Implementation of a Student Success Seminar and its Correlation with Resilience in Nursing Students: A Mixed-Methods Study.

AIM: To identify sustainable curricular practices that promote student resilience. METHOD: Sophomore students in a four-year baccalaureate nursing program attended a positive psychology seminar and a formal mentoring program led by senior- and junior-level nursing students. Sophomore students 'resilience was measured pre- and post-intervention using the Predictive 6-Factor Resilience Scale (PR6). Additional rich descriptions from the experience of the mentoring program were obtained in surveys from the study participants and mentors at the completion of the program. FINDINGS: Quantitative and qualitative results supported a strong increase in resilience. CONCLUSION AND IMPLICATIONS FOR PRACTICE: Nursing schools can provide students with sustainable support that promotes resilience.

Endoplasmic reticulum stress and ubiquitin-proteasome system impairment in natural scrapie.

Chronic accumulation of misfolded proteins such as PrPSc can alter the endoplasmic reticulum homeostasis triggering the unfolded protein response (UPR). In this pathogenic event, the molecular chaperones play an important role. Several reports in humans and animals have suggested that neurodegeneration is related to endoplasmic reticulum stress in diseases caused by the accumulation of misfolded proteins. In this study, we investigated the expression of three endoplasmic reticulum stress markers: PERK (protein kinase R-like endoplasmic reticulum kinase), BiP (binding immunoglobulin protein), and PDI (Protein Disulfide Isomerase). In addition, we evaluated the accumulation of ubiquitin as a marker for protein degradation mediated by the proteasome. These proteins were studied in brain tissues of sheep affected by scrapie in clinical and preclinical stages of the disease. Results were compared with those observed in healthy controls. Scrapie-infected sheep showed significant higher levels of PERK, BiP/Grp78 and PDI than healthy animals. As we observed before in models of spontaneous prion disease, PDI was the most altered ER stress marker between scrapie-infected and healthy sheep. Significantly increased intraneuronal and neuropil ubiquitinated deposits were observed in certain brain areas in scrapie-affected animals compared to controls. Our results suggest that the neuropathological and neuroinflammatory phenomena that develop in prion diseases cause endoplasmic reticulum stress in brain cells triggering the UPR. In addition, the significantly higher accumulation of ubiquitin aggregates in scrapie-affected animals suggests an impairment of the ubiquitin-proteasome system in natural scrapie. Therefore, these proteins may contribute as biomarkers and/or therapeutic targets for prion diseases.

Relación de apeoo en madres adolescentes y sus bebés canguro / Attchment relatiionships between adolescent mothers and their 'kangaroo'bbabies

The effect of mothers’ age and the participation in the Kangaroo Mother Care (KMC) on attachment relationships, was studied in a group of mothers and their infants from low socioeconomic status sample. The mother–infant interaction was observed in daily situations, finding out that the KMC increases the mother’s sensitivity and decreases the negative effects of poverty, prematurity, hospitalisation and teenage maternity on infant security. The KMC does not increase the possibility that the infants establish insecure attachment relationships. These findings provide necessary evidence for the development of prevention-intervention programs for high risk populations.

Este estudio investigó el efecto de la edad materna y la participación en el Programa Madre Canguro (PMC) sobre el la relación de apego establecida en un grupo de madres y bebés de estrato socioeconómico bajo. Las díadas se agruparon dependiendo de, a) la edad de las madres al momento del parto (madres adolescentes y madres adultas); y b) la participación de los bebés en el PMC (bebés canguro y bebés no-canguro). La evaluación de las interacciones madre-bebé se llevó a cabo a través de observaciones naturalistas en las casas de las familias. Los resultados indicaron que el programa de atención alternativo para los bebés de bajo peso al nacer, el PMC, incrementa la sensibilidad materna y disminuye el efecto negativo de variables como la pobreza, la prematurez, la hospitalización y separación temprana, y la maternidad adolescente sobre la primera relación de apego. Se encontró además que el PMC no incrementa la posibilidad de establecer relaciones de apego inseguras entre los bebés y sus madres; al contrario, la participación en el PMC se constituyó como un factor de protección para éstas díadas. Los resultados proveen insumos útiles para el desarrollo de programas de prevención-intervención dirigidos a poblaciones de alto riesgo, a la vez que contribuyen al fortalecimiento de conceptos, áreas de análisis y metodologías propias de la teoría del apego en el contexto colombiano.