RESUMO
UNLABELLED: A study is presented of 34 patients with rheumatoid arthritis. The authors propose a method of persistently maintained aurotherapy of patients with rheumatoid arthritis directed to prevention of recurrences and toxic effect of gold due to chrysanol treatment, the active substance of which is metallic gold. After course treatment with chrysanol (850-1020 mg) persistent treatment by maintained doses is instituted. RESULTS: prevention of recurrences of the disease and prevention of side effects due to the toxicity of cumulated gold.
Assuntos
Antirreumáticos/administração & dosagem , Artrite Reumatoide/tratamento farmacológico , Dimercaprol/análogos & derivados , Ouro/análise , Compostos Organometálicos/administração & dosagem , Antirreumáticos/efeitos adversos , Artrite Reumatoide/metabolismo , Artrite Reumatoide/prevenção & controle , Dimercaprol/administração & dosagem , Dimercaprol/efeitos adversos , Fezes/química , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Compostos Organoáuricos , Compostos Organometálicos/efeitos adversos , Propanóis , Recidiva , Compostos de Sulfidrila , Fatores de TempoRESUMO
The author studied the content of corticotropin, cortisol, aldosterone, insulin in the blood serum of 69 patients with rheumatoid arthritis depending on the grade of activity of the inflammatory process before treatment in the course of aurotherapy within 12 months. It was established that in patients with rheumatoid arthritis changes develop in the system of pituitary-peripheral endocrine glands, namely, an increase of the concentration of corticotropin, aldosterone and a reduction of the level of cortisol and insulin indicating the participation of hormones in the pathogenesis of rheumatoid arthritis. Non-steroid antiinflammatory preparations and quinolinic derivatives did not effect the hormonal spectrum of rheumatoid arthritis. Prolonged aurotherapy resulted in a positive dynamics in the contents of hormones.
Assuntos
Hormônio Adrenocorticotrópico/sangue , Aldosterona/sangue , Antirreumáticos/uso terapêutico , Artrite Reumatoide/tratamento farmacológico , Dimercaprol/uso terapêutico , Hidrocortisona/sangue , Insulina/sangue , Metaloproteínas/uso terapêutico , Compostos Organometálicos , Artrite Reumatoide/sangue , Avaliação de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , Masculino , Compostos Organoáuricos , Propanóis , Compostos de SulfidrilaAssuntos
Antirreumáticos/administração & dosagem , Artrite Reumatoide/tratamento farmacológico , Dimercaprol/análogos & derivados , Ouro/urina , Compostos Organometálicos/administração & dosagem , Artrite Reumatoide/urina , Doença Crônica , Dimercaprol/administração & dosagem , Fezes/química , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Compostos Organoáuricos , Propanóis , Compostos de Sulfidrila , Fatores de TempoRESUMO
To prevent side-effects of chrysotherapy for rheumatoid arthritis the authors recommend a treatment scheme under corticosteroid protection. The proposed method was used in 56 patients with rheumatoid arthritis. Side-effects manifested in allergic eruptions were noted in 3 patients (5.35%) while in the control group of 34 patients who were treated by chrysotherapy according to the routine method complications were observed in 9 patients (26.47%).