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1.
J Dent Res ; 102(11): 1180-1190, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37555431

RESUMO

Despite its reputation as the most widely used restorative dental material currently, resin-based materials have acknowledged shortcomings. As most systematic survival studies of resin composites and dental adhesives indicate, secondary caries is the foremost reason for resin-based restoration failure and life span reduction. In subjects with high caries risk, the microbial community dominated by acidogenic and acid-tolerant bacteria triggers acid-induced deterioration of the bonding interface and/or bulk material and mineral loss around the restorations. In addition, resin-based materials undergo biodegradation in the oral cavity. As a result, the past decades have seen exponential growth in developing restorative dental materials for antimicrobial applications addressing secondary caries prevention and progression. Currently, the main challenge of bioactive resin development is the identification of efficient and safe anticaries agents that are detrimental free to final material properties and show satisfactory long-term performance and favorable clinical translation. This review centers on the continuous efforts to formulate novel bioactive resins employing 1 or multiple agents to enhance the antibiofilm efficacy or achieve multiple functionalities, such as remineralization and antimicrobial activity antidegradation. We present a comprehensive synthesis of the constraints and challenges encountered in the formulation process, the clinical performance-related prerequisites, the materials' intended applicability, and the current advancements in clinical implementation. Moreover, we identify crucial vulnerabilities that arise during the development of dental materials, including particle aggregation, alterations in color, susceptibility to hydrolysis, and loss of physicomechanical core properties of the targeted materials.


Assuntos
Anti-Infecciosos , Cárie Dentária , Humanos , Restauração Dentária Permanente , Materiais Dentários , Resinas Compostas , Cárie Dentária/prevenção & controle , Odontologia
2.
Dent Mater ; 30(9): 1061-72, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24985539

RESUMO

UNLABELLED: The processes involved in placing resin composite restorations may degrade the fatigue strength of dentin and increase the likelihood of fractures in restored teeth. OBJECTIVE: The objective of this study was to evaluate the relative changes in strength and fatigue behavior of dentin caused by bur preparation, etching and resin bonding procedures using a 3-step system. METHODS: Specimens of dentin were prepared from the crowns of unrestored 3rd molars and subjected to either quasi-static or cyclic flexural loading to failure. Four treated groups were prepared including dentin beams subjected to a bur treatment only with a conventional straight-sided bur, or etching treatment only. An additional treated group received both bur and etching treatments, and the last was treated by bur treatment and etching, followed by application of a commercial resin adhesive. The control group consisted of "as sectioned" dentin specimens. RESULTS: Under quasi-static loading to failure there was no significant difference between the strength of the control group and treated groups. Dentin beams receiving only etching or bur cutting treatments exhibited fatigue strengths that were significantly lower (p≤0.0001) than the control; there was no significant difference in the fatigue resistance of these two groups. Similarly, the dentin receiving bur and etching treatments exhibited significantly lower (p≤0.0001) fatigue strength than that of the control, regardless of whether an adhesive was applied. SIGNIFICANCE: The individual steps involved in the placement of bonded resin composite restorations significantly decrease the fatigue strength of dentin, and application of a bonding agent does not increase the fatigue strength of dentin.


Assuntos
Condicionamento Ácido do Dente , Colagem Dentária , Dentina , Análise do Estresse Dentário , Humanos , Técnicas In Vitro
3.
Biomaterials ; 34(34): 8650-8659, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23948166

RESUMO

Composite restorations accumulate more biofilm than other dental materials. This increases the likelihood for the hard tissues supporting a restoration (i.e. dentin and enamel) to be exposed to acidic conditions beyond that resulting from dietary variations. In this investigation the fatigue strength and fatigue crack growth resistance of human coronal dentin were characterized within a lactic acid solution (with pH = 5) and compared to that of controls evaluated in neutral conditions (pH = 7). A comparison of the fatigue life distributions showed that the lactic acid exposure resulted in a significant reduction in the fatigue strength (p ≤ 0.001), and nearly 30% reduction in the apparent endurance limit (from 44 MPa to 32 MPa). The reduction in pH also caused a significant decrease (p ≤ 0.05) in the threshold stress intensity range required for the initiation of cyclic crack growth, and significant increase in the incremental rate of crack extension. Exposure of tooth structure to lactic acid may cause demineralization, but it also increases the likelihood of restored tooth failures via fatigue, and after short time periods.


Assuntos
Dentina/química , Ácido Láctico/efeitos adversos , Desmineralização do Dente/induzido quimicamente , Adolescente , Adulto , Esmalte Dentário/química , Humanos , Concentração de Íons de Hidrogênio , Microscopia Eletrônica de Varredura , Estresse Mecânico , Propriedades de Superfície , Desmineralização do Dente/patologia , Adulto Jovem
4.
Actual. enferm ; 2(1): 19-23, mar. 1999.
Artigo em Espanhol | LILACS | ID: lil-338220

RESUMO

Este artículo hace parte de la investigación "Impacto de la reforma del sector salud en la práctica, la regulación y la educación de enfermería en Colombia". El propósito es dar a conocer a los profesionales de enfermería, a los administradores del sector salud y al público en general, los ámbitos y mecanismos de regulación de la profesión de enfermería en el país. En la discusión se plantean observaciones tanto a los sectores aún desprotegidos de dicha regulación, como a las áreas que ameritan un replanteamiento. Finalmente se destacan algunos de los mecanismos informales de reglamentación que la sociedad va estableciendo


Assuntos
Colômbia , Enfermagem/organização & administração , Enfermagem , Enfermagem/tendências
5.
Rev. chil. infectol ; 16(2): 137-46, 1999. tab, graf
Artigo em Espanhol | LILACS | ID: lil-257965

RESUMO

La hidatidosis es un importante problema de salud pública que se encuentra subestimado por la dificultad de su vigilancia epidemiológica. Para estimar la magnitud de la subnotificación de esta patología, se analizaron los egresos hospitalarios en comparación con las notificaciones realizadas en el formulario RMC 14 (Registro Mensual Consolidado de Enfermedades de Notificación Obligatoria), entre los años 1993 y 1997 en la provincia de Ñuble. Se observó que el porcentaje de subnotificación alcanzó un 73 por ciento. Las tasas de morbilidad y mortalidad por esta enfermedad son mayores en la provincia de Ñuble, con relación al país, con una tendencia estable en el tiempo. Esta patología presenta su sintomatología preferentemente en edades productivas, con largas estadías hospitalarias, con intervenciones quirúrgicas importantes y licencias laborales prolongadas; además de la repercusión sobre la producción animal, lo cual hace necesario realizar programas preventivos focalizados en los lugares de mayor riesgo


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Adolescente , Adulto , Pessoa de Meia-Idade , Equinococose/epidemiologia , Notificação de Doenças/estatística & dados numéricos , Alta do Paciente/estatística & dados numéricos , Distribuição por Idade , Estudos de Casos e Controles , Chile/epidemiologia , Custos de Cuidados de Saúde/estatística & dados numéricos , Equinococose/economia , Equinococose/cirurgia , Hospitais Estaduais/estatística & dados numéricos , Distribuição por Sexo , Saneamento de Matadouros
6.
Rev. chil. infectol ; 14(2): 110-8, 1997. tab
Artigo em Espanhol | LILACS | ID: lil-211986

RESUMO

Se describe un brote epidémico de sarampión ocurrido en la comuna de Pinto, provincia de Ñuble, VIll Región, ubicada a 24 km. al suroriente de Chillán, que afectó a veinte personas, de los cuales dieciocho fueron investigadas por este Servicio de Salud. Por antecedentes obtenidos en la visita epidemiológica al Centro Invernal Termas de Chillán, se identificó a un turista brasileño como caso primario que presentó un cuadro febril exantemático, el cual estuvo hospedado en un hotel del complejo turístico entre la segunda y tercera semana de Julio de 1997. Pos.teriormente se presentó la enfermedad en diez personas que trabajaban en el Centro Invernal, ocho de las cuales residían en la comuna de Pinto, una residía en Concepción, y la-otra en Chillán. Los trabajadores del Complejo afectados por esta enfermedad la contagiaron a ocho residentes de la comuna de Pinto, entre ellos tres menores de un año. Uno de los dieciocho pacientes investigados correspondía a un familiar del trabajador residente en Chillán. De los veinte casos detectados quince eran hombres; los rangos de las edades fluctuaban entre 3 meses y 36 años, con un promedio de edad de 21 años. Ninguno presentó complicaciones ni hubo fallecidos. Se realizó vacunación a las personas del grupo etario susceptible (20 a 40 años) en algqna de las siguientes condiciones: Personal del complejo turístico donde se presentó el brote; Personal de salud y de salas-cuna de la provincia de Ñuble; Habitante de la comuna de Pinto (la cual posee un 60 por ciento de ruralidad)


Assuntos
Humanos , Masculino , Feminino , Sarampo/epidemiologia , Surtos de Doenças/estatística & dados numéricos , Vacina contra Sarampo/administração & dosagem
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