1.
Org Lett
; 17(1): 154-7, 2015 Jan 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25522825
RESUMO
The asymmetric total synthesis of (-)-leuconoxine has been achieved. The desymmetrization of a prochiral diester using a chiral phosphoric acid catalyst produced a highly enantioenriched lactam with excellent yield. The ring construction featuring an intramolecular N-acyliminium cyclization and the one-step pyrrolidone formation using Bestmann's ylide was successfully accomplished.