Neurological changes and emotional functioning in adults with Down Syndrome.

This study was designed to examine emotional changes in adults with Down Syndrome (DS) over time and whether changes in these psychological variables were associated with brain atrophy on MRI scan and the presence of pathological reflexes on the neurological examination. Participants were 26 adults with DS and their caregivers. Caregivers completed a measure of emotional functioning about individuals with DS at two different time points (1 year apart). Levels of cognitive functioning were measured and neurological and MRI examinations were performed on all subjects at initial testing. Significant group effect separated those with and without pathological findings on MRI and neurological exam across three different scales: depression, indifference, and pragmatic language functioning. Problems of poor pragmatic language functioning appeared later in the course of suspected Alzheimer's disease (AD), as demonstrated by a significant group effect at time 2, but not at initial testing. In these subjects, the primary emotional change was a decline in social discourse (e.g. conversational style, literal understanding, verbal expression in social contexts). These emotional levels were stable over time, regardless of degree of cognitive decline. Specific emotional changes occur during the course of AD which were associated with abnormal findings from MRI and from neurological examination. These results, along with abnormalities in brain imaging and the presence of pathological reflexes, suggested that frontal lobe dysfunction is likely to be an early manifestation of Alzheimer's Disease in Down Syndrome.

Premorbid IQ estimates from a multiple aptitude test battery: regression vs. equating.

Estimation of premorbid abilities remains an integral part of neuropsychological evaluations. Several methods of indirect estimation have been suggested in the literature. Many of these methods are based in prediction via linear regression. Unfortunately, linear regression has the well-reported tendency to underpredict high IQ scores and overpredict low IQ scores. This can be shown to be an unavoidable statistical artifact of linear regression. We demonstrate a procedure to estimate premorbid IQ without the regression artifact. The procedure has two steps: confirmation of construct equivalence and psychometric equating. An example using real data is presented which shows the regression to the mean problem with prediction and compares it to the results from equating.

The pre-intake drop-out at a community mental health center.

Characteristics of patients who failed to appear for their intake interviews at a community mental health center were contrasted with those who did follow through with their appointments. Findings suggest that characteristics associated with dropping out are likely to vary with patient groups. Show rates for adults who were seeking help for themselves were significantly related to parental status and the length of time from the day of scheduling an intake interview until that appointment. Patient-therapist gender matches were related to the probability of children showing for intake interviews.

Rorschach Erlebnistypus and problem-solving styles in children.

This study was designed to determine whether introversive versus extratensive children differed, on the basis of their Rorschach Erlebnistypus score, with respect to their approaches to three subtests (Block Design, Object Assembly, and Mazes) of the Wechsler Intelligence Scale for Children-Revised. It was thought that the extratensives would manipulate the test materials more and make more mistakes than the introversives, owing to the notion that introversives would internalize more of their manipulations and attempted solutions. Analysis of the data revealed mixed results.