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1.
Gan To Kagaku Ryoho ; 48(9): 1157-1159, 2021 Sep.
Artigo em Japonês | MEDLINE | ID: mdl-34521795

RESUMO

A 77-year-old woman was admitted to our hospital because of right lower abdominal pain. CT revealed tumors in the ileum and uterine cervix. After a gynecological biopsy of the uterine tumor, we diagnosed Stage Ⅳ diffuse large B-cell lymphoma. We treated her with R-THPCOP chemotherapy. On day 8 after the first chemotherapy, she developed perforated peritonitis, and an emergency partial ileum resection was performed. Histopathologically, viable cells were not found in the resected intestine. Chemotherapy was resumed on postoperative day 21, and she achieved a complete response 8 months after the surgery. Gastrointestinal malignant lymphoma is sometimes reported in cases requiring emergency surgery. Therefore, information sharing between hematologist and surgeon is recommended.


Assuntos
Neoplasias do Íleo , Linfoma Difuso de Grandes Células B , Peritonite , Neoplasias do Colo do Útero , Idoso , Feminino , Humanos , Neoplasias do Íleo/tratamento farmacológico , Neoplasias do Íleo/cirurgia , Íleo , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Peritonite/etiologia , Neoplasias do Colo do Útero/cirurgia
2.
Surg Today ; 49(8): 678-685, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30826861

RESUMO

PURPOSE: Surgery remains the best curative treatment option for non-small cell lung cancer (NSCLC), but is of benefit only to patients with localized disease. A meta-analysis showed a significant beneficial effect of induction chemotherapy on survival, but there is still no clear evidence. This phase II study was conducted to establish whether induction chemotherapy with carboplatin (CBDCA) and paclitaxel (PTX) plus bevacizumab prior to surgery reduces the risk of progression. METHODS: The subjects of this study were 29 patients with treatment-naive nonsquamous NSCLC (clinical stages IIIA to IV). Patients received PTX (200 mg/m2), CBDCA (area under the curve, 5), and bevacizumab (15 mg/kg) followed by surgery. Chemotherapy was repeated every 3 weeks for up to six cycles. RESULTS: The overall response rate was 72.4%. Of the 29 patients, ten underwent surgery after the induction chemotherapy and complete resection was achieved in 7 (70%). The median progression-free-survival (PFS) time and the 3-year PFS rate were 0.92 years and 16.2%, respectively. The median overall survival (OS) time and the 3-year OS rate were 1.96 years and 44.9%, respectively. CONCLUSION: Combined modality therapy with surgery after induction chemotherapy with CBDCA and PTX plus bevacizumab is clinically feasible and tolerable for patients with unknown or negative molecular profiles.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma Pulmonar de Células não Pequenas/terapia , Quimioterapia de Indução , Neoplasias Pulmonares/terapia , Idoso , Bevacizumab/administração & dosagem , Carboplatina/administração & dosagem , Carcinoma Pulmonar de Células não Pequenas/mortalidade , Carcinoma Pulmonar de Células não Pequenas/patologia , Terapia Combinada , Feminino , Humanos , Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Paclitaxel/administração & dosagem , Taxa de Sobrevida , Resultado do Tratamento
3.
Surg Today ; 44(7): 1197-206, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23838838

RESUMO

Surgical resection is the accepted standard of care for patients with non-small cell lung cancer (NSCLC). Several imaging modalities play central roles in the detection and staging of the disease. The aim of this review is to evaluate the utility of computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and PET/CT for NSCLC staging. Radiographic staging refers to the use of CT as a non-invasive diagnostic technique. However, while the vast majority of patients undergo only CT, CT is a notoriously inaccurate means of tumor and nodal staging in many situations. PET/CT clearly improves the staging, particularly nodal staging, compared to CT or PET alone. In addition, as a result of the increased soft-tissue contrast, MRI is superior to CT for distinguishing between tissue characteristics. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), which is a minimally invasive technique, also has pathological diagnostic potential. Extensive research and the resultant improvements in the understanding of genetics, histology, molecular biology and oncology are transforming our understanding of lung cancer, and it is clear that imaging modalities such as CT, MRI, PET and PET/CT will have an important role in its preoperative management. However, thoracic surgeons should also be aware of the limitations of these techniques.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/diagnóstico , Neoplasias Pulmonares/diagnóstico , Imageamento por Ressonância Magnética , Tomografia por Emissão de Pósitrons , Cuidados Pré-Operatórios , Tomografia Computadorizada por Raios X , Carcinoma Pulmonar de Células não Pequenas/secundário , Humanos , Neoplasias Pulmonares/patologia , Estadiamento de Neoplasias
4.
World J Surg Oncol ; 11: 113, 2013 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-23705641

RESUMO

BACKGROUND: Adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) with fibrous stromal invasion are newly introduced subtypes of small lung adenocarcinoma. AIS is a small localized adenocarcinoma in which growth is restricted to neoplastic cells along preexisting alveolar structures without fibrous stromal invasion. In MIA, by contrast, tumor cells have infiltrated the myofibroblastic stroma. Transforming growth factor (TGF)-ß is known to be produced by progressor tumors, and excessive TGF-ß contributes to a pathological excess of tissue fibrosis. TGF-ß1 is the most abundant isoform, and its expression is a key event fostering tumor invasion and metastasis. We therefore analyzed the relationship between TGF-ß1 expression and clinicopathological microinvasion in patients with small lung adenocarcinoma. METHODS: The study participants were 45 patients who underwent curative surgery for AIS and MIA 3 cm or less in size. Those tumors were assessed based on immunohistochemical staining using anti-TGF-ß1 antibody. The TGF-ß1 status was assessed immunohistochemically using the Allred 8-unit system. RESULTS: The rates of TGF-ß1 positivity in the AIS and MIA groups were 27.3% and 65.2%, respectively (P <0.05). The median of Allred score was 0.5 (range 0-5) in the AIS group and 3.0 (range 0-6) in the MIA group (P = 0.0017). CONCLUSIONS: We suggest that TGF-ß1 expression is likely to be significantly stronger in patients with MIA than in those with AIS, and the increased expression may be associated with minimal invasion and infiltration of the myofibroblastic stroma.


Assuntos
Adenocarcinoma Bronquioloalveolar/patologia , Adenocarcinoma/patologia , Carcinoma Pulmonar de Células não Pequenas/patologia , Neoplasias Pulmonares/patologia , Fator de Crescimento Transformador beta1/metabolismo , Adenocarcinoma/metabolismo , Adenocarcinoma Bronquioloalveolar/metabolismo , Idoso , Biomarcadores Tumorais/metabolismo , Carcinoma Pulmonar de Células não Pequenas/metabolismo , Feminino , Humanos , Técnicas Imunoenzimáticas , Neoplasias Pulmonares/metabolismo , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Micrometástase de Neoplasia , Estadiamento de Neoplasias , Prognóstico
5.
Anticancer Res ; 24(6): 4073-7, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15736454

RESUMO

Carcinoid tumors are recognized as a low-grade malignancy. Recurrence of bronchopulmonary typical carcinoids is extremely rare. We herein report a case of recurrent multiple intraluminal bronchial typical carcinoids that were successfully removed using argon plasma coagulation by bronchoscopic approach. A 48-year-old man, who had undergone resection of a pulmonary typical carcinoid 8 years previously, suffered from a productive cough and hemosputum for a month. Bronchoscopic examination revealed multiple intraluminal bronchial polypoid tumors. Based on histopathological findings, we diagnosed recurrence of typical carcinoids. The patient underwent argon plasma coagulation (APC) treatment by bronchoscopic approach several times. APC treatment is considered to be a safer method than conventional bronchoscopic treatment with neodymium-yttrium aluminum garnet (Nd-YAG) laser or electrocautery. After a series of treatments, his symptoms completely improved and no recurrence was found during 10 months of follow-up.


Assuntos
Tumor Carcinoide/cirurgia , Eletrocoagulação/métodos , Neoplasias Pulmonares/cirurgia , Argônio , Broncoscopia/métodos , Humanos , Masculino , Pessoa de Meia-Idade
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