[Biochemical mechanisms of realization of antiviral and interferon-inducing activity of amixine and its analogs]. / Biokhimicheskie mekhanizmy realizatsii protivovirusnoi i interferonindutsiruiushchei aktivnosti amiksina i ego analogov.

Antiviral and interferon inducing activity of the amixine and its some derivatives, as well as their influence on the proteolytic enzymes activity, monooxygenase activity of the microsomal fraction, level of the lipids peroxidation were studied. Lack of correlation between antiviral and interferon inducing activity in the investigated series of compounds was found. Vice versa, the good correlation between interferon inducing activity and the elastase-like activities inhibition ability of the compounds was observed. It allows to state the assumption, that only one ability of compounds to induce of an interferon doesn't suffice for obtaining of high titres of interferon, and while their rather high antiproteolitic activity is necessary. It's shown, that except for one compound the influence of amixine and its derivatives on the red-ox enzymes activity well correlates with their ability to the interferon-inducing. All presented above allows to attribute amixine and its derivatives to polymodal antiviral agents.

[Effect of enomelanin on lipid peroxidation and the glutathione system in rat lung tissue exposed to NO2]. / Vliianie 'enomelanina na perekisnoe okislenie lipidov i sistemu glutationa v legochnoi tkani krys pri deistvii NO2.

Effect of preliminary intraperitoneal injection on the state of the glutathione system and lipid peroxidation intensity in the lungs of rats subjected to NO2 has been studient. This compound is shown to decrease significantly all lipid peroxidation processes and to inhibit completely glutathion oxidation. These effects are supposed to be a result not only of antioxidant properties of enomelanin, but also of its ability to promote a decrease in the activity of glutathione-depending enzymes subjected to NO2.

[Biochemical mechanisms of protective action of enomelanin during hemic hypoxia caused by carbon monoxide]. / Biokhimicheskie mekhanizmy zashchitnogo deistviia énomelanina pri gemicheskoi gipoksii, vyzvannoi ugarnym gazom.

Prophylactic injection of enomelanine has been studied for its effect on hemic hypoxia and on different parts of breathing system. The enomelanine was shown to be effective for decreasing the level of carboxyhemoglobin and for protection from succinate dehydrogenase and cytochromoxidase. The authors think that these effects of enomelanine are conditioned not only by its anti-hypoxia abilities, but also by the capacity to activate the alternative protective mechanisms of the cell.