[Diagnosis of the causes and prevention of intrauterine fetal death in the second trimester of pregnancy in women with hyperandrogenism]. / Diagnostika prichin i profilaktika vnutriutrobnoi gibeli ploda vo II trimestre beremennosti u zhenshchin s giperandrogeniei.

Differential diagnosis of the causes of intrauterine fetal death was carried out in 84 women; in 57 of them it was due to hyperandrogenism of various origins. 63.2% of patients suffered from mixed (combined ++ovario-adrenal) androgen hypersecretion, 33.3% from the adrenal and only 3.5% of women from the ovarian form of hyperandrogenism. Relationship between the frequency of intrauterine fetal death, the pregnancy term and the form of hyperandrogenism was revealed. Differential diagnosis of hyperandrogenism forms and preparatory pathogenetic therapy helped preserve the pregnancy and resulted in delivery of a viable healthy child in 77.4% of the examined women.

[Breast diseases in patients with hyperandrogenism]. / Mastopatiia u bol'nykh s giperandrogeniei.

The study has been undertaken in 40 women with excessive androgen levels in the age range of 22 to 38 years. Various types of mastopathy were found in 34 and fatty degeneration of the glandular tissue in 6 women. On the basis of clinical and laboratory studies, the patients were assigned to 3 groups: ovarian hyperandrogenism, adrenal and ovarian-adrenal hyperandrogenism. Breast hyperplasia was seen in all groups, but adenofibrosis occurred in groups I and III at a 2-2.5-fold higher rate as compared with group II. The patients with hyperandrogenism, anovulation, increased body mass index, low hirsute number and polycystic ovaries were at the highest risk of dyshormonal mammary hyperplasia. An adequate therapeutic approach was suggested for mastopathies in hyperandrogenic patients.

[Polycystic ovary syndrome with excess of prolactin]. / Sindrom polikistoznykh iaichnikov s povyshenniem urovnem prolaktina.

Therapy including parlodel, dexamethasone, clomiphene, norcolut and various combinations of these has been used in order to restore reproductive function of patients with polycystic ovary syndrome and hyperprolactinemia. Pregnancy was induced in 42.3% of the patients, with drug combinations employed in most cases. Application of one of the agents alone was inefficient.

[The importance of rehabilitation therapy for the outcome of a subsequent pregnancy in women with spontaneous abortion and hyperandrogenism]. / Znachenie reabilitatsionnoi terapii dlia iskhoda posleduiushchei beremennosti u zhenshchin s nevynashivaniem i giperandrogeniei.

A complex clinical-hormonal examination was conducted in 140 women most of whom suffered from habitual abortion and hyperandrogenicity (HA). Based on the clinical findings, determination of the basal hormone level, and functional tests the patients were divided into 3 groups: 1) patients with predominantly adrenal HA (30 per cent); 2) patients with mainly ovarian HA (12.1 per cent), and 3) patients with an abnormally high level of androgens of ovarian-adrenal origin (57.9 per cent). The peculiarities of the clinical and hormonal parameters in patients of the three groups as well as the pathogenetic therapy aimed at preparation for pregnancy prolongation to term and birth of a viable neonate.

[State of the reproductive function in women with hyperandrogenism and miscarriage in the immediate period and long-term follow-up]. / Sostoianie reproduktivnoi funktsii u zhenshchin s giperandrogeniei i nevynashivaniem beremennosti v blizhaishie i otdalennye sroki nabliudeniia.

A study was made of 180 females aged 22-58 years with a history of premature labor secondary to high levels of androgen. The ovarian pattern of the disease was stated in 21 per cent (group I), mixed in 49 per cent (group II) and adrenal, in 30 per cent of examinee s (group III). In 69.4 per cent, the pregnancy ended in the delivery of a viable fetus. Recovery of reproductive function was a failure in 30.6 per cent of the patients (group II mainly). Longitudinal study revealed the dependence of menstrual and generative functions both on the disease pattern and outcome of the previous pregnancy. The most unfavourable prognosis for the further progression of reproductive dysfunction was made for females with ovarian or mixed patterns of the disease therefore they might be considered as a risk-group.