RESUMO
Comparative evaluation of clinical, neurophysiologic and laboratory data changes in 154 workers exposed to vibration in mining industry helped to identify the most informative criteria of vibration disease diagnosis. Scientifically justified use of neurospecific parameters - S100B protein and neurospecific enolase - was aimed to evaluate vibration disease severity.
Assuntos
Mineração , Doenças Profissionais , Fosfopiruvato Hidratase/análise , Polineuropatias , Subunidade beta da Proteína Ligante de Cálcio S100/análise , Vibração/efeitos adversos , Biomarcadores/análise , Humanos , Masculino , Pessoa de Meia-Idade , Neurofisiologia/métodos , Doenças Profissionais/diagnóstico , Doenças Profissionais/etiologia , Doenças Profissionais/metabolismo , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/análise , Polineuropatias/diagnóstico , Polineuropatias/etiologia , Polineuropatias/metabolismo , Índice de Gravidade de DoençaRESUMO
The authors revealed influence of occupational vibration on development of resistance to insulin and of II type diabetes mellitus in miners. With that, increased serum insulin level was diagnosed in the workers. Occurrence of patients with. increased insulin level reaches 70% in vibration disease. The most intensively changed indexes are CARO and HOMA-IR, that identify early latent changes in resistance to insulin. Vibration appeared to influence significantly on II type diabetes mellitus development. Prevalence of II type diabetes mellitus among vibration disease patients is 5 times higher than that in general population of Russian Federation.
Assuntos
Diabetes Mellitus Tipo 2 , Resistência à Insulina , Insulina/análise , Obesidade , Doenças Profissionais , Vibração/efeitos adversos , Índice de Massa Corporal , Diabetes Mellitus Tipo 2/diagnóstico , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/prevenção & controle , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/diagnóstico , Obesidade/epidemiologia , Doenças Profissionais/diagnóstico , Doenças Profissionais/epidemiologia , Doenças Profissionais/prevenção & controle , Saúde Ocupacional , Prevalência , Fatores de Risco , Federação Russa/epidemiologiaRESUMO
The diagnostic significance of hormones and integral indices of pituitary-adrenal, pituitary-thyroid and pituitary-gonadal system and carbohydrate metabolism (ACTH (corticotropin), aldosterone, cortisol, TSH (thyroid-stimulating hormone), free triiodothyronine (fT3), free thyroxine (fT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total and free testosterone, insulin, integral pituitary-adrenal index (IPAI), the pituitary-thyroid index (PTI), indices of carbohydrate metabolism (Caro and HOMA-IR) was studied for the early diagnostics of disorders of neurohumoral regulation in workers of mining and mechanical engineering industries. The most informative indices, permitting to identify disorders of carbohydrate metabolism are established to be indices of insulin resistance (index Caro and index NOMA-IR) and the determination of insulin in serum. For the identification of changes in pituitary adrenal, pituitary-thyroid and pituitary-gonadal system in patients with vibration disease, sensory-neural hearing loss, comorbidity indexes IGNI, ITI, concentrations of LH and total testosterone are of the most diagnostically significance.
Assuntos
Hormônio Adrenocorticotrópico/sangue , Hormônio Foliculoestimulante/sangue , Insulina/sangue , Doenças Profissionais , Tireotropina/sangue , Adulto , Biomarcadores/sangue , Metabolismo dos Carboidratos/fisiologia , Indústrias Extrativas e de Processamento/métodos , Indústrias Extrativas e de Processamento/normas , Feminino , Humanos , Sistema Hipotálamo-Hipofisário/metabolismo , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/sangue , Doenças Profissionais/diagnóstico , Doenças Profissionais/etiologia , Doenças Profissionais/prevenção & controle , Saúde Ocupacional , Sistema Hipófise-Suprarrenal/metabolismo , Reprodutibilidade dos TestesRESUMO
The authors studied influence of vibration on serum neurotropic protein S100B level in miners. Vibration appeared to cause significant effect on increase of this protein level. With that, there is a moderate correlation between the protein level and intensity of the vibration effect.
