[Decision on the immunomodulating therapy in unspecific osteomyelitis of the spine].

Immunomodulating therapy was used in treatment of 54 patients with unspecific osteomyelitis of the spine (UOS). The age of the patients was from 15 through 76 years. The authors consider that immunocorrection should be included in the complex of obligatory measures of treatment of patients with purulent infections of the spine and is dependent on the type of immunological impairments. For its success it is necessary to determine the type and degree of immunity impairment. Since in most cases of UOS there is a disorder in the T-cell link of immunity, it is preferable to use cytomedins (T-activin, thymalin, thymogen etc) or cytokines (e.g. roncoleukin). In cases of an insufficient B-cell link the medicines of choice are licopid and myelopid.

[Assessment of the immuological status in patients with nonspecific spinal osteomyelitis]. / K voprosu ob otsenke immunologicheskogo statusa u bol'nykh s nespetsificheskim osteomielitom pozvonochnika.

The authors describe results of the investigation of the immunological status of 54 patients with nonspecific osteomyelitis of the spine (NOS). The immunological status of NOS patients was shown to be substantially different in the acute and chronic phases of the disease. Cases with lower T-lymphocyte activity, with a dysfunction of the phagocytic activity of lymphocytes prevail in the acute phase. Patients with septic forms of NOS have a hyperergic systemic inflammatory response which is accompanied by functional defectiveness of T-lymphocytes and excessive stimulation of the humoral link. Patients with the chronic form of NOS as a rule have hypoergic systemic inflammatory response with the normal quantity of T-cells, non-completed phagocytosis and high activity of B-lymphocytes (CD20, CD25). So, the early immunological diagnosis of NOS allows prognosis of the disease course and a timely decision for the pathogenetical therapy.

[The current principles of the intensive therapy of the suppurative-septic complications after a cesarean section operation]. / Sovremennye printsipy intensivnoi terapii gnoino-septicheskikh oslozhnenii posle operatsii kesareva secheniia.

The results of treatment of 25 patients with septic complications after cesarean section are analyzed. Clinical and laboratory data demonstrate the efficiency of combined therapy including intraosseous injections of antibiotics, plasmapheresis, and UV blood exposure.

[Efferent methods in the therapy of puerperal and postoperative complications]. / Efferentnye metody terapii poslerodovykh i posleoperatsionnykh oslozhnenii.

Ninety-six patients with chorioamnionitis in labor were treated. Clinical observations and laboratory findings demonstrated high efficiency of multiple-modality treatment including use of efferent methods: plasmapheresis, incubation of cell mass with antibiotics, and ultra-violet exposure of the blood.

[Clinico-immunological research on patients with different forms of amyotrophic lateral sclerosis]. / Kliniko-immunologicheskie issledovaniia bol'nykh s raznymi formami bokovogo amiotroficheskogo skleroza.

Changes in the immunological status of patients with lateral amyotrophic sclerosis (LAS) point to the involvement of the autoimmune component into the disease pathogenesis. At the same time there is a correlation between the intensity of immunological disorders and the age, disease pattern and the rate of the pathological process generalization. The lowering of immunological functions is noted to decline with age, possibly leading to the rise of the LAS incidence in older persons.

[Functional activity of the natural killers and macrophages in patients with breast tumors]. / Funktsional'naia aktivnost' estestvennykh killerov i makrofagov u bol'nykh pri opukholiakh molochnoi zhelezy.

The activity of natural killers (NK) and macrophages of peripheral blood was studied in 37 female donors, 40 patients with benign and 43 with malignant tumors of the breast of various stages prior to treatment. Also the effect of Soviet-made recombinant interleukin-2 on NK activity was assessed. Natural killer activity (cytotoxic index) was 34.1 +/- 1.42 in healthy donors, 44.2 +/- 3.64 in cases of fibroadenomatosis, 43.1 +/- 5.6 in patients with stages I-IIa, 64.4 +/- 3.93--stage IIb, 45.8 +/- 6.32--stage III and 16.6 +/- 7.21% in cases of stage IV breast cancer, the scatter of values being greater in the tumor group. As many as 40% of patients with stages I-IIa and III cancer showed increased NK-activity values. An in vitro stimulating effect of NK activity of peripheral blood mononuclear cells by Soviet-made recombinant interleukin-2 was established.

[Effect of maternal milk antibodies on the immune response of the progeny]. / Vliianie antitel materinskogo moloka na immunologicheskii otvet potomstva

The influence of antibodies transmitted with milk on the progeny's immune response was studied. Mice were injected with sheep erythrocytes during the last trimester of gestation. The newborns from the immunized and nonimmunized mothers were exhanged on the first day. Hemagglutinins were shown to be transmitted with milk during the whole suckling period and decreased the plaque-forming immune response of the suckling mice.