Assuntos
Gota/diagnóstico , Programas de Rastreamento/métodos , Adolescente , Adulto , Idoso , Diagnóstico Diferencial , Feminino , Gota/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , U.R.S.S.RESUMO
The authors describe the results of HLA-DR typing of 80 patients with rheumatoid arthritis (RA). The patients showed accumulation of HIA-DR (51.25% versus 28.9% in the control), with the relative risk being 2.58. The interrelationship is demonstrated between the clinical picture of RA and HIA-DR antigens: a statistically significant accumulation of HIA-DR4 in the seropositive patterns according to the RF of RA as compared with the seronegative pattern and primary demonstration of HIA-DR3 in RA with the systemic manifestations as compared with the articular pattern.
Assuntos
Artrite Reumatoide/imunologia , Antígenos de Histocompatibilidade Classe II/análise , Adolescente , Adulto , Idoso , Artrite Reumatoide/genética , Suscetibilidade a Doenças , Genes MHC da Classe II , Antígenos HLA-DR , Antígenos de Histocompatibilidade Classe II/genética , Humanos , Pessoa de Meia-IdadeAssuntos
Osteoartrite/diagnóstico , Adulto , Diagnóstico Diferencial , Erros de Diagnóstico , Feminino , Humanos , Masculino , Métodos , Pessoa de Meia-IdadeAssuntos
Etnicidade , Artropatias/epidemiologia , Adolescente , Adulto , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , SibériaAssuntos
Artrite Reumatoide/genética , Antígenos HLA/genética , Adulto , Artrite Reumatoide/imunologia , Humanos , Fenótipo , RiscoRESUMO
The results of medical-genetic examination of population in five villages of Taimir have been presented. Among them 824 dolgans (aborigines) have been inspected. The prevalence of rheumatism is in average 3,23%. The frequency of rheumatism in the southern subpopulation was higher, than in the North. Analysis of pedigrees has shown family aggregation of rheumatism which correlated with theoretically expected according to recessive hypothesis. Investigations of genetic markers have shown important distinction of rheumatic patients from population on ABC and Hp.
Assuntos
Etnicidade , Genética Populacional , Doenças Reumáticas/genética , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Frequência do Gene , Marcadores Genéticos , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Fenótipo , Doenças Reumáticas/epidemiologia , População Rural , Sibéria , Fatores SocioeconômicosAssuntos
Artrite Reumatoide/genética , Adolescente , Adulto , Idoso , Artrite/genética , Criança , Feminino , Genes , Humanos , Masculino , Pessoa de Meia-Idade , Moscou , Doenças Reumáticas/genética , Federação RussaRESUMO
With a view to establishing standardized criteria for the diagnosis of rheumatism suitable for widespread use in polyclinics and in large-scale epidemiological investigations, 3000 adults and children with rheumatism or one of seven similar diseases were subjected to multiple screening in eight centres in the USSR using a specially prepared standard card and standard methods. The information obtained was processed by cybernetic methods. Following determination of the sensitivity, specificity, and informational value of 486 signs of rheumatism, 68 of the most indicative signs were selected as criteria of rheumatism. These were included in the final table and weighted according to their indicational value both individually and in groups as syndromes. Using the table it is possible by simple calculation, without using a computer, to arrive at an objective evaluation of the reliability of the clinical diagnosis of rheumatism in patients with one of a group of eight similar diseases. The final diagnostic table was tested on 562 patients selected epidemiologically or from polyclinics or clinics and was shown to result in a high degree of diagnostic precision (higher than 95%).
