SLPI in the perfusion solution helps to identify graft quality in kidney transplants.

Aim: It is important to find biomarkers that identify the graft quality in kidney transplantation. Results & methodology: The level of SLPI in the cold preservation solution was used as a marker to predict early kidney graft function after transplantation. Before transplantation, kidneys were washed and SLPI was measured in the discarded solution. A retrospective analysis showed that patients with delayed graft function or rejection episodes in post-trasplant, had higher SLPI concentrations in the perfusion solution than patients without delayed graft function or rejections. Furthermore, SLPI could discriminate between patients with better or worse estimated glomerular filtration rate among low-risk patients (kidney donor profile index <80). Discussion & conclusion: These results suggest that the SLPI concentration in the perfusion solutions could be a predictor of short-term organ function and a complement to the kidney donor profile index score.

Trasplante simultáneo de riñón y páncreas exitoso en paciente con lipodistrofia parcial congénita / Successfull Simultaneous Pancreas Kidney transplantation in a patient with congenital partial lipodystrophy

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[Digestive tract cancer: after ten years in Santa Fe]. / Cancer de tubo digestivo: diez años después en Santa Fe.

In our earlier paper we found that esophageal cancer was the most frequent localization among all the digestive tract cancers. Furthermore, in four departments belonging to our province we also observed a colon-esophagus relationship of virtually 1 to 1. In this study we aimed to: 1) estimate the prevalence of esophagus and stomach tumors: a) in the Endoscopy Department, b) in all the hospital, comparing it with colon cancer and, c) as causes of death in our region of influence, in relation to all the neoplastic pathologies. 2) analyze the histological lineage and the anatomical location, according to sex, age and origin. We evaluated: 3,396 upper digestive tract endoscopies, the diagnoses of digestive tract cancer from the Histopathology Service, the discharges from hospital as the result of digestive tract cancer from the General Archives, all of them from Cullen Hospital, and death register of the province of Santa Fe accounting for digestive tract cancer. A descriptive analysis was carried out and spreadsheet from the Open Office 2.2 version and SPSS 10.0 version were used. We observed that esophageal cancer is still very frequent in the Endoscopy Department and in the Histopathology Service but not in the diagnoses at discharge from hospital. It shares similar epidemiological features to the ones observed in the international literature. The reduction of the relationship between colon and esophageal cancer in the global mortality rate of the country turns out to be surprising. In three departments situated on the north of the province it was observed a colon-esophagus cancer relationship of 1:1.