Severe Raynaud syndrome induced by adjuvant interferon alfa in metastatic melanoma.

Melanoma is the most lethal form of skin malignancy because of its aggressive behaviour. In advanced disease, interferon alfa can be used as adjuvant therapy. However, this therapy is not free of side effects. We present a case of severe Raynaud syndrome and digital necrosis induced by interferon alfa in a patient with melanoma. Pathogenic mechanisms are discussed.

Nevus azul con área central despigmentada / Blue naevus with central depigmented area

El nevus azul es una lesión benigna papular o nodular con coloración que varía desde el azul-oscuro al azulnegruzco. Las localizaciones más comunes son el dorso de las manos y pies, brazos, piernas, cara y cuero cabelludo. Se presenta el caso de una mujer de 60 años con una lesión sobreelevada en el cuero cabelludo de más de 30 años de evolución, en cuyo centro apareció un área central despigmentada. Tras la toma de biopsia y posterior extirpación completa de la lesión, fue diagnosticada de nevus azul celular. La aparición de dicha área central despigmentada posiblemente está relacionada con un traumatismo continuado y repetitivo por la acción del cepillado del pelo. (AU)

[Skin aging and smoking]. / Envejecimiento cutáneo y tabaquismo.

Facial wrinkling is a marker of skin ageing. The association between smoking and facial wrinkling has been previously studied. Nevertheless, there are no reports assessing the role of sun exposure and smoking in an area with a great proportion of sunny days. Smoking habits were investigated in 282 healthy individuals. Facial wrinkles were measured according to the Daniell scale at the external canthus. A logistic regression model was developed controlling for age, sex, sun exposure, smoking habit and searching for the interaction between sun exposure and smoking. A statistically significant risk was found for smoking habit (OR = 3.1; 95% CL 1.28-7.76; p = 0.008), sun exposure (OR = 1.50; 95% Cl 1.25-1.80; p = 0.05), and age (OR = 1.18; 95% Cl 1.13-1.23; p = 0.024) for facial wrinkling. These results show the evidence of an accelerated skin ageing in smokers. A clear explanation given to smokers could be a useful strategy to persuade them to leave smoking.

[Melanoma-lymphoma association]. / Associazione melanoma-linfoma.

The association of malignant melanoma with different neoplasias is uncommon but not exceptional. We present two cases of malignant melanoma associated with lymphoma, and analyze the variety of etiopathogenic factors which have been implicated in both neoplasias, with special emphasis on those that may explain this association.

[Dermatosis with the phenomenon of transepidermal elimination]. / Dermatosis con fenómeno de eliminación transepidérmica.

A revision was carried out on all cases of dermatosis involving transepidermal elimination seen in the last 25 years in the Department of Medical Surgical Dermatology and Venereology, School of Medicine, University of Granada. The study included clinical-statistical, therapeutic, histopathologic and evolutional aspects. In the discussion the low incidence of perforating dermatoses in the Eastern Andalusian area is emphasized.

[23 observations of subungual exostosis]. / Veintitrés observaciones de exostosis subungueal.

Twenty-three cases of subungual exostosis are described, representing an incidence of 0.031% in our setting. Children and adolescents were most frequently affected, with a clear predominance of females. Eight lesions were observed in exceptional locations, three on the fingers and five on the third and fourth toes. The results of the surgical technique employed to excise the exostosis are evaluated.

[Infantile acro-localized papulo-vesicular syndromes]. / Síndromes pápulo-vesiculosos acrolocalizados infantiles.

Seven observations of papulo-vesicular acrolocated syndromes in males between 6 months and three years age. Clinical, histological and nosological aspects are commented in according to Gianotti's words and last reports about this disease.