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1.
Hippocampus ; 32(10): 752-764, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36018284

RESUMO

Retrosplenial cortex (RSC) is a brain region involved in critical cognitive functions including memory, planning, and spatial navigation and is commonly affected in neurodegenerative diseases. Subregions of RSC are typically described as Brodmann areas 29 and 30, which are defined by cytoarchitectural features. Using immunofluorescence, we studied the distributions of neurons immunoreactive for NeuN, latexin, and calcium binding proteins (calbindin, calretinin, and parvalbumin) in RSC of Carollia perspicillata, Seba's short-tailed fruit bat. We observed that latexin was specifically present in areas 29a and 29b but not 29c and 30. We further identified distribution patterns of calcium binding proteins that group areas 29a and 29b separately from areas 29c and 30. We conclude first that latexin is a useful marker to classify subregions of RSC and second that these subregions contain distinct patterns of neuronal immunoreactivity for calcium binding proteins. Given the long lifespan of Carollia, bat RSC may be a useful model in studying age-related neurodegeneration.


Assuntos
Quirópteros , Animais , Calbindina 2/metabolismo , Calbindinas/metabolismo , Proteínas de Ligação ao Cálcio/metabolismo , Quirópteros/fisiologia , Giro do Cíngulo , Parvalbuminas/metabolismo
2.
Brain Struct Funct ; 227(5): 1615-1640, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35188589

RESUMO

Few brain regions have such wide-ranging inputs and outputs as the claustrum does, and fewer have posed equivalent challenges in defining their structural boundaries. We studied the distributions of three calcium-binding proteins-calretinin, parvalbumin, and calbindin-in the claustrum and dorsal endopiriform nucleus of the fruit bat, Carollia perspicillata. The proportionately large sizes of claustrum and dorsal endopiriform nucleus in Carollia brain afford unique access to these structures' intrinsic anatomy. Latexin immunoreactivity permits a separation of claustrum into core and shell subregions and an equivalent separation of dorsal endopiriform nucleus. Using latexin labeling, we found that the claustral shell in Carollia brain can be further subdivided into at least four distinct subregions. Calretinin and parvalbumin immunoreactivity reinforced the boundaries of the claustral core and its shell subregions with diametrically opposite distribution patterns. Calretinin, parvalbumin, and calbindin all colocalized with GAD67, indicating that these proteins label inhibitory neurons in both claustrum and dorsal endopiriform nucleus. Calretinin, however, also colocalized with latexin in a subset of neurons. Confocal microscopy revealed appositions that suggest synaptic contacts between cells labeled for each of the three calcium-binding proteins and latexin-immunoreactive somata in claustrum and dorsal endopiriform nucleus. Our results indicate significant subregional differences in the intrinsic inhibitory connectivity within and between claustrum and dorsal endopiriform nucleus. We conclude that the claustrum is structurally more complex than previously appreciated and that claustral and dorsal endopiriform nucleus subregions are differentially modulated by multiple inhibitory systems. These findings can also account for the excitability differences between claustrum and dorsal endopiriform nucleus described previously.


Assuntos
Quirópteros , Claustrum , Animais , Gânglios da Base/fisiologia , Calbindina 2/metabolismo , Calbindinas/metabolismo , Proteínas de Ligação ao Cálcio/metabolismo , Neurônios/metabolismo , Parvalbuminas/metabolismo , Proteína G de Ligação ao Cálcio S100/metabolismo
3.
Biomedicines ; 9(10)2021 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-34680571

RESUMO

As the average human lifespan lengthens, the impact of neurodegenerative disease increases, both on the individual suffering neurodegeneration and on the community that supports those individuals. Studies aimed at understanding the mechanisms of neurodegeneration have relied heavily on observational studies of humans and experimental studies in animals, such as mice, in which aspects of brain structure and function can be manipulated to target mechanistic steps. An animal model whose brain is structurally closer to the human brain, that lives much longer than rodents, and whose husbandry is practical may be valuable for mechanistic studies that cannot readily be conducted in rodents. To demonstrate that the long-lived Seba's short-tailed fruit bat, Carollia perspicillata, may fit this role, we used immunohistochemical labeling for NeuN and three calcium-binding proteins, calretinin, parvalbumin, and calbindin, to define hippocampal formation anatomy. Our findings demonstrate patterns of principal neuron organization that resemble primate and human hippocampal formation and patterns of calcium-binding protein distribution that help to define subregional boundaries. Importantly, we present evidence for a clear prosubiculum in the bat brain that resembles primate prosubiculum. Based on the similarities between bat and human hippocampal formation anatomy, we suggest that Carollia has unique advantages for the study of brain aging and neurodegeneration. A captive colony of Carollia allows age tracking, diet and environment control, pharmacological manipulation, and access to behavioral, physiological, anatomical, and molecular evaluation.

4.
Front Neurol ; 11: 326, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32390935

RESUMO

Field potential oscillations reflect repetitive firing and synaptic activity by ensembles of neurons in certain areas of the brain. They can be distinguished as slow (e.g., alpha, delta, and theta), fast (e.g., beta and gamma), and high frequency oscillations (HFOs). Neuronal oscillations are involved in a variety of physiological and pathophysiological states such as cognition, consciousness, and seizures. The laminar structure of rat hippocampus affords a way to study these oscillations in hippocampal slices. Rat ventral hippocampal brain slices were cut and maintained in a recording chamber that permitted 64 simultaneous extracellular recordings in the presence of artificial CSF. Brief single stimulus pulses were applied with bipolar electrodes to the CA3 or CA1 regions of hippocampus. Single pulses triggered epileptiform population events that included HFOs in the 150-250 Hz range in the presence of GABAA receptor blockade or kainic acid. HFOs also occurred spontaneously in the presence of kainic acid. The oscillations had the largest amplitude in the CA3c cell layer, regardless of the drug, and were synchronized throughout the cell layer. AMPA receptor blockade stopped these HFOs, whereas NMDA receptor blockade did not. Gap junction activation did not restore HFOs in the presence of AMPA receptor blockade. Our findings suggest that a population of excitatory neurons in CA3c may be a primary focus of seizure-like activity in Ammon's Horn. We suggest that the interconnection of CA3c is different from the rest of CA3.

5.
J Comp Neurol ; 527(2): 476-499, 2019 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-30225888

RESUMO

With the emergence of interest in studying the claustrum, a recent special issue of the Journal of Comparative Neurology dedicated to the claustrum (Volume 525, Issue 6, pp. 1313-1513) brought to light questions concerning the relationship between the claustrum (CLA) and a region immediately ventral known as the endopiriform nucleus (En). These structures have been identified as separate entities in rodents but appear as a single continuous structure in primates. During the recent Society for Claustrum Research meeting, a panel of experts presented data pertaining to the relationship of these regions and held a discussion on whether the CLA and En should be considered (a) separate unrelated structures, (b) separate nuclei within the same formation, or (c) subregions of a continuous structure. This review article summarizes that discussion, presenting comparisons of the cytoarchitecture, neurochemical profiles, genetic markers, and anatomical connectivity of the CLA and En across several mammalian species. In rodents, we conclude that the CLA and the dorsal endopiriform nucleus (DEn) are subregions of a larger complex, which likely performs analogous computations and exert similar effects on their respective cortical targets (e.g., sensorimotor versus limbic). Moving forward, we recommend that the field retain the nomenclature currently employed for this region but should continue to examine the delineation of these structures across different species. Using thorough descriptions of a variety of anatomical features, this review offers a clear definition of the CLA and En in rodents, which provides a framework for identifying homologous structures in primates.


Assuntos
Claustrum/anatomia & histologia , Animais , Claustrum/crescimento & desenvolvimento , Claustrum/metabolismo , Humanos , Primatas , Roedores , Terminologia como Assunto
6.
Epilepsia ; 58(6): e87-e90, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-28464295

RESUMO

Seizure spread into autonomic and respiratory brainstem regions is thought to play an important role in sudden unexpected death in epilepsy (SUDEP). As the clinical dataset of cases of definite SUDEP available for study grows, evidence points to a sequence of events that includes postictal apnea, bradycardia, and asystole as critical events that can lead to death. One possible link between the precipitating seizure and the critical postictal sequence is seizure-driven laryngospasm sufficient to completely obstruct the airway for an extended period, but ictal laryngospasm is difficult to fully assess. Herein, we demonstrate in a rat model how the electrical artifacts of attempts to inspire during airway obstruction and features of the cardiac rhythm establish this link between ictal and postictal activity and can be used as practical biomarkers of obstructive apnea due to laryngospasm or other causes of airway obstruction.


Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Biomarcadores , Tronco Encefálico/fisiopatologia , Morte Súbita/etiologia , Morte Súbita/prevenção & controle , Modelos Animais de Doenças , Eletrocardiografia , Eletromiografia , Epilepsia/complicações , Epilepsia/fisiopatologia , Laringismo/complicações , Laringismo/fisiopatologia , Centro Respiratório/fisiopatologia , Processamento de Sinais Assistido por Computador , Apneia Obstrutiva do Sono/complicações , Apneia Obstrutiva do Sono/fisiopatologia , Animais , Masculino , Ratos Sprague-Dawley , Fatores de Risco , Convulsões/complicações , Convulsões/fisiopatologia , Trabalho Respiratório
7.
J Comp Neurol ; 525(6): 1459-1474, 2017 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-28206685

RESUMO

The claustrum is a gray-matter structure that underlies neocortex and reciprocates connections with cortical and subcortical targets. In lower mammals, the claustrum is directly adjacent to neocortex, making the definition of claustral boundaries challenging. Latexin, an endogenous inhibitor of metallocarboxypeptidases, localizes to claustral cells, enabling a clear delineation of claustrum. Given its proportionately large claustrum, we hypothesized that the short-tailed fruit bat, Carollia perspicillata, can be a useful model for claustral structure-function relations. We used latexin immunohistochemistry to identify claustral boundaries and intrinsic structure and multielectrode recordings from brain slices to explore intrinsic excitatory connectivity of the claustrum. Carollia's claustrum contains cells whose intrinsic connectivity and alignment permit the generation of spontaneous, synchronous population events and mirror their pattern of spread in disinhibited brain slices over millimeters. Carollia shows cellular alignment and spontaneous population-activity spread along both horizontal and dorsoventral axes. Carollia claustrum possesses intrinsic excitatory connectivity sufficient to: 1) generate single, spontaneous, synchronized burst discharges, 2) support activity spread along axes where claustral cells are aligned, and 3), because of multiple axes for cell alignment, support activity spread along both rostrocaudal and dorsoventral axes. The smaller event sizes in bat claustrum compared with rat claustrum are consistent with events occurring in population subsets rather than the full claustral cell population. The overall size of claustrum, its pronounced vascularity, and its more complex intrinsic connectivity than rat suggest that the bat is an animal model for claustral structure and function that will permit unique access to claustrum's processing capabilities. J. Comp. Neurol. 525:1459-1474, 2017. © 2016 Wiley Periodicals, Inc.


Assuntos
Gânglios da Base/anatomia & histologia , Quirópteros/anatomia & histologia , Vias Neurais/citologia , Animais , Gânglios da Base/fisiologia , Quirópteros/fisiologia , Eletrofisiologia , Feminino , Imuno-Histoquímica , Masculino , Vias Neurais/fisiologia
8.
J Physiol Sci ; 65(6): 533-44, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26329935

RESUMO

Claustrum, a gray matter structure that underlies the neocortex, is reciprocally connected with many neocortical and limbic cortical areas. This connectivity positions claustrum ideally for the integration or coordination of widespread cortical activity. In anatomical studies using multiple planes of section, claustrum has distinct subregions based on latexin immunohistochemistry, and an approximately rostro-caudal alignment of fusiform cells supporting a laminar intrinsic organization. Physiological studies of claustral connectivity in disinhibited brain slices demonstrate (1) intrinsic connectivity sufficient to generate spontaneous synchronized burst discharges, (2) activity spread within the oblique laminae that contained the principal cellular axis, and (3) segregation of activity as evidenced by the absence of spread within coronal planes. Activity spread depended on glutamatergic synaptic transmission, and activity restrictions did not depend on inhibitory circuits. We conclude that the claustrum has an intrinsic excitatory connectivity that is constrained in approximately rostro-caudal laminae, with minimal cross-communication between laminae. Further, claustrum has the intrinsic capability of generating synchronized population activity and facilitating its spread within laminae, a feature that may contribute to seizure generation and spread.


Assuntos
Gânglios da Base/citologia , Gânglios da Base/fisiologia , Comunicação Celular/fisiologia , Neurônios/fisiologia , 6-Ciano-7-nitroquinoxalina-2,3-diona/farmacologia , Animais , Antígenos , Bicuculina/farmacologia , Cálcio/farmacologia , Fenômenos Eletrofisiológicos , Antagonistas de Aminoácidos Excitatórios/administração & dosagem , Antagonistas de Aminoácidos Excitatórios/farmacologia , Antagonistas de Receptores de GABA-A/administração & dosagem , Antagonistas de Receptores de GABA-A/farmacologia , Imuno-Histoquímica , Masculino , Ratos , Ratos Sprague-Dawley , Transdução de Sinais/efeitos dos fármacos , Transdução de Sinais/fisiologia
9.
Epilepsy Res ; 108(1): 44-56, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24286892

RESUMO

Cardiac autonomic, conduction, and structural changes may occur in epilepsy and may contribute to sudden unexpected death in epilepsy (SUDEP), e.g. by increasing the risk for ventricular fibrillation (VF). In a model of chronic seizures in rats, we sought to study (1) cardiac and autonomic derangements that accompany the epileptic state, (2) whether chronically seizing rats experienced more significant cardiac effects after severe acute seizures, and (3) the susceptibility of chronically seizing rats to VF arising from autonomic and hypoxemic changes, which commonly occur during seizures. Sprague-Dawely rats were injected with saline or kainic acid to induce chronic seizures. At 2-3 months or 7-11 months after injection, these rats were studied with both 12-lead electrocardiography (to assess heart rate variability and QT dispersion) and echocardiography under ketamine/xylazine or urethane anesthesia. Hearts were subsequently excised, weighed, and examined histologically. Epileptic rats exhibited decreased vagal tone, increased QT dispersion, and eccentric cardiac hypertrophy without significant cardiac fibrosis, especially at 7-11 months post-injection. Of these three findings, vagal tone was inversely correlated with heart weights. Epileptic rats exhibited diminished systolic function compared to controls after severe acute seizures. However, animals with long-standing chronic seizures were less susceptible to autonomic/hypoxemia-driven VF, and their susceptibility inversely correlated with mean left ventricular wall thickness on histology. On the basis of this model, we conclude that cardiac changes accompany epilepsy and these can lead to significant seizure-associated cardiac performance decreases, but these cardiac changes actually lower the probability of VF.


Assuntos
Sistema Nervoso Autônomo/fisiologia , Cardiomegalia/patologia , Modelos Animais de Doenças , Epilepsia/patologia , Fibrilação Ventricular/patologia , Animais , Cardiomegalia/complicações , Cardiomegalia/fisiopatologia , Epilepsia/complicações , Epilepsia/fisiopatologia , Frequência Cardíaca/fisiologia , Masculino , Ratos , Ratos Sprague-Dawley , Nervo Vago/fisiologia , Fibrilação Ventricular/complicações , Fibrilação Ventricular/fisiopatologia
10.
Auton Neurosci ; 156(1-2): 144-8, 2010 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-20510656

RESUMO

Autonomic dysfunction during seizures can induce bradyarrhythmia via efferent vagal overactivity. We studied cardiovascular, brain blood flow, and electroencephalographic consequences of vagal stimulation during seizures in rats. Efferent vagal stimulation reduced seizure activity, completely suppressing it at high frequencies, by reducing heart rate, arterial pressure, and cortical blood flow. Afferent vagal activation was more variable, and the highest stimulation frequencies also appeared to reduce cortical blood flow. We conclude that efferent vagal activity can arrest ongoing seizure activity by ultimately decreasing hippocampal blood flow. Afferent vagal activity (which does not occur during seizures) may have a similar action.


Assuntos
Córtex Cerebral/fisiologia , Circulação Cerebrovascular/fisiologia , Neurônios Aferentes/fisiologia , Neurônios Eferentes/fisiologia , Convulsões/fisiopatologia , Nervo Vago/fisiologia , Animais , Velocidade do Fluxo Sanguíneo/efeitos dos fármacos , Velocidade do Fluxo Sanguíneo/fisiologia , Córtex Cerebral/irrigação sanguínea , Córtex Cerebral/efeitos dos fármacos , Circulação Cerebrovascular/efeitos dos fármacos , Ácido Caínico/toxicidade , Masculino , Neurônios Aferentes/efeitos dos fármacos , Neurônios Eferentes/efeitos dos fármacos , Ratos , Ratos Wistar , Convulsões/induzido quimicamente , Uretana/farmacologia , Nervo Vago/efeitos dos fármacos
11.
Auton Neurosci ; 151(2): 98-105, 2009 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-19651541

RESUMO

The autonomic consequences of seizures can be severe. Death can follow from autonomic overactivity that causes a parasympathetically mediated bradyarrhythmia. We studied the cardiovascular consequences of unilateral and bilateral stimulation of the distal segments of transected vagus nerve in rats anesthetized with urethane. The range of stimulation rates tested is comparable to the firing rates observed in vagus nerve during seizures. There was a consistent inverse relation between stimulus rate and heart rate with nodal block appearing at 5-10 Hz and minimum HR levels (cardiac standstill) occurring at 50 Hz. Cardiac standstill could last many seconds. Blood pressure during VNS was maintained during lower frequency VNS, but collapsed at frequencies > or =20 Hz to dramatically impair ventricular filling. Recovery of heart rate and blood pressure after VNS was rapid. In the presence of sympathetic co-activation (pharmacological or hypercapnia and/or hypoxia), mean arterial pressure was better maintained and there was much better ventricular filling, but cardiac performance was worse (e.g. ejection fraction derived from echocardiography). The combination of sympathetic and parasympathetic overactivity was sometimes associated with prolonged (> or =20 s) apneic periods during VNS. We conclude that an abrupt increase in parasympathetic activity on the order of 5 times the background of parasympathetic tone can produce transient bradyarrhythmias, and increases on the order of 20 times can produce cardiac standstill, sometimes accompanied by apnea. Our findings suggest that parasympathetically mediated bradyarrhythmia must be accompanied by airway obstruction to sustain parasympathetic overactivity and produce hypoxia to ultimately cause death.


Assuntos
Doenças do Sistema Nervoso Autônomo/fisiopatologia , Bradicardia/fisiopatologia , Epilepsia/fisiopatologia , Sistema Nervoso Parassimpático/fisiopatologia , Doenças do Nervo Vago/fisiopatologia , Animais , Apneia/etiologia , Apneia/fisiopatologia , Doenças do Sistema Nervoso Autônomo/etiologia , Pressão Sanguínea/fisiologia , Bradicardia/etiologia , Morte Súbita Cardíaca/etiologia , Modelos Animais de Doenças , Epilepsia/complicações , Coração/inervação , Coração/fisiopatologia , Sistema de Condução Cardíaco/fisiopatologia , Frequência Cardíaca/fisiologia , Masculino , Ratos , Ratos Wistar , Volume Sistólico/fisiologia , Sistema Nervoso Simpático/fisiopatologia , Nervo Vago/fisiopatologia , Doenças do Nervo Vago/etiologia , Estimulação do Nervo Vago/efeitos adversos
12.
Perception ; 37(3): 401-7, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18491717

RESUMO

Synfire chains have long been suggested as a substrate for perception and information processing in the nervous system. However, embedding activation chains in a densely connected nervous matrix risks spread of signal that will obscure or obliterate the message. We used computer modeling and physiological measurements in rat hippocampus to assess this problem of activity broadening. We simulated a series of neural modules with feedforward propagation and random connectivity within each module and from one module to the next. We found that activity broadened as it propagated from one module to the next. This occurred over a wide array of parameters with greater broadening seen with increasing excitatory-excitatory synaptic strength. Activity broadening correlated positively with propagation velocity. Multi-electrode measurements of activity propagation in disinhibited CA1 slice demonstrated broadening of about 50% over 1 mm. Such broadening is a problem for information transfer that must be dealt with in a fully functioning nervous system.


Assuntos
Simulação por Computador , Modelos Neurológicos , Neurônios/fisiologia , Percepção/fisiologia , Animais , Bicuculina/farmacologia , Estimulação Elétrica , Antagonistas GABAérgicos/farmacologia , Masculino , Microeletrodos , Vias Neurais/efeitos dos fármacos , Vias Neurais/fisiologia , Neurônios/efeitos dos fármacos , Técnicas de Cultura de Órgãos , Ratos , Ratos Sprague-Dawley
13.
Epilepsia ; 49(6): 982-96, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18325014

RESUMO

PURPOSE: Autonomic consequences of seizures are common, but can be severe. We sought to define changes in autonomic activity from limbic cortical seizures and their impact on the heart. METHODS: We studied kainic acid (KA)-induced seizures in urethane-anesthetized rats using peripheral nerve, blood pressure (BP), and ECG recordings and echocardiography. RESULTS: Seizures were associated with massive increases in parasympathetic (vagus nerves) and sympathetic (cervical sympathetic ganglion >renal nerve >splanchnic nerve) activity. Seizure-associated activity increases were greater than activity changes induced by nitroprusside or phenylephrine (each producing BP changes of >50 mmHg). Increases in c-fos expression were found in both sympathetic and parasympathetic medullary regions (as well as hypothalamic areas). Baroreceptor reflex function (tested with nitroprusside and phenylephrine) was impaired during seizures. Finally, a significant fraction of the animals died and the mechanism of death was defined through ECG, BP, and echocardiographic measures to be profound cardiac dilatation and bradyarrhythmia leading to hypoperfusion of the brain and ultimately hypoperfusion of the heart. Cardiovascular changes occur within seconds (or less) of autonomic nerve activity changes and death by these mechanisms takes minutes. DISCUSSION: We propose that the massive parasympathetic and sympathetic outflow that occurs during a seizure gets compounded by respiratory distress (driving both autonomic nervous system divisions in the same direction) causing mechanical dysfunction, slowing the heart, and hypoperfusing the brain.


Assuntos
Sistema Nervoso Autônomo/efeitos dos fármacos , Córtex Cerebral/efeitos dos fármacos , Epilepsia/induzido quimicamente , Agonistas de Aminoácidos Excitatórios/toxicidade , Coração/inervação , Ácido Caínico/toxicidade , Sistema Límbico/efeitos dos fármacos , Animais , Sistema Nervoso Autônomo/patologia , Sistema Nervoso Autônomo/fisiopatologia , Barorreflexo/efeitos dos fármacos , Pressão Sanguínea/efeitos dos fármacos , Isquemia Encefálica/induzido quimicamente , Isquemia Encefálica/patologia , Isquemia Encefálica/fisiopatologia , Baixo Débito Cardíaco/induzido quimicamente , Baixo Débito Cardíaco/patologia , Baixo Débito Cardíaco/fisiopatologia , Córtex Cerebral/patologia , Córtex Cerebral/fisiopatologia , Ecocardiografia/efeitos dos fármacos , Eletrocardiografia/efeitos dos fármacos , Eletroencefalografia/efeitos dos fármacos , Epilepsia/patologia , Epilepsia/fisiopatologia , Frequência Cardíaca/efeitos dos fármacos , Hipotálamo/efeitos dos fármacos , Hipotálamo/patologia , Sistema Límbico/patologia , Sistema Límbico/fisiopatologia , Masculino , Bulbo/efeitos dos fármacos , Bulbo/patologia , Nitroprussiato/farmacologia , Nervos Periféricos/efeitos dos fármacos , Nervos Periféricos/fisiopatologia , Fenilefrina/farmacologia , Proteínas Proto-Oncogênicas c-fos/análise , Ratos , Ratos Sprague-Dawley , Sistema Nervoso Simpático/patologia , Sistema Nervoso Simpático/fisiopatologia
14.
Epilepsy Behav ; 7(3): 336-44, 2005 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16105749

RESUMO

Hippocampal area CA3 has been one of the most intensively studied brain regions for computer models of epileptiform activity. As physiological studies begin to extend outward to other hippocampal and parahippocampal areas, we must extend these models to understand more complex circuitry containing diverse elements. Study of subiculum is of particular interest in this context, as it is a structure of intermediate complexity, with an inchoate columnar and laminar organization. In addition to helping us understand seizures, modeling of these structures will also help us understand the genesis of physiological activity patterns that are below threshold for seizure generation. Such modeling can also serve as a basis for speculation regarding the nonictal behavioral consequences of epilepsy.


Assuntos
Comportamento/fisiologia , Simulação por Computador , Epilepsia/fisiopatologia , Epilepsia/psicologia , Convulsões/fisiopatologia , Convulsões/psicologia , Eletroencefalografia , Humanos
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