Articulares/cirurgia , Masculino , Cirurgia Veterinária/métodos
12.
J Vet Med Sci ; 57(1): 133-5, 1995 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-7756406

RESUMO

Surgical removal of an intrathoracic tumor derived from a vagus nerve was undergone in a dog with hypertrophic osteopathy. The tumor was pathologically diagnosed as malignant schwanoma. Soft tissue swelling, lameness, and itchiness in four limbs disappeared within 7 days after surgery. The proliferated periosteal osteophytes of the four limbs was progressively reduced with time by follow-up radiography on the 58th day after surgery. On the 710th day after surgery, these osteophytes were greatly decreased as osteopathy, malignant schwanoma.


Assuntos
Doenças Ósseas/veterinária , Neoplasias dos Nervos Cranianos/veterinária , Doenças do Cão/cirurgia , Vagotomia/veterinária , Nervo Vago , Animais , Doenças Ósseas/etiologia , Doenças Ósseas/terapia , Neoplasias dos Nervos Cranianos/complicações , Neoplasias dos Nervos Cranianos/cirurgia , Cães , Hipertrofia/etiologia , Hipertrofia/terapia , Hipertrofia/veterinária , Masculino , Neurilemoma/complicações , Neurilemoma/cirurgia , Neurilemoma/veterinária
13.
J Vet Med Sci ; 56(6): 1041-5, 1994 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-7696390

RESUMO

Transverse diaphyseal fractures of the femur were experimentally made in immature cats, and were fixed by an intramedullary pinning technique using an uniaxially oriented poly-L-lactide (PLLA) rod, a biodegradable polymer. The healing process was evaluated radiographically and histologically. Formation of bony callus was completed in 8 weeks, and cortical bony union followed. The remodeling process was then observed form 12 to 16 weeks. The healing process was almost the same as when a metallic implant was used. Abundant periosteal callus formation may be attributable to the lower elasticity of the PLLA rod compared with metallic implants. Since no other abnormalities such as growth deformities were detected, it was concluded that the combined use of a uniaxially oriented PLLA rod and an external splint is clinically useful for the repair of diaphyseal fractures in immature cats.


Assuntos
Pinos Ortopédicos , Gatos/lesões , Gatos/cirurgia , Fraturas do Fêmur/veterinária , Poliésteres , Animais , Diáfises/diagnóstico por imagem , Diáfises/lesões , Diáfises/cirurgia , Feminino , Fraturas do Fêmur/diagnóstico por imagem , Fraturas do Fêmur/patologia , Fraturas do Fêmur/cirurgia , Fixação Intramedular de Fraturas/veterinária , Masculino , Radiografia
14.
J Vet Med Sci ; 56(6): 1187-9, 1994 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-7696417

RESUMO

A retrograde angiography method for the detection of a portosystemic shunt was studied. The retrograde angiography was done by compressing the caudal vena cava in the chest by applying pressure to the thoracic cavity, then feeding a contrast medium into the caudal vena cava without releasing the pressure loading. The angiography could detect shunt vessels in experimental cases as well as clinical cases. This method is useful for the confirmation of a portal-caudal caval shunt, which can be performed without technical difficulty and without the need for a special kind of catheter.


Assuntos
Doenças do Cão/diagnóstico por imagem , Veia Porta/diagnóstico por imagem , Veia Cava Inferior/diagnóstico por imagem , Angiografia/veterinária , Animais , Cães , Masculino , Derivação Portocava Cirúrgica/veterinária , Doenças Vasculares/diagnóstico por imagem , Doenças Vasculares/veterinária
15.
J Vet Med Sci ; 56(5): 817-22, 1994 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-7865578

RESUMO

The clinical usefulness of biodegradable oriented poly-L-lactide (PLLA) screws for experimental Salter-Harris type 4 fracture in the distal femoral condyle of dogs was evaluated. Bony union of the osteotomized fragment of the condyle was almost completed radiographically and histologically within 1 to 2 months after surgery, suggesting that PLLA screws maintained strength long enough to fix the fragment until bone healing. At 4 to 6 months after surgery, minute fissures were histologically confirmed on the surface of the screw thread, suggesting the early stage of biodegradation and absorption of the polymer. During the observational period, no significant difference between the treated femur and the contralateral non-treated femur in either total femoral length or maximum condyle width was observed, indicating no growth disturbance in the treated femur. From these results it was concluded that the PLLA screw might be an ideal implant for the reduction and fixation of epiphyseal plate fractures such as Salter-Harris type 3 or type 4 fractures.


Assuntos
Parafusos Ósseos/veterinária , Doenças do Cão , Fraturas do Fêmur/veterinária , Animais , Cães , Feminino , Fraturas do Fêmur/diagnóstico por imagem , Fraturas do Fêmur/cirurgia , Masculino , Poliésteres , Radiografia
16.
J Vet Med Sci ; 56(5): 923-8, 1994 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-7865595

RESUMO

To compare the cardiovascular effects of dibutyryl cyclic AMP (DBcAMP) and milrinone, we used the right heart bypass method in intact anesthetized dogs. The preload of the left ventricle was maintained constant throughout the experiment. Therefore, the effects of DBcAMP and milrinone on cardiac contractility and afterload of the left ventricle were investigated respectively without preload influence. DBcAMP and milrinone exhibited marked positive chronotropic-, positive inotropic-, vasodilative- and diuretic-activity. DBcAMP expressed these effects gradually and continuously, whereas milrinone expressed its pharmacological actions rapidly, but for a short duration of time. Both the afterload-reducing and the cardiac contractile force-enhancing activities of DBcAMP were longer lasting than those of milrinone. Mean arterial pressure was not altered by DBcAMP infusion, whereas it was increased significantly (p < 0.05) by milrinone infusion. The results of this study suggested that DBcAMP appeared to be indicated when there is a need to increase cardiac output by reducing afterload and increasing cardiac contractile force gradually and continuously. On the other hand, milrinone would seem to be indicated when the goal is to raise blood pressure rapidly and to increase cardiac output simultaneously.


Assuntos
Bucladesina/farmacologia , Cardiotônicos/farmacologia , Ponte de Artéria Coronária/veterinária , Hemodinâmica/efeitos dos fármacos , Piridonas/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Débito Cardíaco/efeitos dos fármacos , Diurese/efeitos dos fármacos , Cães , Circulação Extracorpórea , Frequência Cardíaca/efeitos dos fármacos , Milrinona , Circulação Pulmonar/efeitos dos fármacos , Volume Sistólico/efeitos dos fármacos , Resistência Vascular/efeitos dos fármacos , Função Ventricular Esquerda
17.
J Vet Med Sci ; 56(4): 791-4, 1994 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7999915

RESUMO

Computed tomography after myelography (CTM) was performed pre- and postoperatively on four dogs diagnosed as having cervical intervertebral disc protrusion. The surgery was performed by ventral slot technique in all the cases. The direction of the ventral slot was precisely adjusted according to the location of the protruded discs as seen on CTM. Postoperative values for the transversal area of the spinal cord were greater than those measured preoperatively, suggesting effective decompression of the cord. The prognosis for these patients was excellent. In view of these results, it was considered that preoperative confirmation of the positional relationship between the spinal cord and the protruded disc by CTM was quite useful in planning the surgical technique for disc disease in the dog.


Assuntos
Vértebras Cervicais , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia , Deslocamento do Disco Intervertebral/veterinária , Animais , Cães , Feminino , Deslocamento do Disco Intervertebral/diagnóstico por imagem , Deslocamento do Disco Intervertebral/cirurgia , Masculino , Mielografia , Prognóstico , Tomografia Computadorizada por Raios X
18.
J Vet Med Sci ; 56(3): 607-9, 1994 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7948406

RESUMO

We studied the pressure-volume (PV) relationships of the total respiratory system, lung and chest wall in 8 anesthetized and paralyzed normal adult cats. The PV relationships of the total respiratory system had a sigmoid shape with a relatively linear portion with an alveolar pressure between 0 to +15 cmH2O. The relative impact of the lung and chest wall to the total elastic recoil forces of the respiratory system was approximately equal within a physiological pressure range. The results suggest that measurements of PV relationships of the respiratory system may offer a physiologic basis for accurate interpretation of pulmonary functions, leading to a better therapeutic strategy in animals with lung diseases.


Assuntos
Gatos/fisiologia , Pulmão/fisiologia , Fenômenos Fisiológicos Respiratórios , Animais , Relaxamento Muscular , Pleura/fisiologia , Pressão , Alvéolos Pulmonares/fisiologia , Respiração Artificial , Tórax/fisiologia
19.
J Vet Med Sci ; 56(1): 131-4, 1994 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-8204737

RESUMO

The aim of these studies was to investigate the effect of body posture on circulatory and respiratory system function in unmediated cattle. The plasma cortisol concentration was also measured and served as an indication of the level of stress imposed by animal handling and positional manipulation. Six mature, healthy Holstein cows were physically restrained and studied in standing, supine and right lateral postures. The plasma cortisol concentration increased with the change in body position. In a supine position, the value was increased to more than three times the control value (p < 0.001). The arterial oxygen tension and oxygen saturation were significantly decreased (p < 0.001) with changes in body position. The decrease was most pronounced when cattle were restrained in a supine position. Arterial carbon dioxide tension, heart rate, mean arterial pressure and central venous pressure did not change significantly with changes in body posture. Restraining of cattle in a lateral recumbent or supine position without introducing anesthesia was found to exert a strong stress which affected the respiratory function and increased the plasma cortisol level.


Assuntos
Bovinos/fisiologia , Hemodinâmica , Hidrocortisona/sangue , Postura/fisiologia , Respiração , Animais , Bicarbonatos/sangue , Glicemia/metabolismo , Pressão Sanguínea , Dióxido de Carbono/sangue , Eletrocardiografia/veterinária , Feminino , Frequência Cardíaca , Oxigênio/sangue , Pressão Parcial
20.
J Vet Med Sci ; 55(4): 631-5, 1993 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7691191

RESUMO

Seven of the 25 dogs (4 to 15 years old) with benign prostatic hypertrophy (BPH) at the teaching hospital of Nippon Veterinary and Animal Science University from 1989 through 1990 were treated orally with chlormadinone acetate (CMA), a synthetic anti-androgen, 2 mg/kg/day, twice a day for 3 or 4 weeks. Prostatic size was measured by radiography and ultrasonography before and after CMA treatment, and prostatic volume was calculated from the images. Semen quality was examined in 3 of the dogs with BPH. Peripheral blood samples were collected and plasma levels of LH, 4-androstenedione, 5 alpha-dihydrotestosterone, testosterone and estradiol-17 beta were measured. Clinical signs disappeared within 10 days after the start of CMA treatment. The mean (+/- S.E.) prostatic volume 3 or 4 weeks after treatment decreased to 39 +/- 4% of the pretreatment volume. The mean level of plasma testosterone in the dogs with BPH before treatment was significantly lower than that in the normal dogs (P < 0.01). In 6 of the CMA-treated dogs the levels of all hormones examined, except LH, were significantly lower after CMA treatment than before (P < 0.05). The sperm count and motility decreased and the percentage of abnormal sperms increased after CMA treatment. These results demonstrate that, although CMA treatment in dogs with BPH inhibits testicular function, the prostatic volume is markedly reduced and clinical signs disappear in a short period after the therapy. However, a relapse of BPH was observed approximately 6 months after oral CMA treatment in some dogs.


Assuntos
Acetato de Clormadinona/farmacologia , Acetato de Clormadinona/uso terapêutico , Doenças do Cão , Hiperplasia Prostática/veterinária , Administração Oral , Androstenodiona/sangue , Animais , Acetato de Clormadinona/administração & dosagem , Di-Hidrotestosterona/sangue , Cães , Estradiol/sangue , Hormônio Luteinizante/sangue , Masculino , Próstata/efeitos dos fármacos , Próstata/patologia , Hiperplasia Prostática/sangue , Hiperplasia Prostática/tratamento farmacológico , Valores de Referência
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